公开(公告)号：US10967294B1

公开(公告)日：2021-04-06

申请号：US16893309

申请日：2020-06-04

申请人： ThermoLife International, LLC

发明人： Ronald Kramer ,  Alexandros Nikolaidis

IPC分类号： B01D11/02 ,  A61K36/21 ,  A61K36/18 ,  A23L5/30 ,  A61K36/185 ,  A23L5/20

摘要： The present disclosure relates to methods of enriching beetroot products to increase the nitrate content of the beetroot powder product. The disclosure also relates to beetroot powder products with increased with at least 4% nitrate.

公开(公告)号：US20200246249A1

公开(公告)日：2020-08-06

申请号：US16854160

申请日：2020-04-21

申请人： MARY KAY INC.

发明人： Tiffany Florence ,  Michelle Hines

IPC分类号： A61K8/97 ,  A61K36/18 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08 ,  A61K8/06 ,  A61K8/04

摘要： A method of treating a skin condition resulting from exposure to pollution or free radicals is disclosed. The method can include topically applying to skin having the skin condition a composition comprising an effective amount of an extract of Diospyros mespiliformis leaf to reduce oxidative damage in the skin having the skin condition.

公开(公告)号：US10702544B2

公开(公告)日：2020-07-07

申请号：US16069496

申请日：2017-01-11

申请人： National University Corporation Tokyo Medical and Dental University

发明人： Emi Nishimura ,  Hiroyuki Matsumura

IPC分类号： A61K31/713 ,  A61K38/55 ,  A61K36/05 ,  A61K36/14 ,  A61K36/47 ,  A61K36/48 ,  A61K36/54 ,  A61K8/97 ,  A61K31/506 ,  A61K36/489 ,  A61K36/738 ,  A61K36/04 ,  A61K36/424 ,  A61Q5/00 ,  A61K48/00 ,  A61K31/7088 ,  C12Q1/37 ,  A61K36/30 ,  A61K36/74 ,  A61K36/23 ,  A61K36/60 ,  A61K36/185 ,  A61Q7/00 ,  A61K36/718 ,  A61K36/488 ,  A61K36/53 ,  A61K36/82 ,  A61K39/395 ,  A61K36/18 ,  A61K36/28 ,  A61K31/222 ,  A61K45/00 ,  A61P17/14 ,  A61K31/05 ,  A61K31/16 ,  A61K31/355 ,  A61K31/375 ,  A61K31/381 ,  A61K31/7048 ,  A61K31/13 ,  A61K36/00

摘要： The present invention provides novel compositions for suppressing or improving hair loss, and compositions for suppressing or improving graying. More specifically, it provides agents that stabilize type XVII collagen expression, preferably agents that suppress the degradation of type XVII collagen by ELANE inhibitors and such, and compositions comprising a DNA repair-promoting agent or a DNA damage-suppressing agent as an active ingredient. Advantageous suppressive effects of hair loss and graying can be obtained when a composition comprising as an active ingredient a suppressive agent of type XVII collagen degradation such as an ELANE inhibitor is administered to a mammal. For the ELANE inhibitors, suppressive agents of type XVII collagen degradation and DNA repair-promoting agents, low-molecular compounds, polypeptides, proteins, antibodies, or nucleic acid medicine such as antisense oligos or siRNAs may be used. A method of screening for effective substances for suppression of hair loss and graying is also provided.

公开(公告)号：US10660845B2

公开(公告)日：2020-05-26

申请号：US15987607

申请日：2018-05-23

申请人： MARY KAY INC.

发明人： Tiffany Florence ,  Michelle Hines

IPC分类号： A61K8/97 ,  A61K36/18 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08 ,  A61K8/06 ,  A61K8/04

摘要： A method of treating a fine line or wrinkle on a person's skin or increasing collagen production in skin is disclosed. The method can include topically applying to the skin a composition comprising an effective amount of an aqueous, alcoholic, or aqueous-alcoholic extract of Diospyros mespiliformis leaf to treat the fine line or wrinkle or to increase collagen production in the skin.

公开(公告)号：US10568847B2

公开(公告)日：2020-02-25

申请号：US15434226

申请日：2017-02-16

申请人： James J. Caprio

发明人： James J. Caprio

IPC分类号： A61K36/18 ,  A61K31/05 ,  A61K31/352 ,  A61K36/185 ,  A61K45/06

摘要： The subject invention pertains to methods and compositions for the treatment of erectile dysfunction (ED) (e.g., impotence) in a subject in need thereof utilizing one or more cannabinoid and one or more anti-ED drug.

公开(公告)号：US20200000798A1

公开(公告)日：2020-01-02

申请号：US16434494

申请日：2019-06-07

申请人： UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL-UFRGS ,  HOSPITAL DE CLÍNICAS DE PORTO ALEGRE (HCPA)

发明人： Patricia GNIESLAW DE OLIVEIRA ,  Graziele PEREIRA RAMOS PEDRAZZA ,  Mirian FARINON ,  Xavier RICARDO MACHADO ,  José Angelo SILVEIRA ZUANAZZI ,  Fernanda SPIES

IPC分类号： A61K31/4748 ,  A61P19/02 ,  A61P19/10 ,  A61K36/18 ,  A61P37/06

摘要： The present invention describes a method for completely extracting the alkaloid fraction (montanine) of Rhodophiala bifida (Herb.) Traub from bulbs of Rhodophiala bifida. The present invention further describes a method for treating inflammation using pharmaceutical compositions containing the alkaloid fraction of Rhodophiala bifida as the active ingredient. The present invention therefore comprises an extraction method that is faster than other extraction methods described in the literature for the alkaloid fraction of Rhodophiala bifida, dispensing with numerous changes of solvent in order to strain the plant, and the use thereof as an anti-inflammatory. The present invention is further characterised by the development of an anti-inflammatory medicinal drug for treating and preventing diseases involving inflammation and/or the local increase in the number of fibroblasts as its etiopathogenesis, such as: rheumatoid arthritis, ulcerative colitis, sepsis, acute pulmonary disease, inflammatory infections, in particular inflammatory and fibrosing diseases related to the lungs and kidneys, osteoporosis, Castleman disease, psoriatic arthritis, juvenile chronic arthritis and other non-specific inflammatory joint diseases.

