公开(公告)号：US11192871B2

公开(公告)日：2021-12-07

申请号：US16712711

申请日：2019-12-12

申请人： Temple University-Of The Commonwealth System of Higher Education

发明人： Daniel J. Canney ,  Benjamin E. Blass ,  Rong Gao ,  Magid Abou-Gharbia

IPC分类号： C07D405/12 ,  A61P25/24 ,  C07D307/33 ,  C07D307/94 ,  C07D405/06 ,  C07D307/28 ,  C07D405/14

摘要： Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

公开(公告)号：US20200223810A1

公开(公告)日：2020-07-16

申请号：US16712711

申请日：2019-12-12

申请人： Temple University-Of The Commonwealth System of Higher Education

发明人： Daniel J. Canney ,  Benjamin E. Blass ,  Rong Gao ,  Magid Abou-Gharbia

IPC分类号： C07D307/33 ,  C07D307/94 ,  C07D405/06 ,  C07D405/12 ,  C07D307/28 ,  C07D405/14

摘要： Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.

公开(公告)号：US20180221365A1

公开(公告)日：2018-08-09

申请号：US15573504

申请日：2016-05-11

申请人： Temple University-Of The Commonwealth System of Higher Education

发明人： Daniel J. Canney ,  Benjamin E. Blass ,  Rong Gao ,  Kevin Blattner

IPC分类号： A61K31/496 ,  A61K31/4709 ,  A61K31/4525 ,  A61K31/4725 ,  A61P35/00

CPC分类号： A61K31/496 ,  A61K31/4525 ,  A61K31/4709 ,  A61K31/4725 ,  A61P35/00 ,  C07D307/33 ,  C07D307/94 ,  C07D405/02 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12

摘要： Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of sigma-2 receptor activity.