公开(公告)号：US07348457B2

公开(公告)日：2008-03-25

申请号：US11078335

申请日：2005-03-14

申请人： Toshii Iida ,  Shoko Yamaguchi ,  Mineyuki Yokoyama ,  Yoshihiro Yokokawa ,  Koji Kobayashi

发明人： Toshii Iida ,  Shoko Yamaguchi ,  Mineyuki Yokoyama ,  Yoshihiro Yokokawa ,  Koji Kobayashi

IPC分类号： C07C233/00 ,  C07C233/45

CPC分类号： C07D491/08 ,  A01N37/46 ,  A01N43/90 ,  C07C235/76

摘要： α-Ketol unsaturated fatty acid derivatives represented by the following formula (1), α-ketol unsaturated fatty acid amide derivatives represented by the following formula (6), and plant growth regulators containing, as the active ingredient, at least one of these derivatives: wherein R1 represents linear C1-5 alkyl; R represents hydrogen, etc.; R3 represents hydrogen, etc.; R4 represents hydrogen, etc.; R5 represents hydrogen, etc.; n is an integer from 3 to 15; and the carbon atoms at the A- and B-positions may be in either (R)- or (S)-configuration; and wherein R7 represents C1-17 alkyl, etc; R8 represents hydrogen, etc.; R9 represents α-ketolalkylene; and R10 represents specific divalent linear hydrocarbyl.

摘要翻译： 由下式（1）表示的α-酮醇不饱和脂肪酸衍生物，由下式（6）表示的α-酮醇不饱和脂肪酸酰胺衍生物和含有作为活性成分的至少一种这些衍生物的植物生长调节剂 ：其中R 1表示直链C 1-5烷基; R表示氢等。 R 3表示氢等; R 4表示氢等; R 5表示氢等; n为3〜15的整数， 并且A和B位上的碳原子可以是（R） - 或（S） - 构型; 并且其中R 7表示C 1-17烷基等; R 8表示氢等; R 9表示α-酮醇亚烷基; R 10表示特定的二价直链烃基。

公开(公告)号：US08318638B2

公开(公告)日：2012-11-27

申请号：US12960656

申请日：2010-12-06

申请人： Mineyuki Yokoyama ,  Shoko Yamaguchi ,  Toshii Iida ,  Kiyotaka Kojima ,  Koji Kobayashi ,  Osamu Tanaka

发明人： Mineyuki Yokoyama ,  Shoko Yamaguchi ,  Toshii Iida ,  Kiyotaka Kojima ,  Koji Kobayashi ,  Osamu Tanaka

IPC分类号： A01N37/00 ,  A61K31/19

CPC分类号： A01N37/42

摘要： An object of the present invention is to determine novel means of activating plants; more particularly, means of controlling plant growth, such as means of promoting growth, means of controlling dormancy, means of imparting tolerance against stress for plants (dryness, high or low temperatures, osmotic pressure, etc.), and means of preventing aging. The present inventors have found that the above object can be achieved by providing plant activators containing, as an active ingredient, C4-C24 ketol fatty acids, in particular, 9-hydroxy-10-oxo-12(Z),15(Z)-octadecadienoic acid.

摘要翻译： 本发明的目的是确定活化植物的新方法; 更具体地，是控制植物生长的手段，例如促进生长的手段，控制休眠的手段，赋予植物胁迫耐受性的手段（干燥，高温或低温，渗透压等）以及防止老化的手段。 本发明人已经发现，通过提供含有作为活性成分的C4-C24酮醇脂肪酸，特别是9-羟基-10-氧代-12（Z），15（Z） 十八碳二烯酸。

公开(公告)号：US20070225380A1

公开(公告)日：2007-09-27

申请号：US10580471

申请日：2004-11-22

申请人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata ,  Keiko Takada ,  Yuji Katsuta

发明人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata ,  Keiko Takada ,  Yuji Katsuta