公开(公告)号：US10441618B2

公开(公告)日：2019-10-15

申请号：US15770620

申请日：2016-10-21

申请人： Kazuhiko Sugiura ,  Aditya Kulkarni

发明人： Kazuhiko Sugiura ,  Aditya Kulkarni

IPC分类号： A61K36/18 ,  A61K36/185 ,  A23L2/52 ,  A23G3/34 ,  A23G4/00 ,  A23L33/105 ,  A23L9/10 ,  A23F5/46 ,  A23G3/48 ,  A23G4/06 ,  A23G9/42 ,  A23L2/54 ,  A61K31/7034 ,  A23G1/48 ,  A23G3/36 ,  A23L2/39

摘要： A moringa extract containing a benzyl glucosinolate in a content of 6% by mass or more, calculated as a dry solid content of the extract, wherein the extract does not substantially contain an alkaloid. The moringa extract of the present invention for solving a first aspect is useful in the field of foodstuff or the like. Also, the PPAR activator of the present invention for solving a second aspect has excellent PPAR activation action, and has no disadvantages in side effects, so that it can be ingested for long term, which can be preferably used in foodstuff and the like. Therefore, the PPAR activator of the present invention for solving a second aspect can be expected to be used as a food, a supplement or a medicament not only for prevention of disease such as insulin resistance, hyperinsulinism, Type 2 diabetes, hypertension, hyperlipidemia, arterial sclerosis and obesity, but also for fatigue recovery or endurance improvement by improving basal metabolism. In addition, a benzyl glucosinolate-containing composition for solving a third aspect is useful in the field of foodstuff or the like.

公开(公告)号：US20180344785A1

公开(公告)日：2018-12-06

申请号：US15095174

申请日：2016-04-11

申请人： Bradley Lee Robertson

发明人： Bradley Lee Robertson

IPC分类号： A61K36/18 ,  A61K31/352

摘要： A method for the extraction and isolation of the terpene and isoprenoid compounds from plant material, followed by a centrifugal force induced selective crystallization of isoprenoids resulting in a separation of terpene and isoprenoid fractions. This this method is suitable for the extraction of cannabinoids from Cannabis and the enrichment tetrahydrocannabinolic acid and reduction of tetrahydrocannabinol in an extract.

公开(公告)号：US20180193250A1

公开(公告)日：2018-07-12

申请号：US15816175

申请日：2017-11-17

申请人： Mary Kay Inc.

发明人： Jim Faller ,  David Gan ,  Michelle Hines ,  Lisa Mangos

IPC分类号： A61K8/97 ,  A61Q19/08 ,  A61K8/04 ,  A61Q19/00 ,  A61K8/06 ,  A61K8/34 ,  A61K36/752 ,  A61K36/18 ,  A61K8/73 ,  A61K8/67 ,  A61K8/64 ,  A61K8/55 ,  A61K8/49 ,  A61K8/35

CPC分类号： A61K8/97 ,  A61K8/042 ,  A61K8/06 ,  A61K8/062 ,  A61K8/347 ,  A61K8/35 ,  A61K8/498 ,  A61K8/553 ,  A61K8/64 ,  A61K8/678 ,  A61K8/73 ,  A61K36/18 ,  A61K36/752 ,  A61K2800/10 ,  A61K2800/522 ,  A61K2800/591 ,  A61K2800/782 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/007 ,  A61Q19/008 ,  A61Q19/08

摘要： Disclosed is a composition and method for its use that includes Magnolia bark extract, vitis vinifera extract, tocopherol or tocopherol acetate, and hydrogenated lecithin, lecithin, or dextrin.

公开(公告)号：US09937239B2

公开(公告)日：2018-04-10

申请号：US14697797

申请日：2015-04-28

申请人： The Johns Hopkins University

发明人： David K. Karig

IPC分类号： A61K38/00 ,  A61K38/45 ,  A61K35/74 ,  A61K36/18 ,  A61K36/06 ,  A61K35/12 ,  C09K3/00 ,  A61K36/899 ,  A61K36/064 ,  A61K35/63

CPC分类号： A61K38/45 ,  A61K35/12 ,  A61K35/63 ,  A61K35/74 ,  A61K36/06 ,  A61K36/064 ,  A61K36/18 ,  A61K36/899 ,  C09K3/00 ,  C12Y207/03002 ,  Y02A50/473 ,  A61K2300/00

摘要： A method of preserving a cell-free protein expression system includes preserving a cell extract with a first non-reducing sugar alcohol to provide a preserved cell extract, preserving a reaction buffer with a second non-reducing sugar alcohol to provide a preserved reaction buffer, and preserving an energy source, so that the cell extract, the reaction buffer, and the energy source are preserved separately.