公开(公告)号：US07981025B2

公开(公告)日：2011-07-19

申请号：US12259965

申请日：2008-10-28

Applicant: Scott Pool ,  Blair Walker ,  Jay R. McCoy ,  Peter P. Tran ,  Richard L. Quick ,  Shahram Moaddeb ,  Arvin Chang

Inventor： Scott Pool ,  Blair Walker ,  Jay R. McCoy ,  Peter P. Tran ,  Richard L. Quick ,  Shahram Moaddeb ,  Arvin Chang

IPC: A61F2/00

CPC classification number: A61F5/0053 ,  A61F5/003 ,  A61F5/0059 ,  A61F5/0066 ,  A61F2005/002

Abstract: A system includes an adjustable implant configured for implantation internally within a subject, the adjustable implant having a permanent magnet configured for rotation about an axis of rotation, the permanent magnet operatively coupled to a drive transmission configured to alter a dimension of the adjustable implant. The system further includes an external adjustment device configured for placement on or adjacent to the skin of the subject comprising at least one magnet configured for rotation, the external adjustment device further comprising a motor configured to rotate the at least one magnet, whereby rotation of the at least one magnet of the external adjustment device effectuates rotational movement of the permanent magnet of the adjustable implant and alters the dimension of the adjustable implant. The system includes drive control circuitry configured to drive the motor of the external adjustment device to achieve a target dimension of the adjustable implant.

Abstract translation: 系统包括被配置用于在对象内部进行植入的可调节植入物，所述可调节植入物具有被配置为围绕旋转轴线旋转的永磁体，所述永磁体可操作地耦合到构造成改变可调节植入物的尺寸的驱动变速器。 所述系统还包括外部调节装置，其被配置为放置在所述对象的皮肤上或与所述对象的皮肤相邻，所述外部调节装置包括被配置为旋转的至少一个磁体，所述外部调整装置还包括被配置为旋转所述至少一个磁体的马达， 外部调节装置的至少一个磁体实现可调节植入物的永磁体的旋转运动并改变可调节植入物的尺寸。 该系统包括被配置为驱动外部调节装置的电动机以实现可调节植入物的目标尺寸的驱动控制电路。

公开(公告)号：US20100081868A1

公开(公告)日：2010-04-01

申请号：US12567532

申请日：2009-09-25

Applicant: Shahram Moaddeb ,  Samuel M. Shaolian ,  Emanuel Shaoulian ,  Richard Rhee ,  Steven C. Anderson

Inventor： Shahram Moaddeb ,  Samuel M. Shaolian ,  Emanuel Shaoulian ,  Richard Rhee ,  Steven C. Anderson

IPC: A61F2/02

CPC classification number: A61B17/00234 ,  A61B17/06166 ,  A61B17/0644 ,  A61B17/068 ,  A61B2017/00243 ,  A61B2017/00867 ,  A61B2017/06052

Abstract: Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.

Abstract translation: 提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。 通过使用形状记忆元件重建心脏解剖结构来治疗这种心脏扩张。 这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加心室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。 形状记忆元件具有原始形状和至少一种存储器形状。 当原始形状时，将元件植入心脏组织内或外部和/或内部附着到心脏的表面。 元件然后被激活以从原始形状转换到至少一个存储器形状之一。 元件的过渡导致相关的心脏组织区域重新调整位置，例如减小心室的宽度。 这种重新定位由元素随时间推移而维持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。

公开(公告)号：US07594887B2

公开(公告)日：2009-09-29

申请号：US11876586

申请日：2007-10-22

Applicant: Shahram Moaddeb ,  Samuel M. Shaolian ,  Emanuel Shaoulian ,  Richard Rhee ,  Steven C. Anderson

Inventor： Shahram Moaddeb ,  Samuel M. Shaolian ,  Emanuel Shaoulian ,  Richard Rhee ,  Steven C. Anderson

IPC: A61F2/02

CPC classification number: A61B17/00234 ,  A61B17/06166 ,  A61B17/0644 ,  A61B17/068 ,  A61B2017/00243 ,  A61B2017/00867 ,  A61B2017/06052

Abstract: Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.

