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11.发明授权公开(公告)号：US10479979B2
公开(公告)日：2019-11-19
申请号：US15392620
申请日：2016-12-28
发明人： Michael Keidar , Jerome Canady , Dayun Yan
摘要： A method for preparing cold atmospheric plasma stimulated cell culture media with a cold atmospheric plasma system having a delivery port out of which an inert gas flows. The inert gas may be helium. The method comprises the steps of placing a cell culture media in a first well, the first well having a bottom and having a diameter greater than 20 mm; wherein the cell culture media placed in the first well has a volume of 4 ml or less, treating the cell culture media in the first well with cold atmospheric plasma, wherein the treating is performed with a gap between the delivery port and the bottom of the first well is between 2.5 cm and 3.5 cm, and transferring a portion of the treated media to cultured cancer cells in a second well. The cold atmospheric plasma may be applied for 0.5 minutes to 2 minutes.
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12.发明申请公开(公告)号：US20190279849A1
公开(公告)日：2019-09-12
申请号：US16298484
申请日：2019-03-11
发明人： Jerome Canady , Michael Keidar , Zhitong Chen
摘要： A method for manufacturing plasma-activated saline for treatment of cancer cells. The method comprises the steps of immersing a cathode in saline solution in a container, positioning an anode at a fixed distance from a surface of said saline solution in said container and applying electrical energy to said anode for a fixed period of time, wherein said fixed distance and said fixed period of time are selected to cause a plasma self-organized pattern at a surface of said saline solution with an atmospheric discharge between said anode and said cathode.
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公开(公告)号：USD856514S1
公开(公告)日：2019-08-13
申请号：US29628684
申请日：2017-12-06
设计人： Jerome Canady , Feng Yan , Taisen Zhuang
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公开(公告)号：US20160235462A1
公开(公告)日：2016-08-18
申请号：US15042180
申请日：2016-02-12
发明人： Jerome Canady , Taisen Zhuang
CPC分类号： A61B18/042 , A61B2018/0063 , A61B2018/1462
摘要： In a preferred embodiment, the present invention is a plasma sealer attachment for an electrosurgical system. The attachment has a connector assembly, a cable, and a hand piece. The hand piece has a splitter, a pair of tubes and a pair of conductive wires. When used, an inert gas flows through the connector assembly, down the cable and out both tubes. One of the conductive wires is connected to a source of monopolar electrosurgical energy and acts as an active electrode. The other conductive wire is connected to a neutral or ground and acts as a return electrode.
摘要翻译： 在优选实施例中，本发明是用于电外科系统的血浆封闭器附件。 附件具有连接器组件，电缆和手持件。 手持件具有分流器，一对管和一对导电线。 当使用时，惰性气体通过连接器组件，沿着电缆流出并且两个管流出。 其中一条导线连接到单极电外科手术能源，并充当有效电极。 另一条导线连接到中性线或地线，并作为返回电极。
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公开(公告)号：US11253310B2
公开(公告)日：2022-02-22
申请号：US16604412
申请日：2018-04-10
发明人： Jerome Canady , Taisen Zhuang , Shruti Wigh , Daniel Tabatabai
摘要： A gas-enhanced electrosurgical generator. The gas-enhanced generator has a housing, a first gas control module in the housing and configured to control flow of a first gas, a second gas control module in the housing and configured to control flow of a second gas, a high frequency power module, and a controller, processor or CPU within the housing and configured to control the first gas control module, the second gas control module and the high frequency power module. The first gas and second gas may be any of CO2, argon and helium or another gas. The gas-enhanced electrosurgical generator may have a third gas control module in the housing and configured to control flow of a third gas and a third connector secured on an exterior of the housing.
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公开(公告)号：US10973564B2
公开(公告)日：2021-04-13
申请号：US15991609
申请日：2018-05-29
发明人： Jerome Canady , Alexey Shashurin , Michael Keidar , Taisen Zhuang
摘要： An integrated gas-enhanced electrosurgical generator. The generator comprises a high frequency power module, a low frequency power module and a gas module. The high frequency power module adapted to generate an electrical energy having a band of frequencies centered around a first frequency, wherein the electrical energy has a first power as the first frequency and a second power lower than the first power at a second frequency lower than the first frequency. The low frequency power module having an input connected to an output of the high frequency module. The low frequency module comprises a resonant transformer comprising a ferrite core, a primary coil and a secondary coil, the secondary coil having a larger number of turns than the primary coil, wherein the resonant transformer has a resonant frequency equal to the second frequency. The gas module is adapted to control a flow of an inert gas.
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公开(公告)号：USD884190S1
公开(公告)日：2020-05-12
申请号：US29583504
申请日：2016-11-06
设计人： Jerome Canady , Dereck Chiu , Feng Yan , Taisen Zhuang , Tse Huai Wu
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公开(公告)号：US10405913B2
公开(公告)日：2019-09-10
申请号：US14876358
申请日：2015-10-06
发明人： Jerome Canady , Taisen Zhuang
摘要： An attachment for an electrosurgical hand piece. The attachment comprises a probe assembly having an elongated tube having a proximal end and a distal end, and an electrode. The electrode has at a proximal end a conductive connector, which has a proximal end, a distal end and a channel extending through the conductive connector. The conductive connector may be comprised of a nickel plated brass alloy. The electrode further has a conductive wire extending from said distal end of said conductive connector, said conductive wire being connected to said distal end of said conductive connector adjacent to said channel in said conductive connector. The conductive wire extends substantially along the length of the elongated tube and may or may not extend out of the end of the tube.
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19.发明申请公开(公告)号：US20190231411A1
公开(公告)日：2019-08-01
申请号：US16259923
申请日：2019-01-28
发明人： Jerome Canady , Michael Keidar
CPC分类号： A61B18/042 , A61B2018/00648 , A61B2018/00684 , A61B2018/0069 , A61B2018/00696 , A61B2018/00988 , A61N1/44 , C12N5/0093 , G16H20/40 , G16H40/60
摘要： A method for applying cold atmospheric plasma treatment to target tissue comprising the steps of selecting through a graphical user interface on a computing device a particular cancer cell line associated with said target tissue, retrieving, with said computing device, settings data from a database of cell line data and associated settings data in a storage, applying, with said computing device, said retrieved settings data to a cold atmospheric plasma system, and treating cancer tissue with cold atmospheric plasma at the retrieved settings.
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公开(公告)号：US10329535B2
公开(公告)日：2019-06-25
申请号：US15392596
申请日：2016-12-28
发明人： Barry Trink , Michael Keidar , Jerome Canady
摘要： A method for treating cancer stem cells with cold atmospheric plasma using a cold atmospheric plasma system The method comprises the steps of placing an exit port of a cold plasma delivery device 5 cm or less from target cancer stem cells, flowing the inert gas from the source through the housing at a flow rate of 5-10 ml/minute, applying electrosurgical energy of 2-5 kV at a frequency of 20-35 kHz to at least one of the central electrode and the ring electrode to produce a cold plasma jet from the exit port, directing the cold plasma jet onto the target cancer stem cells, and applying the cold plasma jet onto the target cancer stem cells for at least 2 minutes. In a preferred embodiment the inert gas is helium.
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