公开(公告)号：US20070039887A1

公开(公告)日：2007-02-22

申请号：US11589376

申请日：2006-10-30

申请人： David Bomberger ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra

发明人： David Bomberger ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra

IPC分类号： B01D61/00

CPC分类号： B01D61/362 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/342 ,  A61M1/3468 ,  A61M1/3472 ,  A61M1/3482 ,  A61M1/3486 ,  A61M1/3496 ,  A61M1/3693 ,  A61M2202/0456 ,  A61M2202/08 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2205/3368 ,  B01D11/043 ,  B01D11/0492 ,  B01D61/246 ,  B01D63/02 ,  B01D63/046 ,  B01D2313/50

摘要： This invention is directed to systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. These systems contact a fluid with an extraction solvent, which causes the lipids in the fluid to separate from the fluid or causes lipids in the lipid-containing organisms to separate from the lipid-containing organism, using at least one hollow fiber contactor. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to a level below a particular threshold enabling the fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or be stored.

摘要翻译： 本发明涉及从流体（例如血浆）或从含脂质生物体中除去脂质的系统和方法。 这些系统与提取溶剂接触流体，其使得流体中的脂质与流体分离，或者使用至少一个中空纤维接触器使含脂质生物体中的脂质与含脂质生物体分离。 将分离的脂质从流体中除去。 将萃取溶剂从流体中除去或至少降低到低于特定阈值的水平，使得能够将流体施用于患者，而患者不经历不期望的后果。 一旦液体已经被处理，流体可以被给予捐赠流体的患者，给不同的患者或被储存。

公开(公告)号：US5547748A

公开(公告)日：1996-08-20

申请号：US182283

申请日：1994-01-14

申请人： Rodney S. Ruoff ,  Donald C. Lorents ,  Ripudaman Malhotra ,  Mark J. Dyer

发明人： Rodney S. Ruoff ,  Donald C. Lorents ,  Ripudaman Malhotra ,  Mark J. Dyer

IPC分类号： A61K33/24 ,  A61K33/26 ,  A61K47/48 ,  C01B31/02 ,  G11B5/712 ,  G11B11/105 ,  H01F1/00 ,  B32B5/16

CPC分类号： B82Y30/00 ,  A61K33/24 ,  A61K33/26 ,  A61K47/48869 ,  B82Y25/00 ,  B82Y40/00 ,  B82Y5/00 ,  C01B31/0233 ,  G11B5/712 ,  H01F1/0063 ,  C01B2202/02 ,  G11B11/10584 ,  G11B11/10586 ,  Y10T428/249994 ,  Y10T428/25 ,  Y10T428/256

摘要： Encapsulation of metals inside multilayered polyhedral shells of carbon (nanoencapsulates) is described. Many materials, such as metals and metal-carbides, can be encapsulated by the method of present invention, including metals such as lanthanides, transition metals, actinides and alloys. Some of these nanoencapsulate materials exhibit ferromagnetic and paramagnetic properties and have uses in the biomedical field as well as in recording media and composite materials.

摘要翻译： 描述了金属在多层多面体碳壳内的封装（纳米封装）。 许多材料，例如金属和金属碳化物，可以通过本发明的方法包裹，包括金属如镧系元素，过渡金属，锕系元素和合金。 这些纳米胶囊材料中的一些显示出铁磁性和顺磁性，并且在生物医学领域以及记录介质和复合材料中具有应用。

公开(公告)号：US07402246B2

公开(公告)日：2008-07-22

申请号：US11769872

申请日：2007-06-28

申请人： David C. Bomberger ,  Bryan Chavez ,  Pablo E. Garcia ,  Eric Hegwer ,  Thomas P. Low ,  Ripudaman Malhotra ,  Jeffrey J. Shimon

发明人： David C. Bomberger ,  Bryan Chavez ,  Pablo E. Garcia ,  Eric Hegwer ,  Thomas P. Low ,  Ripudaman Malhotra ,  Jeffrey J. Shimon

IPC分类号： B01D63/00 ,  B01D11/04 ,  B01D63/02 ,  B01D69/02 ,  B01D61/58

CPC分类号： B01D61/362 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/342 ,  A61M1/3468 ,  A61M1/3472 ,  A61M1/3482 ,  A61M1/3486 ,  A61M1/3496 ,  A61M1/3693 ,  A61M2202/0456 ,  A61M2202/08 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2205/3368 ,  B01D11/043 ,  B01D11/0492 ,  B01D61/246 ,  B01D63/02 ,  B01D63/046 ,  B01D2313/50

摘要： This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.