Abstract translation: 提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。 通过使用形状记忆元件重建心脏解剖结构来治疗这种心脏扩张。 这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加心室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。 形状记忆元件具有原始形状和至少一种存储器形状。 当原始形状时，将元件植入心脏组织内或外部和/或内部附着到心脏的表面。 元件然后被激活以从原始形状转换到至少一个存储器形状之一。 元件的过渡导致相关的心脏组织区域重新调整位置，例如减小心室的宽度。 这种重新定位由元素随时间推移而维持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。

公开(公告)号：US20050288780A1

公开(公告)日：2005-12-29

申请号：US11124405

申请日：2005-05-06

Applicant: Richard Rhee ,  Emanuel Shaoulian ,  Shahram Moaddeb ,  Samuel Shaolian

Inventor： Richard Rhee ,  Emanuel Shaoulian ,  Shahram Moaddeb ,  Samuel Shaolian

IPC: A61F2/00 ,  A61F2/02 ,  A61F2/24

CPC classification number: A61F2/2448 ,  A61F2/2445 ,  A61F2210/0014 ,  A61F2210/0023 ,  A61F2250/0001 ,  A61F2250/0004 ,  A61F2250/0082

Abstract: Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The devices have, a first shape in a first configuration and a second shape in a second configuration and are configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion without substantially decreasing a distance between the two lateral portions.

Abstract translation: 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施例中，装置包括前部，后部和对应于前部和后部的交叉点的两个侧部。 这些装置具有第一配置中的第一形状和第二配置的第二形状，并且被配置为响应于施加到其上的激活能量而从第一配置变换到第二配置。 该变换被配置为减小前部和后部之间的距离，而基本上不减小两个侧部之间的距离。

公开(公告)号：US06671561B1

公开(公告)日：2003-12-30

申请号：US09561716

申请日：2000-05-01

Applicant: Shahram Moaddeb

Inventor： Shahram Moaddeb

IPC: A61N105

CPC classification number: A61N1/06 ,  A61B18/1492 ,  A61B2018/00154

Abstract: A catheter having an improved electrode that minimizes irritation to the heart tissue and counters the occurrence of foreign body reactions is provided. The catheter comprises an elongated, flexible catheter body having proximal and distal ends and at least one lumen extending therethrough. At least one electrode, such as a tip electrode or ring electrode, is mounted on the distal end of the catheter body, wherein the electrode comprises a base material having an outer surface and a hydrogel layer applied over at least a portion of the outer surface of the base material. Preferably a drug or other therapeutic agent is incorporated into the hydrogel layer.

Abstract translation: 提供了具有改善的电极的导管，其使对心脏组织的刺激最小化并且反映了异物反应的发生。 导管包括细长的柔性导管主体，其具有近端和远端以及延伸穿过其中的至少一个内腔。 至少一个电极，例如尖端电极或环形电极，安装在导管主体的远端上，其中电极包括基材，其具有外表面和水凝胶层，该水凝胶层涂覆在外表面的至少一部分上 的基材。 优选地，将药物或其它治疗剂并入到所述水凝胶层中。

公开(公告)号：US06475214B1

公开(公告)日：2002-11-05

申请号：US09561717

申请日：2000-05-01

Applicant: Shahram Moaddeb

Inventor： Shahram Moaddeb

IPC: A61B1818

CPC classification number: A61B18/1492 ,  A61B2018/00065 ,  A61B2018/00107 ,  A61B2018/00119 ,  A61B2018/00815 ,  A61B2018/00821

Abstract: An ablation catheter comprises an elongated, flexible catheter body having proximal and distal ends and at least one lumen extending therethrough. A tip electrode having a length of at least about 3 mm is mounted on the distal end of the catheter body. The tip electrode comprises a base material having an outer surface and a porous layer applied over at least a portion of the outer surface of the base material, the porous layer comprising metal nitride, metal oxide, metal carbide, metal carbonitride, carbon, carboxy nitride, or a combination thereof.

