公开(公告)号：US20130164383A1

公开(公告)日：2013-06-27

申请号：US13821617

申请日：2011-10-11

申请人： Koichi Masuda ,  Mitsuru Naiki

发明人： Koichi Masuda ,  Mitsuru Naiki

IPC分类号： A61K35/36

CPC分类号： C12Q1/025 ,  A61K35/32 ,  A61K35/36 ,  A61K35/76 ,  G01N33/5082 ,  G01N2333/07

摘要： The synthesis of collagen and proteoglycan in chondrocytes, such as intervertebral disc cells, articular chondrocytes and meniscal cells is promoted by administration of an extract from inflamed tissue inoculated with vaccinia virus.

摘要翻译： 软骨细胞如椎间盘细胞，关节软骨细胞和半月板细胞中的胶原和蛋白聚糖的合成通过施用痘苗病毒接种的发炎组织的提取物来促进。

公开(公告)号：US06627194B1

公开(公告)日：2003-09-30

申请号：US08694315

申请日：1996-08-08

申请人： Haruo Yoshii ,  Mitsuru Naiki ,  Yuriko Fukata

发明人： Haruo Yoshii ,  Mitsuru Naiki ,  Yuriko Fukata

IPC分类号： A61K39395

CPC分类号： C07K16/18 ,  A61K38/00 ,  Y10S424/81 ,  Y10S530/868

摘要： Activated immunoglobulin which is useful as an eosinophilia-suppressing agent, immunomodulating agent, therapeutic agent for autoimmune diseases, anfiinflammatory agent and antiallergic agent is obtained by admixing immunoglobulin with a histamine component and then substantially or completely removing the histamine component. The histamine component may be removed or separated by dialysis, gel filtration, adsorption chromatography, ion exchange chromatography, or affinity chromatography. The method imparts pharmacological activity which is not inherently available in immunoglobulin of the natural type to immunoglobulin. The activated immunoglobulin of the present invention has an immunomodulating action which is clearly different from that of conventional immunosuppressive agents. It is useful as a therapeutic agent for autoimmune diseases such as chronic rheumatoid arthritis, systemic lupus erythematodes and multiple sclerosis as well as for various immunodeficiency syndromes wherein the immune system is not functioning properly. The activated immunoglobulin of the present invention may be also used as a pharmaceutical agent for eosinophilia caused by infectious diseases, parasitic diseases, diseases of respiratory organs, autoimmune diseases, malignant tumors, etc. In addition, the product of the invention may be used as an excellent antiinflammatory agent and antiallergic agent, and so is highly useful as a pharmaceutical.

摘要翻译： 通过将免疫球蛋白与组胺成分混合，然后基本上或完全除去组胺成分，得到可用作嗜酸性粒细胞增多抑制剂，免疫调节剂，自身免疫性疾病治疗剂，抗炎药和抗过敏药物的活性免疫球蛋白。 组胺组分可以通过透析，凝胶过滤，吸附色谱，离子交换层析或亲和层析来去除或分离。 该方法赋予在天然免疫球蛋白免疫球蛋白免疫球蛋白中本身不具有的药理学活性。 本发明的活化免疫球蛋白具有与常规免疫抑制剂明显不同的免疫调节作用。 它可用作自身免疫疾病如慢性类风湿性关节炎，系统性红斑狼疮和多发性硬化以及各种免疫缺陷综合征的治疗剂，其中免疫系统不能正常运作。 本发明的活化免疫球蛋白也可以用作由感染性疾病，寄生虫病，呼吸器官疾病，自身免疫性疾病，恶性肿瘤等引起的嗜酸性粒细胞增多的药剂。此外，本发明的产品可以用作 优异的抗炎剂和抗过敏剂，因此作为药物是非常有用的。

公开(公告)号：US5532271A

公开(公告)日：1996-07-02

申请号：US301398

申请日：1994-09-08

申请人： Mitsuru Naiki ,  Yuichi Takeoka ,  Seishi Suehiro

发明人： Mitsuru Naiki ,  Yuichi Takeoka ,  Seishi Suehiro

IPC分类号： A61K31/365 ,  A61K31/34

CPC分类号： A61K31/365

摘要： The present invention relates to a method for preventing or treating autoimmune diseases in a mammal which comprises administering to the mammal an effective amount of at least one furanone derivative of the formula (I): ##STR1## wherein X is hydrogen, hydroxy, a lower alkyl group or a lower alkylene group; Y is hydrogen, hydroxy or a lower alkyl group; Z is hydrogen, a lower alkyl group or a lower hydroxyalkyl group; and the broken line represents the presence or absence of a second bond;or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明涉及一种用于预防或治疗哺乳动物中的自身免疫性疾病的方法，其包括对哺乳动物施用有效量的至少一种式（I）的呋喃酮衍生物：其中X是氢，羟基 ，低级烷基或低级亚烷基; Y是氢，羟基或低级烷基; Z是氢，低级烷基或低级羟烷基; 虚线表示存在或不存在第二键; 或其药学上可接受的盐。

公开(公告)号：US5376682A

公开(公告)日：1994-12-27

申请号：US950563

申请日：1992-09-25

申请人： Mitsuru Naiki ,  Yuichi Takeoka ,  Seishi Suehiro

发明人： Mitsuru Naiki ,  Yuichi Takeoka ,  Seishi Suehiro

IPC分类号： A61K31/365 ,  A61K31/34

CPC分类号： A61K31/365

摘要： The present invention relates to a method for reducing or treating inflammation in a mammal which comprises administering to the mammal an effective amount of at least one furanone derivative of the formula (I): ##STR1## wherein X is hydrogen, hydroxy, a lower alkyl group or a lower alkylene group; Y is hydrogen, hydroxy or a lower alkyl group; Z is hydrogen, a lower alkyl group or a lower hydroxyalkyl group; and the broken line represents the presence or absence of a second bond; or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明涉及一种用于减少或治疗哺乳动物炎症的方法，其包括向哺乳动物施用有效量的至少一种式（I）的呋喃酮衍生物：其中X是氢，羟基， 低级烷基或低级亚烷基; Y是氢，羟基或低级烷基; Z是氢，低级烷基或低级羟烷基; 虚线表示存在或不存在第二键; 或其药学上可接受的盐。