公开(公告)号：US20160075665A1

公开(公告)日：2016-03-17

申请号：US14888306

申请日：2014-05-01

Applicant: Sanjay GARG ,  Martine KEENAN ,  Adam MCCLUSKEY ,  Andrew STEVENS ,  NEOCULI PTY LTD

Inventor： Stephen Page ,  Sanjay Garg ,  Martine Keenan ,  Adam McCluskey ,  Andrew Stevens

IPC: C07D239/50 ,  A01N47/44 ,  A61K45/06 ,  A01N43/54 ,  A61K31/505 ,  C07C281/18 ,  A61K31/155

CPC classification number: C07D239/50 ,  A01N43/54 ,  A01N47/44 ,  A61K31/14 ,  A61K31/155 ,  A61K31/17 ,  A61K31/175 ,  A61K31/381 ,  A61K31/404 ,  A61K31/505 ,  A61K45/06 ,  C07C281/08 ,  C07C281/16 ,  C07C281/18 ,  C07C323/45 ,  C07C337/08 ,  C07D209/14 ,  C07D209/40 ,  C07D213/53 ,  C07D215/12 ,  C07D239/48 ,  C07D251/48 ,  C07D251/54 ,  C07D251/66 ,  C07D295/125 ,  C07D307/56 ,  C07D333/58 ,  C07F9/6512 ,  A61K2300/00

Abstract: The invention provides compounds of Formula (I), and methods of treating or preventing a bacterial infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a bacterial infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a bacterial infection in a subject and to a medical device comprising the composition of the invention.

Abstract translation: 本发明提供式（I）化合物，以及使用式（I）化合物治疗或预防受试者细菌感染的方法。 本发明还提供式（I）化合物在制备用于治疗受试者的细菌感染的药物中的用途。 本发明还提供了用于治疗或预防受试者的细菌感染的方法中的医疗装置以及包含本发明的组合物的医疗装置。

公开(公告)号：US20230310388A1

公开(公告)日：2023-10-05

申请号：US17996655

申请日：2021-04-23

Applicant: Neoculi Pty Ltd

Inventor： Stephen Page ,  Adam McCluskey ,  Martine Keenan ,  Andrew Stevens ,  Sanjay Garg

IPC: A61K31/433 ,  A61K31/498 ,  A61K31/428 ,  A61K31/4709 ,  A61K31/4164 ,  A61K31/245 ,  A61P31/10

CPC classification number: A61K31/433 ,  A61K31/498 ,  A61K31/428 ,  A61K31/4709 ,  A61K31/4164 ,  A61K31/245 ,  A61P31/10

Abstract: Provided herein are methods of treating or preventing a fungal colonisation or infection in a subject. The method includes administering a therapeutically effective amount of a compound, or a therapeutically acceptable salt thereof, to the subject, wherein the fungal colonisation or infection is caused by a fungal agent. In certain embodiments, the compound is a compound of Formula I, or a stereoisomer, tautomer, pharmaceutically acceptable salt, or prodrug thereof:

公开(公告)号：US10829468B2

公开(公告)日：2020-11-10

申请号：US16892661

申请日：2020-06-04

Applicant: Neoculi Pty Ltd.

Inventor： Stephen Page ,  Andrew Stevens ,  Adam McCluskey ,  Martine Keenan ,  Rebecca Abraham

IPC: C07D333/58 ,  C07C211/29 ,  C07C281/18 ,  A61K31/155 ,  A61K31/341 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/496 ,  A61K31/498 ,  A61K31/381 ,  C07D239/50 ,  C07D295/135 ,  A61K31/17 ,  A61K31/4192 ,  A61K31/44 ,  C07C47/565 ,  C07C251/24 ,  C07D209/14 ,  C07D239/48 ,  C07D241/20 ,  C07D249/14 ,  C07D251/54 ,  C07D307/56 ,  C07D311/58 ,  C07D401/14 ,  A61K9/00 ,  A61K31/505 ,  A61K45/06 ,  C07C335/40 ,  C07D209/08

Abstract: The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a protozoan infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a protozoan infection in a subject and to a medical device comprising the composition of the invention.

公开(公告)号：US20200102287A1

公开(公告)日：2020-04-02

申请号：US16699476

申请日：2019-11-29

Applicant: Neoculi Pty Ltd.

Inventor： Stephen Page ,  Andrew Stevens ,  Adam McCluskey ,  Martine Keenan ,  Rebecca Abraham

IPC: C07D333/58 ,  A61K31/17 ,  A61K31/341 ,  A61K31/4045 ,  A61K31/4192 ,  A61K31/44 ,  A61K31/498 ,  C07C47/565 ,  C07C211/29 ,  C07C251/24 ,  C07D209/14 ,  C07D239/48 ,  C07D241/20 ,  C07D249/14 ,  C07D251/54 ,  C07D307/56 ,  C07D311/58 ,  C07D401/14 ,  A61K31/155 ,  A61K31/381 ,  C07C281/18 ,  C07D239/50 ,  C07D295/135 ,  A61K9/00 ,  A61K31/404 ,  A61K31/496 ,  A61K31/505 ,  A61K45/06 ,  C07C335/40 ,  C07D209/08

Abstract: The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a protozoan infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a protozoan infection in a subject and to a medical device comprising the composition of the invention.

公开(公告)号：US20190330178A1

公开(公告)日：2019-10-31

申请号：US16505049

申请日：2019-07-08

Applicant: Neoculi Pty Ltd.

Inventor： Stephen Page ,  Andrew Stevens ,  Adam McCluskey ,  Martine Keenan ,  Rebecca Abraham

IPC: C07D333/58 ,  A61K31/17 ,  A61K31/505 ,  A61K45/06 ,  C07D209/08 ,  C07C335/40 ,  A61K31/496 ,  A61K9/00 ,  C07C47/565 ,  C07D209/14 ,  C07D239/50 ,  C07C211/29 ,  C07D401/14 ,  C07C251/24 ,  C07D241/20 ,  C07C281/18 ,  A61K31/498 ,  A61K31/44 ,  A61K31/4192 ,  A61K31/4045 ,  A61K31/381 ,  A61K31/341 ,  A61K31/155 ,  C07D307/56 ,  C07D295/135 ,  C07D251/54 ,  C07D249/14 ,  C07D239/48 ,  C07D311/58 ,  A61K31/404

Abstract: The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a protozoan infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a protozoan infection in a subject and to a medical device comprising the composition of the invention.