Abstract translation: 消融导管包括细长的柔性导管主体，其具有近端和远端以及延伸穿过其中的至少一个内腔。 具有至少约3mm长度的尖端电极安装在导管主体的远端上。 尖端电极包括具有外表面和多孔层的基材，该多孔层涂覆在基材外表面的至少一部分上，多孔层包括金属氮化物，金属氧化物，金属碳化物，金属碳氮化物，碳， ，或其组合。

公开(公告)号：US06405091B1

公开(公告)日：2002-06-11

申请号：US09359327

申请日：1999-07-20

Applicant: David J. Vachon ,  Shahram Moaddeb ,  Gene A. Bornzin ,  Kevin L. Morgan

Inventor： David J. Vachon ,  Shahram Moaddeb ,  Gene A. Bornzin ,  Kevin L. Morgan

IPC: A61N105

CPC classification number: A61N1/0565 ,  A61N1/057

Abstract: A passive fixation, body implantable lead assembly has a cylindrical tip electrode whose outer side surface is covered with a thin dielectric insulating layer so as to mask an active, disk-shaped electrode surface at the distal extremity of the tip electrode. The active electrode surface preferably has an area less than about 1 mm2. An MCRD, in the form of a collar, may be carried by a proximal portion of the tip electrode. Supplementing a set of main tines projecting from the distal end portion of an insulating sheath housing the lead assembly is a set of nubby auxiliary tines extending from the sheath immediately adjacent the distal extremity thereof.

Abstract translation: 被动固定体植入式导线组件具有圆柱形末端电极，其外侧表面被薄的电介质绝缘层覆盖，以便掩盖尖端电极的远端处的活性盘形电极表面。 活性电极表面优选具有小于约1mm 2的面积。 可以由尖端电极的近端部分承载环形形式的MCRD。 补充从套管导线组件的绝缘护套的远端部分突出的一组主尖齿是一组从紧靠其远端的护套延伸的辅助辅助齿。

公开(公告)号：US5490323A

公开(公告)日：1996-02-13

申请号：US380764

申请日：1995-01-30

Applicant: James R. Thacker ,  Alvin H. Weinberg ,  Shahram Moaddeb

Inventor： James R. Thacker ,  Alvin H. Weinberg ,  Shahram Moaddeb

IPC: A61B5/145 ,  A61B5/1459 ,  A61N1/05 ,  A61N1/365 ,  A61N1/37 ,  H01R43/00

CPC classification number: A61N1/056 ,  A61N1/36557 ,  A61N1/3702 ,  Y10T29/49117

Abstract: The present invention includes a body implantable lead having a multipolar proximal connector, at least a first conductor coupled to at least one stimulating electrode, a sensor for sensing at least one physiologic parameter of the body, and a second and a third conductor coupled to the sensor. The sensor is hermetically sealed in a D-shaped housing. Sensor components are mounted onto a microelectronic substrate which is advantageously placed on an inner flat portion of the D-shaped housing. End caps having sealing rings, either glass frit or metal, are used to seal the ends of the shell. A hermetic seal is easily achieved by heating the sealing material until they re-flow between the end caps and the shell. Advantageously, the sensor terminals are sized to fit snugly within a narrow bore of the end cap which is then circumferentially welded closed. The D-shaped sensor is placed on a carrier having at least two lumens. At least the first and second conductors pass through the lumens for connection with the stimulating electrode and the distal end of the sensor. Advantageously, the D-shaped housing reduces the area that needs to be hermetically sealed by more than half, and thus reduces the overall diameter of the lead. Advantageously, the conductors coupled to the sensor function independently from the stimulation conductors so that interference with basic operation of the pacemaker is prevented.