摘要翻译： 本发明涉及从流体或诸如血浆的流体中从含脂质生物体中除去脂质的系统和方法。 这些系统将流体与至少一种提取溶剂组合，其引起脂质与流体或含脂质生物分离。 将分离的脂质从流体中除去。 将至少一种提取溶剂从流体中除去或者至少减少到使得能够向患者施用流体的浓度，而不会产生不期望的后果。 一旦流体被处理，流体可以被施用给捐赠流体的患者或不同的患者进行治疗。

公开(公告)号：US07364658B2

公开(公告)日：2008-04-29

申请号：US11737939

申请日：2007-04-20

申请人： David C. Bomberger ,  Bryan Chavez ,  Pablo E. Garcia ,  Eric Hegwer ,  Thomas P. Low ,  Ripudaman Malhotra ,  Jeffrey J. Shimon

发明人： David C. Bomberger ,  Bryan Chavez ,  Pablo E. Garcia ,  Eric Hegwer ,  Thomas P. Low ,  Ripudaman Malhotra ,  Jeffrey J. Shimon

IPC分类号： B01D11/00 ,  B01D11/04 ,  B01D69/08 ,  B01D36/00 ,  B01D61/00

CPC分类号： B01D61/362 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/342 ,  A61M1/3472 ,  A61M1/3482 ,  A61M1/3486 ,  A61M1/3496 ,  A61M1/3693 ,  A61M2202/0456 ,  A61M2202/08 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2205/3306 ,  A61M2205/3331 ,  A61M2205/3334

摘要： This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.

摘要翻译： 本发明涉及从流体或诸如血浆的流体中从含脂质生物体中除去脂质的系统和方法。 这些系统将流体与至少一种提取溶剂组合，其引起脂质与流体或含脂质生物分离。 将分离的脂质从流体中除去。 将至少一种提取溶剂从流体中除去或者至少减少到使得能够向患者施用流体的浓度，而不会产生不期望的后果。 一旦流体被处理，流体可以被施用给捐赠流体的患者或不同的患者进行治疗。

公开(公告)号：US20070138094A1

公开(公告)日：2007-06-21

申请号：US11700626

申请日：2007-01-31

申请人： David Bomberger ,  Bryan Chavez ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra ,  Jeffrey Shimon

发明人： David Bomberger ,  Bryan Chavez ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra ,  Jeffrey Shimon

IPC分类号： B01D61/24

CPC分类号： B01D63/02 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3472 ,  A61M1/3482 ,  A61M1/3486 ,  A61M1/3496 ,  A61M2202/0456 ,  A61M2202/08 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2205/3306 ,  A61M2205/3368 ,  B01D11/0415 ,  B01D11/0457 ,  B01D11/0488 ,  B01D11/0492 ,  B01D61/246 ,  B01D61/36 ,  B01D2317/02 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/10 ,  B01F7/1635 ,  B01F9/02 ,  B01F11/0014 ,  B01F11/0283 ,  B01F2009/0063

摘要： Systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. A fluid is combined with at least one extraction solvent, which causes the lipids to separate from the fluid or from lipid-containing organisms. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to an acceptable concentration enabling the delipidated fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or stored for later use.

公开(公告)号：US07195710B2

公开(公告)日：2007-03-27

申请号：US10856046

申请日：2004-05-28

申请人： David C. Bomberger ,  Bryan Chavez ,  Pablo E. Garcia ,  Eric Hegwer ,  Thomas P. Low ,  Ripudaman Malhotra ,  Jeffrey J. Shimon

发明人： David C. Bomberger ,  Bryan Chavez ,  Pablo E. Garcia ,  Eric Hegwer ,  Thomas P. Low ,  Ripudaman Malhotra ,  Jeffrey J. Shimon

IPC分类号： B01D63/02 ,  B01D36/00 ,  B01D11/04 ,  B01D11/00

CPC分类号： B01D61/362 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/342 ,  A61M1/3472 ,  A61M1/3482 ,  A61M1/3486 ,  A61M1/3496 ,  A61M1/3693 ,  A61M2202/0456 ,  A61M2202/08 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2205/3306 ,  A61M2205/3331 ,  A61M2205/3334

摘要： This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.

摘要翻译： 本发明涉及从流体或诸如血浆的流体中从含脂质生物体中除去脂质的系统和方法。 这些系统将流体与至少一种提取溶剂组合，其引起脂质与流体或含脂质生物分离。 将分离的脂质从流体中除去。 将至少一种提取溶剂从流体中除去或者至少减少到使得能够向患者施用流体的浓度，而不会产生不期望的后果。 一旦流体被处理，流体可以被施用给捐赠流体的患者或不同的患者进行治疗。

公开(公告)号：US20060060520A1

公开(公告)日：2006-03-23

申请号：US11263819

申请日：2005-11-01

申请人： David Bomberger ,  Bryan Chavez ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra ,  Jeffrey Shimon

发明人： David Bomberger ,  Bryan Chavez ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra ,  Jeffrey Shimon

IPC分类号： B01D63/02

CPC分类号： B01D63/02 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3472 ,  A61M1/3482 ,  A61M1/3486 ,  A61M1/3496 ,  A61M2202/0456 ,  A61M2202/08 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2205/3306 ,  A61M2205/3368 ,  B01D11/0415 ,  B01D11/0457 ,  B01D11/0488 ,  B01D11/0492 ,  B01D61/246 ,  B01D61/36 ,  B01D2317/02 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/10 ,  B01F7/1635 ,  B01F9/02 ,  B01F11/0014 ,  B01F11/0283 ,  B01F2009/0063

摘要： Systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. A fluid is combined with at least one extraction solvent, which causes the lipids to separate from the fluid or from lipid-containing organisms. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to an acceptable concentration enabling the delipidated fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or stored for later use.