IPC分类号： A61K47/12

CPC分类号： A61K8/0212 ,  A61K8/44 ,  A61K8/466 ,  A61Q1/02 ,  A61Q19/00

摘要： To provide a parakeratosis inhibitor, pore reducing agent and skin roughness preventing/ameliorating agent that exhibit capabilities of parakeratosis inhibition, pore reduction, skin roughness prevention/amelioration, etc., and further provide a skin preparation for external use having these capabilities. There are provide a parakeratosis inhibitor and a pore reducing agent each comprising at least one compound selected from the group consisting of a glycine derivative, an aminodicarboxylic acid derivative, an acylaminodicarboxylic acid derivative, a pyrrolidinecarboxylic acid derivative, a piperidinecarboxylic acid derivative, a hexamethyleneiminecarboxylic acid, a beta-alanine derivative and salts of these derivatives. Further, there are provided a parakeratosis inhibitor, a pore reducing agent and a skin roughness preventing/ameliorating agent each comprising at least one compound selected from the group consisting of specified glycine derivatives and salts thereof and specified aminosulfuric acid derivatives and salts thereof. Still further, there are provided skin preparations for external use comprising these compounds.

摘要翻译： 提供表现角化不全抑制，减孔，皮肤粗糙度防止/改善等的角化不全抑制剂，减孔剂和皮肤粗糙度防止/改善剂，进一步提供具有这些能力的外用皮肤制剂。 提供了角化不全抑制剂和孔还原剂，其各自包含至少一种选自甘氨酸衍生物，氨基二羧酸衍生物，酰氨基二羧酸衍生物，吡咯烷羧酸衍生物，哌啶羧酸衍生物，六亚甲基亚氨基羧酸 ，β-丙氨酸衍生物和这些衍生物的盐。 此外，提供了分别含有选自特定的甘氨酸衍生物及其盐的化合物和规定的氨基硫酸衍生物及其盐中的至少一种化合物的角化不全抑制剂，减孔剂和皮肤粗糙度防止改善剂。 此外，提供了包含这些化合物的外用皮肤制剂。

公开(公告)号：US07026489B2

公开(公告)日：2006-04-11

申请号：US10239886

申请日：2001-03-23

申请人： Toshii Iida ,  Shoko Yamaguchi ,  Mineyuki Yokoyama ,  Yoshihiro Yokokawa ,  Koji Kobayashi ,  Osamu Tanaka

发明人： Toshii Iida ,  Shoko Yamaguchi ,  Mineyuki Yokoyama ,  Yoshihiro Yokokawa ,  Koji Kobayashi ,  Osamu Tanaka

IPC分类号： C07D209/56

CPC分类号： C07D491/08 ,  A01N37/46 ,  A01N43/90 ,  C07C235/76

摘要： α-Ketol unsaturated fatty acid derivatives represented by the following formula (1), α-ketol unsaturated fatty acid amide derivatives represented by the following formula (6), and plant growth regulators containing, as the active ingredient, at least one of these derivatives: wherein R1 represents linear C1-5 alkyl; R2 represents hydrogen, etc.; R3 represents hydrogen, etc.; R4 represents hydrogen, etc.; R5 represents hydrogen, etc.; n is an integer from 3 to 15; and the carbon atoms at the A- and B-positions may be in either (R)- or (S)-configuration; and wherein R7 represents C1-17 alkyl, etc; R8 represents hydrogen, etc.; R9 represents α-ketolalkylene; and R10 represents specific divalent linear hydrocarbyl.

摘要翻译： 由下式（1）表示的α-酮醇不饱和脂肪酸衍生物，由下式（6）表示的α-酮醇不饱和脂肪酸酰胺衍生物和含有作为活性成分的至少一种这些衍生物的植物生长调节剂 ：其中R 1表示直链C 1-5烷基; R 2表示氢等; R 3表示氢等; R 4表示氢等; R 5表示氢等; n为3〜15的整数， 并且A和B位上的碳原子可以是（R） - 或（S） - 构型; 并且其中R 7表示C 1-17烷基等; R 8表示氢等; R 9表示α-酮醇亚烷基; R 10表示特定的二价直链烃基。

