公开(公告)号：US20180050022A1

公开(公告)日：2018-02-22

申请号：US15681478

申请日：2017-08-21

Applicant: MERCK SHARP & DOHME CORP.

Inventor： Dong-Ming Shen ,  Rongze Kuang ,  Puneet Kumar ,  Joseph L. Duffy ,  Cheng Zhu ,  Amjad Ali ,  Meng Yang ,  John S. Debenham

IPC: A61K31/435 ,  C07D213/89

CPC classification number: A61K31/435 ,  A61K2121/00 ,  C07D213/89

Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.

公开(公告)号：US09815796B2

公开(公告)日：2017-11-14

申请号：US15107233

申请日：2014-12-17

Applicant: Merck Sharp & Dohme Corp. ,  MSD R & D (China) Co. Ltd.

Inventor： Dong Ming Shen ,  Melissa Egbertson ,  Richard Berger ,  XiaoXia Qian ,  Yimin Qian ,  Bart Harper ,  Meng Yang ,  Zack Zhiqiang Guo ,  Vanessa L. Rada ,  Deping Wang ,  Timothy A. Cernak ,  Christopher Sinz ,  Ming Wang ,  Jonathan E. Wilson ,  Shimin Xu

IPC: C07D239/36 ,  C07D401/12 ,  C07D401/06 ,  C07D403/04 ,  C07D403/14 ,  C07D487/04 ,  C07D405/12 ,  C07D405/14 ,  C07D413/04 ,  C07D417/04 ,  C07D403/12 ,  C07D403/06

CPC classification number: C07D239/36 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/04 ,  C07D417/04 ,  C07D487/04

Abstract: Disclosed are pyrimidine carboxamide compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2), pharmaceutical compositions and uses thereof.