摘要:
A can end member has a center panel, a circumferential chuck wall, and a transition wall. The center panel is centered about a longitudinal axis and has a peripheral edge. The center panel also has a step portion located radially outwardly from the longitudinal axis. The step portion has an annular convex portion joined to an annular concave portion and displaces at least a portion of the center panel vertically in a direction parallel to the longitudinal axis. The curl defines an outer perimeter of the end member. The circumferential chuck wall extends downwardly from the curl to the transition wall. The transition wall connects the chuck wall with the peripheral edge of the center panel. The transition wall has a folded portion extending outwardly relative to the longitudinal axis.
摘要:
A can end member has a center panel, a circumferential chuck wall, and a transition wall. The center panel is centered about a longitudinal axis and has a peripheral edge. The center panel also has a step portion located radially outwardly from the longitudinal axis. The step portion has an annular convex portion joined to an annular concave portion and displaces at least a portion of the center panel vertically in a direction parallel to the longitudinal axis. The curl defines an outer perimeter of the end member. The circumferential chuck wall extends downwardly from the curl to the transition wall. The transition wall connects the chuck wall with the peripheral edge of the center panel. The transition wall comprises a folded portion. The folded portion has a first leg, a second leg, and a third leg. The first leg is directly connected to the chuck wall and joined to the second leg by a concave annular portion. The second leg is joined to the third leg by a convex annular portion, and the third leg is joined to the center panel. The convex annular portion has a radius of curvature greater than 0.002 ins.
摘要:
A tensioner for imparting tension to a chain having a body, a resilient chain guide element, at least one blade spring, and at least one bracket. The body of the tensioner has a surface with a profile of the path of a new chain and a groove found longitudinally along the length of the surface. The resilient chain guide element, on the surface of the body has a chain contact surface and two ends wrapped around the ends of the body, with the chain guide being sufficiently larger than the body, such that the chain contact surface is capable of being biased away from the body. The blade spring is present in the groove with its end in the containments means of the groove, biasing the chain guide out and away from the body.
摘要:
A can end and can body are seamed to each other using a seaming roller, seaming chuck and a laser fusing the peripheral portion of the can end to the can body. Laser seaming allows less metal to be used in the can end and can body. The can end and can body seam is further reinforced in order to ensure that the can is capable of withstanding internal pressures. The reinforcing techniques include crimping the seam with one or more crimping rollers, reforming the seam so as to incline the seam towards a central axis extending through the center of the can end and can body, and using multiple laser welds spaced apart from each other in the vicinity of the seam.
摘要:
Kaiso, a transcriptional regulator with bimodal DNA-binding specificity, is over-expressed in breast cancer cells, and its nuclear localization is correlated with malignant and lymph node metastasis. Depleted expression of Kaiso in those cells results in a significant decrease in basal and EGF-induced cell migration, and this is associated with increased E-cadherin expression. The data reported and described herein provide significant evidence that Kaiso is involved in breast cancer invasion and metastasis. Kaiso nuclear localization is a biomarker that is associated with invasive and metastatic infiltrating ductal breast cancer that may be used to monitor, detect, and/or track the progress of disease in a patient.
摘要:
A single action press for forming a shell used to make a can end includes a first tool and an opposed second tool. The first tool includes a die center insert that performs a forming operation on disc cut from a sheet of end material. The first tool is configured and arranged wherein force is supplied to the die center insert during the downstroke and force is removed from the die center insert at the bottom of the downstroke and at the start of the upstroke, to thereby enable the die center insert to disengage from the shell. One specific embodiment uses a die center piston and compressed air to apply force to the die center insert. Another embodiment uses a cam and cam follower arrangement to remove axial forces at the bottom of the downstroke and either springs or gas pressure to apply force to the die center insert during the downstroke. Actuators are provided in the first tool to reestablished downward forces on the die center insert by the time the top of the upstroke so that the press cycle can be repeated.
摘要:
A function-oriented user interface presents users with selections related to what they want to do, rather than selections related to what tool they want to use. Functions may be dragged onto elements (data objects) or elements may be dragged onto functions to initiate activity. The elements themselves may present icons representing functions that are available such as adding a voice note or addressing to another person.
摘要:
There is provided a CRF receptor antagonist comprising a compound of the formula (I): A-W—Ar (I) wherein, A is a group represented by the formula (A1) or (A2): (wherein, ring Aa is a 5- or 6-membered ring which may be further substituted; ring Ab is a 5- or 6-membered ring which may be further substituted; ring Ac is a 5- or 6-membered ring which may be substituted; R1 is optionally substituted alkyl, substituted amino, substituted hydroxy, etc.; X is carbonyl, —O—, —S—, etc.; Y1, Y2 and Q are independently optionally substituted carbon or nitrogen; is a single or double bond); W is a bond, optionally substituted methylene, optionally substituted imino, —O—, —S—, etc.; Ar is optionally substituted aryl or optionally substituted heteroaryl; or a salt thereof or a prodrug thereof.
摘要:
A tensioner for imparting tension to a chain having a body, a resilient chain guide element, at least one blade spring, and at least one bracket. The body of the tensioner has a surface with a profile of the path of a new chain and a groove found longitudinally along the length of the surface. The resilient chain guide element, on the surface of the body has a chain contact surface and two ends wrapped around the ends of the body, with the chain guide being sufficiently larger than the body, such that the chain contact surface is capable of being biased away from the body. The blade spring is present in the groove with its end in the containments means of the groove, biasing the chain guide out and away from the body. At least one bracket is fixedly attached to the body and has a pivot.
摘要:
Disclosed are peptides having activity against receptor CXCR3 are disclosed that exhibit activity in preventing the formation of new vessels and activity in mediating the dissociation of newly-formed vessels and resolving of wounds in the later stages of wound healing. Preferred peptides are derived from the α-helix portion IP-10 (CXCL10) or from IP-9 (CXCL11), are nontoxic, and smaller than naturally occurring peptides, making them useful in therapies against diseases or disease states marked by unwanted angiogenesis, including tumorogenic diseases such as cancers, and in healing of chronic wounds.