公开(公告)号：US20050202974A1

公开(公告)日：2005-09-15

申请号：US11078335

申请日：2005-03-14

申请人： Toshii Iida ,  Shoko Yamaguchi ,  Mineyuki Yokoyama ,  Yoshihiro Yokokawa ,  Koji Kobayashi

发明人： Toshii Iida ,  Shoko Yamaguchi ,  Mineyuki Yokoyama ,  Yoshihiro Yokokawa ,  Koji Kobayashi

IPC分类号： A01N37/46 ,  A01N43/90 ,  C07C235/76 ,  C07D491/08 ,  A01N57/00 ,  C07D491/02

CPC分类号： C07D491/08 ,  A01N37/46 ,  A01N43/90 ,  C07C235/76

摘要： α-Ketol unsaturated fatty acid derivatives represented by the following formula (1), α-ketol unsaturated fatty acid amide derivatives represented by the following formula (6), and plant growth regulators containing, as the active ingredient, at least one of these derivatives: wherein R1 represents linear C1-5 alkyl; R represents hydrogen, etc.; R3 represents hydrogen, etc.; R4 represents hydrogen, etc.; R5 represents hydrogen, etc.; n is an integer from 3 to 15; and the carbon atoms at the A- and B-positions may be in either (R)- or (S)-configuration; and wherein R7 represents C1-17 alkyl, etc; R8 represents hydrogen, etc.; R9 represents α-ketolalkylene; and R10 represents specific divalent linear hydrocarbyl.

摘要翻译： 由下式（1）表示的α-酮醇不饱和脂肪酸衍生物，由下式（6）表示的α-酮醇不饱和脂肪酸酰胺衍生物和含有作为活性成分的至少一种这些衍生物的植物生长调节剂 ：其中R 1表示直链C 1-5烷基; R表示氢等。 R 3表示氢等; R 4表示氢等; R 5表示氢等; n为3〜15的整数， 并且A和B位上的碳原子可以是（R） - 或（S） - 构型; 并且其中R 7表示C 1-17烷基等; R 8表示氢等; R 9表示α-酮醇亚烷基; R 10表示特定的二价直链烃基。

公开(公告)号：US20120283302A1

公开(公告)日：2012-11-08

申请号：US13266663

申请日：2010-04-28

申请人： Maki Kaneko ,  Takuya Hiruma ,  Masaru Suetsugu ,  Chika Katagiri ,  Toshii Iida ,  Tomoko Onodera

发明人： Maki Kaneko ,  Takuya Hiruma ,  Masaru Suetsugu ,  Chika Katagiri ,  Toshii Iida ,  Tomoko Onodera

IPC分类号： A61K31/4166 ,  A61K31/17 ,  A61P35/00 ,  A61P19/04 ,  A61P17/08 ,  A61P17/12 ,  A61P17/06 ,  A61K31/4015 ,  A61P17/00

CPC分类号： A61K31/17 ,  A61K31/4015 ,  A61K31/4166 ,  C07D207/27 ,  C07D233/34 ,  C07D233/40

摘要： A SCCA-1 production inhibitor, comprising as an active ingredient, at least one carboxamide derivative selected from the group consisting of compounds represented by the following formula (I): wherein X is CR5 or N, R1, R4 and R5 each independently represent hydrogen, C1-C4 alkyl or a C1-C6 hydroxyalkyl group having 1-5 hydroxy groups, R2 and R3 each independently represent hydrogen, C1-C4 alkyl or a C1-C6 hydroxyalkyl group having 1-5 hydroxy groups, or each represents a group —(CH2)n—, wherein n represents an integer of 1 or 2, and may form a 5- to 6-membered ring together with the atoms to which they are bonded and with the carbonyl group, allantoin, and salts thereof.

