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公开(公告)号：US20090312307A1
公开(公告)日：2009-12-17
申请号：US12538955
申请日：2009-08-11
申请人： John Lloyd , Yoon T. Jeon , Heather Finlay , Lin Yan , Michael F. Gross , Serge Beaudoin
发明人： John Lloyd , Yoon T. Jeon , Heather Finlay , Lin Yan , Michael F. Gross , Serge Beaudoin
IPC分类号： A61K31/55 , C07D409/04 , A61K31/4535 , A61K31/497 , C07D401/06 , A61K31/4725 , C07D401/12 , A61P9/00
CPC分类号： C07D211/26 , C07D211/34 , C07D211/62 , C07D211/64 , C07D211/96 , C07D223/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Novel heterocyclo compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current IKur), methods of using such compounds in the prevention and treatment of arrhythmia and IKur-associated conditions, and pharmaceutical compositions containing such compounds.
摘要翻译： 可用作钾通道功能抑制剂的新型杂环化合物（特别是电压门控K +通道的Kv1亚族抑制剂，特别是与超快速活化延迟整流剂K +当前IKur连接的抑制剂Kv1.5），使用这些化合物的方法 在预防和治疗心律失常和IKur相关病症中，以及含有这些化合物的药物组合物。
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公开(公告)号：US07244744B2
公开(公告)日：2007-07-17
申请号：US10286662
申请日：2002-11-01
IPC分类号： A61K31/445 , C07D401/04
CPC分类号： C07D401/04 , A61K31/00 , A61K31/4439 , C07D401/14 , C07D405/14 , C07D413/14
摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides substituted piperidines, and compositions containing these compounds. Also provided are methods using the compounds of the invention for the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.
摘要翻译： 提供的化合物，组合物和方法可用于通过电压依赖性钠通道抑制钠离子通量来治疗疾病。 更具体地说，本发明提供取代的哌啶和含有这些化合物的组合物。 还提供了使用本发明化合物治疗中枢性或周围神经系统疾病，特别是疼痛和慢性疼痛的方法，其通过阻断与所述病症的发作或复发有关的钠通道。 本发明的化合物，组合物和方法特别用于通过包含PN3亚基的通道抑制离子通量来治疗神经性或炎性疼痛。
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公开(公告)号：US07223782B2
公开(公告)日：2007-05-29
申请号：US10286304
申请日：2002-11-01
IPC分类号： A61K31/4155 , C07D231/12 , C07D231/14
CPC分类号： C07D231/14 , C07D231/40 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazole-amides and -sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.
摘要翻译： 提供的化合物，组合物和方法可用于通过电压依赖性钠通道抑制钠离子通量来治疗疾病。 更具体地，本发明提供了可用于治疗中枢性或周围神经系统疾病，特别是疼痛和慢性疼痛的吡唑酰胺和磺酰胺，组合物和方法，其通过阻断与指定条件的发作或复发有关的钠通道。 本发明的化合物，组合物和方法特别用于通过包含PN3亚基的通道抑制离子通量来治疗神经性或炎性疼痛。
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公开(公告)号：US06881753B2
公开(公告)日：2005-04-19
申请号：US10823987
申请日：2004-04-14
申请人： John Lloyd , Heather J. Finlay , Wayne Vaccaro , Karnail S. Atwal , Michael F. Gross , Kerry L. Spear
发明人： John Lloyd , Heather J. Finlay , Wayne Vaccaro , Karnail S. Atwal , Michael F. Gross , Kerry L. Spear
IPC分类号： A61K31/277 , A61K31/352 , A61K31/353 , A61K31/381 , A61K31/42 , A61K31/429 , A61K31/436 , A61K31/472 , A61K31/496 , A61K31/506 , A61P9/06 , C07C303/40 , C07C311/20 , C07D215/42 , C07D311/68 , C07D401/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/12 , C07D473/38 , C07D491/04 , C07D491/052 , C07D493/04 , C07D513/04 , C07C279/28 , A61K31/155 , C07C279/18
CPC分类号： C07D409/14 , C07C311/20 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D215/42 , C07D311/68 , C07D401/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/12 , C07D473/38 , C07D491/04 , C07D493/04 , C07D513/04
摘要： Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure: where A, B, D, Q, X1, R, R1, X2 and R2 are as defined herein. These compounds are useful as antiarrhythmic agents. In addition, a method is provided for preventing cardiac arrhythmia employing the above compounds.
