公开(公告)号：US10780083B1

公开(公告)日：2020-09-22

申请号：US16675982

申请日：2019-11-06

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole ,  James Lamond Ellis

IPC: A61K31/40 ,  A61K31/4453 ,  A61K31/55 ,  A61P29/00 ,  C07D207/04 ,  C07D211/06 ,  C07D223/02 ,  C07D225/02 ,  A61K31/452 ,  C07D211/14 ,  C07D207/06 ,  A61K45/06 ,  C07D223/04 ,  A61K31/395

Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof. The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

公开(公告)号：US20240277727A1

公开(公告)日：2024-08-22

申请号：US18242203

申请日：2023-09-05

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole ,  James Lamond Ellis

IPC: A61K31/55 ,  A61K31/4025 ,  A61K31/4436 ,  A61K45/06 ,  C07D409/12

CPC classification number: A61K31/55 ,  A61K31/4025 ,  A61K31/4436 ,  A61K45/06 ,  C07D409/12

Abstract: The invention provides compounds of Formula (1), or pharmaceutically acceptable salts




The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

公开(公告)号：US20240100032A1

公开(公告)日：2024-03-28

申请号：US18136517

申请日：2023-04-19

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole ,  James Lamond Ellis

IPC: A61K31/4436 ,  A61K31/415 ,  A61K31/4155 ,  A61K45/06 ,  C07D409/12

CPC classification number: A61K31/4436 ,  A61K31/415 ,  A61K31/4155 ,  A61K45/06 ,  C07D409/12

Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof:




The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, cough, itch, and neurogenic inflammation.

公开(公告)号：US20210130380A1

公开(公告)日：2021-05-06

申请号：US17090327

申请日：2020-11-05

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole ,  James Lamond Ellis

IPC: C07F9/6553 ,  C07F9/6578

Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

公开(公告)号：US20210128578A1

公开(公告)日：2021-05-06

申请号：US17098678

申请日：2020-11-16

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole ,  James Lamond Ellis

IPC: A61K31/55 ,  C07D409/12 ,  A61K45/06 ,  A61K31/4436 ,  A61K31/4025

Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

公开(公告)号：US10933055B1

公开(公告)日：2021-03-02

申请号：US16815868

申请日：2020-03-11

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole ,  James Lamond Ellis

IPC: A61K31/4436 ,  C07D409/12 ,  A61K45/06 ,  A61K31/415 ,  A61K31/4155

Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, cough, itch, and neurogenic inflammation.

公开(公告)号：US10828287B2

公开(公告)日：2020-11-10

申请号：US16676043

申请日：2019-11-06

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole ,  James Lamond Ellis

IPC: A61K31/4425 ,  C07D213/80 ,  C07D213/04 ,  A61K45/06

Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof. The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, cough, itch, and neurogenic inflammation.

公开(公告)号：US20200290953A1

公开(公告)日：2020-09-17

申请号：US16815426

申请日：2020-03-11

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole ,  James Lamond Ellis

IPC: C07C237/04 ,  C07D223/04 ,  C07D211/34 ,  C07D207/09 ,  C07D417/06 ,  C07D409/06 ,  C07D413/06 ,  C07D225/02

Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

公开(公告)号：US20230094175A1

公开(公告)日：2023-03-30

申请号：US17837129

申请日：2022-06-10

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole ,  James Lamond Ellis

IPC: C07D211/34 ,  C07C237/04 ,  C07D207/09 ,  C07D223/04 ,  C07D225/02 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06

Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

公开(公告)号：US11603355B2

公开(公告)日：2023-03-14

申请号：US17095949

申请日：2020-11-12

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole ,  James Lamond Ellis

IPC: A61K31/55 ,  A61K31/4425 ,  A61K31/452 ,  C07D207/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  C07D225/02 ,  C07D223/04 ,  C07D211/00 ,  C07D211/34 ,  C07C237/04 ,  C07D207/09 ,  A61K45/06

Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.