摘要翻译： 一种SCCA-1生产抑制剂，其包含作为活性成分的至少一种选自由下式（I）表示的化合物的羧酰胺衍生物：其中X为CR 5或N，R 1，R 4和R 5各自独立地表示氢 C1-C4烷基或具有1-5个羟基的C1-C6羟基烷基，R2和R3各自独立地表示氢，C1-C4烷基或具有1-5个羟基的C1-C6羟烷基，或各自表示基团 - （CH 2）n - ，其中n表示1或2的整数，并且可以与它们所键合的原子和羰基，尿囊素及其盐一起形成5-至6-元环。

公开(公告)号：US20120253064A1

公开(公告)日：2012-10-04

申请号：US13467254

申请日：2012-05-09

申请人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata ,  Keiko Takada ,  Yuji Katsuta

发明人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata ,  Keiko Takada ,  Yuji Katsuta

IPC分类号： C07C309/26

CPC分类号： A61K8/0212 ,  A61K8/44 ,  A61K8/466 ,  A61Q1/02 ,  A61Q19/00

摘要： To provide a parakeratosis inhibitor, pore reducing agent and skin roughness preventing/ameliorating agent that exhibit capabilities of parakeratosis inhibition, pore reduction, skin roughness prevention/amelioration, etc., and further provide a skin preparation for external use having these capabilities. There are provided a parakeratosis inhibitor, a pore reducing agent and a skin roughness preventing/ameliorating agent each comprising at least one compound selected from the group consisting of specified glycine derivatives and salts thereof and specified aminosulfuric acid derivatives and salts thereof. Still further, there are provided skin preparations for external use comprising these compounds.

摘要翻译： 提供表现角化不全抑制，减孔，皮肤粗糙度防止/改善等的角化不全抑制剂，减孔剂和皮肤粗糙度防止/改善剂，进一步提供具有这些能力的外用皮肤制剂。 提供了一种角化不全抑制剂，减孔剂和皮肤粗糙度防止/改善剂，其各自包含至少一种选自指定的甘氨酸衍生物及其盐的化合物和指定的氨基硫酸衍生物及其盐。 此外，提供了包含这些化合物的外用皮肤制剂。

公开(公告)号：US20120232111A1

公开(公告)日：2012-09-13

申请号：US11920053

申请日：2006-04-28

申请人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata

发明人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata

IPC分类号： A61K31/197 ,  C07D211/34 ,  C07C237/06 ,  A61K31/164 ,  C07C229/08 ,  A61Q19/00 ,  A61K31/4439 ,  C07D211/76 ,  A61K31/4402 ,  A61K8/49 ,  A61K8/44 ,  A61P17/00 ,  A61K31/4453 ,  C07D401/04

CPC分类号： A61Q19/00 ,  A61K8/0212 ,  A61K8/44 ,  A61K8/445 ,  A61K8/447 ,  A61K8/4926 ,  A61K31/131 ,  A61K31/136 ,  A61K31/137 ,  A61Q1/02 ,  A61Q1/12

摘要： The invention provides a parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/ameliorating agent that has a function such as parakeratosis inhibition, pore shrinkage, or rough skin—inhibition/abatement, poses no safety problems such as sensory irritation, and is very safe, and further provides an external composition for skin to which a compound having the above-mentioned function has been added. The parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/ameliorating agent comprises one or more compounds selected from the group consisting of β-alanine derivatives and salts thereof. The external composition for skin comprises the one or more compounds selected from the group consisting of β-alanine derivatives and salts thereof as the above-mentioned parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/ameliorating agent.

摘要翻译： 本发明提供了具有角化不全抑制，孔收缩或粗糙皮肤抑制/消瘦等功能的角化不全抑制剂，孔收缩剂或粗糙皮肤防止/改善剂，不会引起感觉刺激等安全问题，而且 非常安全，并且还提供了已经添加了具有上述功能的化合物的皮肤的外用组合物。 角化不全抑制剂，孔收缩剂或粗糙皮肤防止/改善剂包含一种或多种选自β-丙氨酸衍生物及其盐的化合物。 用于皮肤的外用组合物包含一种或多种选自上述的角化不全抑制剂，毛孔收缩剂或粗糙皮肤防止/改善剂的组合物，其组合物包括β-丙氨酸衍生物及其盐。

