公开(公告)号：US12162851B2

公开(公告)日：2024-12-10

申请号：US17197732

申请日：2021-03-10

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole ,  James Lamond Ellis

IPC: C07D267/10 ,  A61K31/395 ,  A61K31/40 ,  A61K31/452 ,  A61K31/4706 ,  A61K31/5375 ,  A61K31/55 ,  A61K31/553 ,  A61K45/06 ,  A61P17/04 ,  C07D211/14 ,  C07D295/037 ,  C07D295/088

Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof. The compounds, compositions, methods and kits of the invention are particularly useful for the treatment of itch and other dermal conditions.

公开(公告)号：US11701370B2

公开(公告)日：2023-07-18

申请号：US17090160

申请日：2020-11-05

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole ,  James Lamond Ellis

IPC: A61K31/66 ,  A61K45/06 ,  C07F9/54 ,  C07F9/6568

CPC classification number: A61K31/66 ,  A61K45/06 ,  C07F9/54 ,  C07F9/5442 ,  C07F9/65688

Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof:




The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

公开(公告)号：US11696912B2

公开(公告)日：2023-07-11

申请号：US17099759

申请日：2020-11-16

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole ,  James Lamond Ellis

IPC: A61K31/4436 ,  C07D409/12 ,  A61K45/06 ,  A61K31/415 ,  A61K31/4155

CPC classification number: A61K31/4436 ,  A61K31/415 ,  A61K31/4155 ,  A61K45/06 ,  C07D409/12

Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof:




The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, cough, itch, and neurogenic inflammation.

公开(公告)号：US20220274936A1

公开(公告)日：2022-09-01

申请号：US17091064

申请日：2020-11-06

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole ,  James Lamond Ellis

IPC: C07D241/12 ,  C07D213/04 ,  C07D233/61 ,  C07D237/08 ,  C07D471/04 ,  C07D401/04 ,  C07D231/12

Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, cough, itch, and neurogenic inflammation.

公开(公告)号：US20210309623A1

公开(公告)日：2021-10-07

申请号：US17197732

申请日：2021-03-10

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole ,  James Lamond Ellis

IPC: C07D295/088 ,  C07D267/10 ,  C07D211/14 ,  A61P17/04

Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof. The compounds, compositions, methods and kits of the invention are particularly useful for the treatment of itch and other dermal conditions.

公开(公告)号：US20240116895A1

公开(公告)日：2024-04-11

申请号：US18135898

申请日：2023-04-18

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole ,  James Lamond Ellis

IPC: C07D401/12 ,  C07D207/06 ,  C07D211/14 ,  C07D211/60 ,  C07D213/56 ,  C07D223/04 ,  C07D231/12

CPC classification number: C07D401/12 ,  C07D207/06 ,  C07D211/14 ,  C07D211/60 ,  C07D213/56 ,  C07D223/04 ,  C07D231/12 ,  A61K45/06

Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof:




The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

公开(公告)号：US20240076305A1

公开(公告)日：2024-03-07

申请号：US18129168

申请日：2023-03-31

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole ,  James Lamond Ellis

IPC: C07F9/6553 ,  C07F9/6578

CPC classification number: C07F9/655345 ,  C07F9/6578 ,  A61K45/06

Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof:




The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

公开(公告)号：US11618761B2

公开(公告)日：2023-04-04

申请号：US17090327

申请日：2020-11-05

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole ,  James Lamond Ellis

IPC: C07F9/6553 ,  C07F9/6578 ,  A61K45/06

Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

公开(公告)号：US10927096B2

公开(公告)日：2021-02-23

申请号：US16815962

申请日：2020-03-11

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole ,  James Lamond Ellis

IPC: A61K31/55 ,  A61K31/4425 ,  A61K31/452 ,  A61K31/40 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/4025 ,  A61K31/415 ,  C07D207/08 ,  C07D207/16 ,  C07D211/14 ,  C07D211/34 ,  C07D237/04 ,  C07D295/037 ,  C07D207/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  C07D225/02 ,  C07D223/04 ,  C07D211/00 ,  C07D231/12 ,  C07D213/02 ,  C07D401/06 ,  C07D401/12 ,  C07D211/60 ,  C07D213/56 ,  A61K45/06

Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

公开(公告)号：US10786485B1

公开(公告)日：2020-09-29

申请号：US16676073

申请日：2019-11-06

Applicant: Nocion Therapeutics, Inc.

Inventor： Bridget McCarthy Cole ,  James Lamond Ellis

IPC: A61K31/415 ,  A61K45/06 ,  C07D231/12

Abstract: The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof. The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, cough, itch, and neurogenic inflammation.