公开(公告)号：US20030138570A1

公开(公告)日：2003-07-24

申请号：US10026069

申请日：2001-12-21

Applicant: Kimberly-Clark Worldwide, Inc.

Inventor： Rosann Kaylor ,  Stephen Quirk ,  Chibueze O. Chidebelu-Eze

IPC: B05D001/28 ,  B05D005/00 ,  B05D003/02

CPC classification number: G01N33/54366

Abstract: The present invention provides a simple, reliable, and inexpensive process for the manufacture of diagnostic biosensor films such as diffraction-based diagnostic films. The present invention includes a method for preparing a diffraction-based diagnostic biosensor film that includes the steps of: a) providing a receptor solution that includes a receptor and a carrier fluid, b) applying the receptor solution to a printing cylinder having a longitudinal axis and an engraved pattern of cells, each cell having a width, height, and depth for acceptance of the receptor solution, the printing cylinder being rotated about the longitudinal axis, c) transferring the receptor solution from the rotating printing cylinder to a substrate, and, d) drying the printed substrate, wherein the dried receptor forms a pattern that includes individual printed areas having a center-to-center spacing ranging from about 0.1 microns to about 100 microns.

Abstract translation: 本发明提供了用于制造诸如衍射型诊断膜的诊断性生物传感器膜的简单，可靠且廉价的方法。 本发明包括一种制备基于衍射的诊断生物传感器膜的方法，包括以下步骤：a）提供包含受体和载体流体的受体溶液，b）将受体溶液施加到具有纵轴的印刷滚筒 和细胞的雕刻图案，每个单元具有用于接收受体溶液的宽度，高度和深度，印刷滚筒围绕纵向轴线旋转，c）将受体溶液从旋转印刷滚筒转移到基底，以及 ，d）干燥印刷的基底，其中干燥的受体形成包括具有约0.1微米至约100微米的中心到中心间隔的单独印刷区域的图案。