公开(公告)号：US20110004019A1

公开(公告)日：2011-01-06

申请号：US12921866

申请日：2009-03-12

申请人： Toshii Iida ,  Maki Kaneko ,  Mikiko Kaminuma ,  Masaru Suetsugu

发明人： Toshii Iida ,  Maki Kaneko ,  Mikiko Kaminuma ,  Masaru Suetsugu

IPC分类号： C07C233/01 ,  C07C233/47

CPC分类号： A61Q19/007 ,  A61K8/0212 ,  A61K8/44 ,  A61K8/442 ,  A61K31/16 ,  A61K31/185 ,  A61K31/195 ,  A61K31/198 ,  A61Q1/02 ,  A61Q1/12

摘要： The present invention provides a parakeratosis inhibitor, a pore-shrinking agent, and a rough skin inhibiting or ameliorating agent comprising, as an active ingredient, a compound that has excellent effects and high safety without safety problems such as sensory irritation, and provides an external composition for skin containing the same. The compound is selected from the glutamic acid derivatives represented by formula (1) or (2) and the salts thereof: wherein A represents a carbamoyl group, a benzyloxycarbonyl group, an alkyl group having 1 to 3 carbon atoms, an allyl group, or an amidino group; wherein Z represents an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 2 to 4 carbon atoms, etc.; Y represents OH, an alkyloxy group having 1 to 3 carbon atoms, an allyloxy group, or NR3R4; R1 to R4 each independently represents H, an alkyl group having 1 to 3 carbon atoms, an allyl group, a cycloalkyl group having 3 to 7 carbon atoms, a cycloalkenyl group having 3 to 7 carbon atoms, a phenyl group, or a benzyl group, or R1 and R2, or R3 and R4, independently form a heterocycle.

摘要翻译： 本发明提供一种角化不全抑制剂，孔收缩剂和粗皮肤抑制或改善剂，其包含具有优异效果和高安全性的化合物作为活性成分，没有诸如感觉刺激之类的安全问题，并且提供外部 含有相同成分的皮肤。 该化合物选自由式（1）或（2）表示的谷氨酸衍生物及其盐：其中A表示氨基甲酰基，苄氧基羰基，具有1至3个碳原子的烷基，烯丙基或 脒基; 其中Z表示碳原子数1〜4的烷基，碳原子数2〜4的烯基等。 Y表示OH，具有1至3个碳原子的烷氧基，烯丙氧基或NR 3 R 4; R 1〜R 4各自独立地表示H，碳原子数1〜3的烷基，烯丙基，碳原子数3〜7的环烷基，碳原子数3〜7的环烯基，苯基或苄基 ，或R 1和R 2，或R 3和R 4独立地形成杂环。

公开(公告)号：US20050148474A1

公开(公告)日：2005-07-07

申请号：US11058368

申请日：2005-02-16

申请人： Mineyuki Yokoyama ,  Shoko Yamaguchi ,  Toshii Iida ,  Kiyotaka Kojima ,  Koji Kobayashi ,  Osamu Tanaka

发明人： Mineyuki Yokoyama ,  Shoko Yamaguchi ,  Toshii Iida ,  Kiyotaka Kojima ,  Koji Kobayashi ,  Osamu Tanaka

IPC分类号： A01N37/42 ,  A01N37/00

CPC分类号： A01N37/42

摘要： An object of the present invention is to determine novel means of activating plants; more particularly, means or controlling plant growth, such as means of promoting growth, means of controlling dormancy, means of imparting tolerance against stress for plants (dryness, high or low temperatures, osmotic pressure, etc.), and means of preventing aging. The present inventors have found that the above object can be achieved by providing plant activators containing, as an active ingredient, C4-C24 ketol fatty acids, in particular, 9-hydroxy-10-oxo-12(Z),15(Z)-octadecadienoic acid.

摘要翻译： 本发明的目的是确定活化植物的新方法; 更具体地说，是指或控制植物生长，例如促进生长的手段，控制休眠的手段，赋予植物胁迫耐受性的手段（干燥，高温或低温，渗透压等）以及防止老化的手段。 本发明人已经发现，上述目的可以通过提供含有作为有效成分的C 4 -C 24脂肪醇脂肪酸的植物活化剂来实现，特别是9 - 羟基-10-氧代-12（Z），15（Z） - 十八碳二烯酸。