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公开(公告)号：US07838213B2
公开(公告)日：2010-11-23
申请号：US12136942
申请日：2008-06-11
Applicant: Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel , Merrill Schaeffer
Inventor： Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel , Merrill Schaeffer
IPC: C12Q1/70
CPC classification number: A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
Abstract: The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
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公开(公告)号：US20080279889A1
公开(公告)日：2008-11-13
申请号：US12137105
申请日：2008-06-11
Applicant: Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel , Merrill Schaeffer
Inventor： Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel , Merrill Schaeffer
CPC classification number: A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
Abstract: The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
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公开(公告)号：US20080267995A1
公开(公告)日：2008-10-30
申请号：US12137086
申请日：2008-06-11
Applicant: Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel , Merrill Schaeffer
Inventor： Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel , Merrill Schaeffer
CPC classification number: A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
Abstract: The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
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公开(公告)号：US20080260779A1
公开(公告)日：2008-10-23
申请号：US12136923
申请日：2008-06-11
Applicant: Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel , Merrill Schaeffer
Inventor： Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel , Merrill Schaeffer
CPC classification number: A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
Abstract: The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
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公开(公告)号：US20080181910A1
公开(公告)日：2008-07-31
申请号：US11617435
申请日：2006-12-28
Applicant: Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel , Merrill Schaeffer
Inventor： Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel , Merrill Schaeffer
CPC classification number: A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
Abstract: The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
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Patent Agency Ranking
16.发明申请MULTIVALENT PCV2 IMMUNOGENIC COMPOSITIONS AND METHODS OF PRODUCING SUCH COMPOSITIONS 审中-公开多功能PCV2免疫组合物及其制备方法公开(公告)号：US20120107348A1
公开(公告)日：2012-05-03
申请号：US13346134
申请日：2012-01-09
Applicant: Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel
Inventor： Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel
IPC: A61K39/295 , A61P37/04 , A61K39/12
CPC classification number: A61K39/12 , A61K38/00 , A61K39/04 , A61K49/0004 , A61K2039/545 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C07K14/005 , C12N2750/10034 , C12N2750/14043 , C12N2770/10034
Abstract: An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. Also provided is recombinant PCV2 ORF2 protein, and immunogenic compositions comprising PCV2 ORF2 protein. Moreover, multivalent combination vaccines are provided which include an immunological agent effective for reducing the incidence of or lessening the severity of PCV2 infection, preferably PCV2 ORF2 protein, or an immunogenic composition comprising PCV2 ORF2 protein, and at least one immunogenic active component of another disease-causing organism in swine,
Abstract translation: 提供了一种用于从猪圆环病毒2型开放阅读框架2回收蛋白质的改进方法。 还提供重组PCV2 ORF2蛋白和包含PCV2 ORF2蛋白的免疫原性组合物。 此外，提供了多价组合疫苗，其包括有效降低PCV2感染的严重性（优选PCV2 ORF2蛋白）或包含PCV2 ORF2蛋白的免疫原性组合物的发生率或降低的免疫学试剂，以及至少一种其它疾病的免疫原性活性成分 在猪中有机体，
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17.发明授权Use of a PCV2 immunogenic composition for lessening clinical symptoms in pigs 有权使用PCV2免疫原性组合物来减轻猪的临床症状公开(公告)号：US07838214B2
公开(公告)日：2010-11-23
申请号：US12137067
申请日：2008-06-11
Applicant: Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel , Merrill Schaeffer
Inventor： Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel , Merrill Schaeffer
IPC: C12Q1/70
CPC classification number: A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
Abstract: The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
Abstract translation: 本发明涉及包含用于治疗几种临床表现（疾病）的猪圆环病毒2型（PCV2）抗原的免疫原性组合物的用途。 优选地，临床表现与PCV2感染相关。 优选地，它们包括淋巴结病，淋巴细胞减少和/或多核/巨细胞组织细胞。 此外，临床症状包括与猪中的一种或多种以下症状相结合的淋巴结病：（1）间质性肺炎与小叶间水肿，（2）皮肤苍白或黄疸，（3）斑驳萎缩性肝脏，（4）胃溃疡 ，（5）肾炎和（6）生殖障碍，例如 流产，死胎，木乃伊等。此外，临床症状包括Pia样病变，通常已知与细胞内劳森氏菌感染有关。
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公开(公告)号：US07829273B2
公开(公告)日：2010-11-09
申请号：US12137141
申请日：2008-06-11
Applicant: Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel , Merrill Schaeffer
Inventor： Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel , Merrill Schaeffer
IPC: C12Q1/68
CPC classification number: A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
Abstract: The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
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19.发明申请PCV2 MYCOPLASMA HYOPNEUMONIAE IMMUNOGENIC COMPOSITIONS AND METHODS OF PRODUCING SUCH COMPOSITIONS 审中-公开PCV2 MYCOPLASMA HYOPNEUMONIAE IMMUNOGENIC COMPOSITIONS AND METHODS OF PRODUCTING OF THAT COMPOSITIONS公开(公告)号：US20090317423A1
公开(公告)日：2009-12-24
申请号：US12359023
申请日：2009-01-23
Applicant: Michael Roof , Marc Eichmeyer
Inventor： Michael Roof , Marc Eichmeyer
IPC: A61K39/295
CPC classification number: A61K39/12 , A61K39/0208 , A61K39/0241 , A61K39/39 , A61K2039/525 , A61K2039/545 , A61K2039/552 , A61K2039/55555 , A61K2039/70 , C12N7/00 , C12N2750/10034 , C12N2750/10071
Abstract: Multivalent combination vaccines are provided which include an immunological agent effective for reducing the incidence of or lessening the severity of M. hyo infection, preferably M. hyo bacterin, or an immunogenic composition comprising M. hyo bacterin, and at least one immunogenic active component of another disease-causing organism in swine, preferably PCV2 wherein the preferred PCV2 antigen for such a multivalent vaccine is PCV2 ORF 2 protein.
Abstract translation: 提供了多价组合疫苗，其包括有效减少猪尾杆菌感染的发生率或降低其重要性的免疫学试剂，优选猪尾杆菌属细菌，或包含猪肺炎支原体菌的免疫原性组合物，和至少一种免疫原性活性成分 猪中另一种致病生物，优选PCV2，其中用于这种多价疫苗的优选PCV2抗原是PCV2 ORF 2蛋白。
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公开(公告)号：US20080261887A1
公开(公告)日：2008-10-23
申请号：US12136942
申请日：2008-06-11
Applicant: Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel , Merrill Schaeffer
Inventor： Michael Roof , Phillip Hayes , Marc Eichmeyer , Greg Nitzel , Merrill Schaeffer
CPC classification number: A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
Abstract: The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
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