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    FLUORESCENT PROBE FOR DETECTING ACTIVATION OF SIALIDASE
    11.
    发明申请
    FLUORESCENT PROBE FOR DETECTING ACTIVATION OF SIALIDASE 有权

    公开(公告)号：US20220186286A1

    公开(公告)日：2022-06-16

    申请号：US17593009

    申请日：2020-03-05

    申请人： The University of Tokyo

    发明人： Yasuteru URANO ,  Mako KAMIYA ,  Charlotte RIVAS

    IPC分类号： C12Q1/40 ,  C07H17/04

    摘要： A fluorescent probe for sialidase activity detection, is a compound represented by the following general formula or a salt thereof. R1, if present, represents the same or different monovalent substituent present on a benzene ring. R2 and R3 each independently represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or a halogen atom. R4 and R5 each independently represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or a halogen atom. R6 represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, or a fluorinated alkyl group having 1 to 5 carbon atoms. R6′ represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, and R6′ may form, together with R3 or R5 a five to seven-membered heterocyclyl or heteroaryl containing a nitrogen atom to which R6′ is bonded.

    FLUORESCENT PROBE FOR DETECTING CARBOXYPEPTIDASE ACTIVITY
    13.
    发明申请
    FLUORESCENT PROBE FOR DETECTING CARBOXYPEPTIDASE ACTIVITY 有权

    公开(公告)号：US20220017940A1

    公开(公告)日：2022-01-20

    申请号：US17298477

    申请日：2019-12-02

    申请人： The University of Tokyo

    发明人： Yasuteru URANO ,  Mako KAMIYA ,  Yugo KURIKI

    IPC分类号： C12Q1/37 ,  G01N33/542 ,  G01N21/64

    摘要： A compound is represented by the following general formula (I): The compound or a salt thereof provides a fluorescent probe for detecting carboxypeptidase activity. In the formula, R1 represents an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms; T represents an amino acid residue or a residue of an amino acid derivative; S represents a C-terminal amino acid residue. represents a fluorophore, and the fluorophore is a fluorophore in which an absorption/fluorescence wavelength greatly changes or a quenched state changes to a fluorescent state by elimination of the —P(═O)(—R1)-T-S moiety.

    FLUORESCENT PROBE FOR DETECTING DIPEPTIDYL PEPTIDASE IV
    15.
    发明申请
    FLUORESCENT PROBE FOR DETECTING DIPEPTIDYL PEPTIDASE IV 审中-公开

    公开(公告)号：US20170157272A1

    公开(公告)日：2017-06-08

    申请号：US15324147

    申请日：2015-07-10

    申请人： The University of Tokyo

    发明人： Yasuteru URANO ,  Yasuyuki SETO ,  Haruna ONOYAMA ,  Yugo KURIKI ,  Mako KAMIYA

    IPC分类号： A61K49/00 ,  A61B1/04

    CPC分类号： A61K49/0041 ,  A61B1/043 ,  A61K49/00 ,  C12M1/00

    摘要： [Problem] To provide a novel fluorescent probe for dipeptidyl peptidase IV, and a detection method and a detection kit using the fluorescent probe.[Solution] A fluorescent probe for detecting dipeptidyl peptidase IV (DPP-IV), said probe comprising a compound represented by formula (I) or a salt, thereof. In formula (I): A and B are either the same or different and independently represent an amino acid residue, provided that A is bonded via an amide bond to NH in an adjacent formula and B is bonded via an amide bond to A; R1 represents hydrogen atom(s) or 1 to 4 substituents bonded to the benzene ring, said substituents being either the same or different; R2, R3, R4, R5, R6 and R7 independently represent a hydrogen atom, a hydroxyl group, an alkyl group or a halogen atom; R8 and R9 independently represent a hydrogen atom or an alkyl group; and X represents a C1-C5 alkylene group.

    NOVEL NON-FLUORESCENT RHODAMINES
    20.
    发明申请
    NOVEL NON-FLUORESCENT RHODAMINES 有权

    公开(公告)号：US20210087160A1

    公开(公告)日：2021-03-25

    申请号：US16977437

    申请日：2019-03-04

    申请人： THE UNIVERSITY OF TOKYO

    发明人： Kenjiro HANAOKA ,  Yasuteru URANO ,  Takayuki IKENO

    IPC分类号： C07D311/82 ,  C09B11/24

    摘要： A novel non-fluorescent rhodamine dye forms a twisted intramolecular charge transfer state. A substituent that causes steric hindrance is introduced at an ortho position of a dimethylamino group on the xanthene ring of tetramethylrhodamine, which is a general rhodamine that exhibits strong fluorescence, and a certain amount of twist is imparted in a ground state. As a result, the formation of the twisted intramolecular charge transfer state is promoted in the excited state and non-fluorescence is exhibited.