摘要翻译： 茚，苯并吡喃及其类似物是IKur的钾通道抑制剂和阻断剂，并具有以下结构：其中A，B，D，Q，X 1，R 1，R 1， X 2和R 2如本文所定义。 这些化合物可用作抗心律失常药。 此外，提供了一种用于预防使用上述化合物的心律失常的方法。
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公开(公告)号：US06989398B2
公开(公告)日：2006-01-24
申请号：US10770658
申请日：2004-02-02
IPC分类号： A61K31/44 , C07D401/02 , C07D213/02
CPC分类号： C07D213/75 , A61K31/00 , A61K31/44 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Benzanilides are provided which are voltage-dependent potassium channel openers. Methods of using the benzanilides of the invention are also provided.
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公开(公告)号：US06737422B2
公开(公告)日：2004-05-18
申请号：US10004122
申请日：2001-11-01
IPC分类号： A61K3144
CPC分类号： C07D213/75 , A61K31/00 , A61K31/44 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Benzanilides are provided which are voltage-dependent potassium channel openers. Methods of using the benzanilides of the invention are also provided.
摘要翻译： 提供了依赖于电压的钾通道开放剂的苯甲酰苯胺。 还提供了使用本发明的苯甲酰苯胺的方法。
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公开(公告)号：US06620849B2
公开(公告)日：2003-09-16
申请号：US09910818
申请日：2001-07-24
IPC分类号： A01N3712
CPC分类号： C07D213/40 , C07D233/64 , C07D409/12
摘要： Compounds which are useful as potassium channel inhibitors and which because of their slow off-rates are especially useful for the treatment of cardiac arrhythmias are described.
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公开(公告)号：US06605725B2
公开(公告)日：2003-08-12
申请号：US10002800
申请日：2001-11-02
IPC分类号： C07D40102
CPC分类号： C07D213/75 , A61K31/00 , A61K31/44 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Benzanilides are provided which are voltage-dependent potassium channel openers. Methods of using the benzanilides of the invention are also provided.
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公开(公告)号：US07743516B2
公开(公告)日：2010-06-29
申请号：US12143957
申请日：2008-06-23
申请人： Michael F. Gross
发明人： Michael F. Gross
CPC分类号： E04F21/003 , E04F19/02 , E04F21/0015 , E04F21/0038
摘要： A trim installation tool, attachable to the jamb of a window or door, which aids in the installation of trim. The tool provides for the marking of a consistent reveal around a door or window when installing trim. The tool also provides a surface which may be used to provide support to the end of a tape measure when performing measurements. Additionally, the tool may provide support for the trim being installed around the door or window.
摘要翻译： 一个装饰安装工具，可附连到窗户或门的侧栏，这有助于安装装饰。 该工具用于在安装装饰件时标记一个围绕门或窗的一致显示。 该工具还提供了一个表面，当执行测量时，该表面可用于为卷尺的末端提供支撑。 此外，该工具可以为安装在门或窗周围的装饰提供支撑。
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公开(公告)号：US07435824B2
公开(公告)日：2008-10-14
申请号：US11028399
申请日：2005-01-03
申请人： Michael F. Gross , John Lloyd
发明人： Michael F. Gross , John Lloyd
IPC分类号： C07D401/02 , C07D251/02 , A61K31/445
CPC分类号： C07D211/34 , C07D211/26 , C07D211/62 , C07D211/64 , C07D211/96 , C07D223/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Compounds useful as prodrugs of potassium channel inhibitor compounds, in particular as prodrugs of Kv1.5 channel inhibitors.
摘要翻译： 可用作钾通道抑制剂化合物前药的化合物，特别是作为Kv1.5通道抑制剂的前药。
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