公开(公告)号：US06991727B2

公开(公告)日：2006-01-31

申请号：US11059064

申请日：2005-02-16

申请人： David C. Bomberger ,  Pablo E. Garcia ,  Eric Hegwer ,  Thomas P. Low ,  Ripudaman Malhotra

发明人： David C. Bomberger ,  Pablo E. Garcia ,  Eric Hegwer ,  Thomas P. Low ,  Ripudaman Malhotra

IPC分类号： B01D11/04 ,  A61M37/00

CPC分类号： B01D61/362 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/342 ,  A61M1/3468 ,  A61M1/3472 ,  A61M1/3482 ,  A61M1/3486 ,  A61M1/3496 ,  A61M1/3693 ,  A61M2202/0456 ,  A61M2202/08 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2205/3368 ,  B01D11/043 ,  B01D11/0492 ,  B01D61/246 ,  B01D63/02 ,  B01D63/046 ,  B01D2313/50

摘要： This invention is directed to systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. These systems contact a fluid with an extraction solvent, which causes the lipids in the fluid to separate from the fluid or causes lipids in the lipid-containing organisms to separate from the lipid-containing organism, using at least one hollow fiber contactor. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to a level below a particular threshold enabling the fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or be stored.

公开(公告)号：US5304366A

公开(公告)日：1994-04-19

申请号：US814721

申请日：1991-12-24

申请人： Donald C. Lorents ,  Ripudaman Malhotra

发明人： Donald C. Lorents ,  Ripudaman Malhotra

IPC分类号： C01B31/02 ,  C09C1/44

CPC分类号： B82Y30/00 ,  B82Y40/00 ,  C01B31/0206 ,  C01B31/0213 ,  Y10S977/845

摘要： A process and apparatus is described for the production of purified fullerenes using a non-reactive gas to collect and transport impure fullerenes from an evaporation zone to a heated filter zone in which solid impurities may be filtered out of the mixture. If one or more condensed fullerenes are present in the gas stream entering the filter zone, such condensed fullerenes may be vaporized in the filter zone and carried to a condensation zone in which one or more vaporized fullerenes may be recovered. When more than one vaporized fullerene is present in the gas entering either the filter zone or the condensation zone, a temperature gradient may be used to permit separation and recovery of purified portions of different fullerenes.

摘要翻译： 描述了使用非反应性气体来生产纯化的富勒烯的方法和装置，以将不纯的富勒烯从蒸发区收集并输送到其中可将固体杂质从混合物中过滤出的加热过滤区。 如果在进入过滤器区域的气流中存在一种或多种凝聚的富勒烯，则这种冷凝的富勒烯可以在过滤区域中蒸发并且被运送到可以回收一种或多种蒸发的富勒烯的冷凝区域。 当进入过滤区或冷凝区的气体中存在多于一个的蒸发的富勒烯时，可以使用温度梯度来允许分离和回收不同富勒烯的纯化部分。

公开(公告)号：US4417080A

公开(公告)日：1983-11-22

申请号：US386857

申请日：1982-06-10

申请人： David S. Ross ,  Robert M. Johnson, Jr. ,  Ripudaman Malhotra

发明人： David S. Ross ,  Robert M. Johnson, Jr. ,  Ripudaman Malhotra

IPC分类号： C07C201/08 ,  C07C205/06 ,  C07C79/10

CPC分类号： C07C201/08

摘要： Aromatic hydrocarbons are nitrated by reacting the aromatic hydrocarbon in a nitrogen tetroxide-containing liquid reaction medium, in the presence of a beta-dicarbonyl compound having a "W" configuration with a carbonyl group at each apex of the "W", such as a metal acetylacetonate, preferably at a pressure and temperature sufficient to maintain the nitrogen tetroxide in the liquid state. Addition of an inert organic co-solvent to the liquid nitrogen tetroxide for the metal acetylacetonate promoted nitration of benzene essentially eliminates the production of dinitrobenzenes.

摘要翻译： 在具有“W”构型的β-二羰基化合物与“W”的每个顶点具有羰基的存在下，通过使含四氧化二氮的液体反应介质中的芳族烃反应，使芳族烃硝化，例如 金属乙酰丙酮化物，优选在足以将氮氧化物保持在液态的压力和温度下。 向液态四氧化物中加入惰性有机助溶剂用于金属乙酰丙酮化物促进苯的硝化，基本上消除了二硝基苯的生成。