Abstract translation: 本发明包括具有多极近端连接器的主体可植入引线，至少一个耦合到至少一个刺激电极的第一导体，用于感测身体的至少一个生理参数的传感器，以及耦合到该主体的第二和第三导体 传感器。 传感器密封在D形外壳中。 传感器组件安装在有利地放置在D形壳体的内部平坦部分上的微电子衬底上。 用密封环（玻璃料或金属）的端盖用于密封外壳的端部。 通过加热密封材料直到它们在端盖和壳体之间再流动，容易实现气密密封。 有利地，传感器端子的尺寸设计成紧密地配合在端盖的窄孔内，然后圆形焊接封闭。 D形传感器放置在具有至少两个流明的载体上。 至少第一和第二导体穿过腔以便与刺激电极和传感器的远端连接。 有利地，D形壳体将需要被密封的面积减少一半以上，从而减小了导线的总直径。 有利地，耦合到传感器的导体独立于刺激导体起作用，从而防止对起搏器的基本操作的干扰。

公开(公告)号：US5447533A

公开(公告)日：1995-09-05

申请号：US132545

申请日：1993-10-06

Applicant: David J. Vachon ,  Shahram Moaddeb

Inventor： David J. Vachon ,  Shahram Moaddeb

IPC: A61N1/05

CPC classification number: A61N1/056 ,  A61N1/057 ,  A61N1/0575

Abstract: A pacing lead having a stylet introduced anti-inflammatory drug delivery element advanceable from the distal tip electrode. The element is preferably formed as a moldable biocompatible composite material. The element has a biocompatible matrix material which may be combined with drugs and therapeutic agents to deliver the drugs and agents by co-dissolution or diffusion to the point of either passive or active fixation. The drug delivery element may be rigid and serve to center the active fixation element, preferably a helix, for active fixation of the lead in the myocardium.

Abstract translation: 具有探针的起搏引线引入从远端末端电极可推进的抗炎药物递送元件。 该元件优选形成为可模制的生物相容性复合材料。 该元件具有生物相容的基质材料，其可与药物和治疗剂组合以通过共溶或扩散至被动或主动固定点来递送药物和试剂。 药物递送元件可以是刚性的，并且用于使活动固定元件（优选螺旋）居中以用于主动固定心肌中的铅。

公开(公告)号：US20110160719A1

公开(公告)日：2011-06-30

申请号：US12649417

申请日：2009-12-30

Applicant: Assaf Govari ,  Shahram Moaddeb ,  Michael Olen Zirkle ,  Christopher Beeckler ,  Philippa Hill ,  Andres Claudio Altmann

Inventor： Assaf Govari ,  Shahram Moaddeb ,  Michael Olen Zirkle ,  Christopher Beeckler ,  Philippa Hill ,  Andres Claudio Altmann

IPC: A61B18/18

CPC classification number: A61B18/1492 ,  A61B5/06 ,  A61B2017/00867 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00375 ,  A61B2018/00577 ,  A61B2018/1407 ,  A61B2018/1467 ,  A61B2034/2051 ,  A61B2218/002 ,  A61N1/056 ,  C08L2201/12

Abstract: A medical device includes an insertion shaft, having a longitudinal axis and having a distal end adapted for insertion into a body of a patient. A resilient end section is fixed to the distal end of the insertion shaft and is formed so as to define, when unconstrained, an arc oriented obliquely relative to the axis and having a center of curvature on the axis. One or more electrodes are disposed at respective locations along the end section.

Abstract translation: 医疗装置包括插入轴，其具有纵向轴线并且具有适于插入患者体内的远端。 弹性端部固定到插入轴的远端，并且形成为当不受约束时限定相对于轴线倾斜定向并且在轴线上具有曲率中心的电弧。 一个或多个电极设置在沿着端部的相应位置处。