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15 条记录 (耗时 0.066 秒)

    Gene disruptions, compositions and methods relating thereto
    11.
    发明授权
    Gene disruptions, compositions and methods relating thereto 失效
    基因破坏，组合物和方法

    公开(公告)号：US08207396B2

    公开(公告)日：2012-06-26

    申请号：US13031009

    申请日：2011-02-18

    申请人： Bobby Joe Payne ,  Mary Jean Sparks ,  Wen Xiong

    发明人： Bobby Joe Payne ,  Mary Jean Sparks ,  Wen Xiong

    IPC分类号： G01N33/00

    CPC分类号： C12N15/8509 ,  A01K2217/075 ,  A01K2267/0306 ,  A01K2267/0362 ,  A01K2267/0375

    摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

    摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供转基因小鼠，其包括在PRO226，​​PRO257，PRO268，PRO290，PRO36006，PRO363，PRO365，PRO382，PRO444，PRO705，PRO1071，PRO1125，PRO1134，PRO1155，PRO1281，PRO1343，PRO1379，PRO1380，PRO1387，PRO1419中的中断 ，PRO1433，PRO1474，PRO1550，PRO1571，PRO1572，PRO1759，PRO1904，PRO35193，PRO4341，PRO4348，PRO4369，PRO4381，PRO4407，PRO4425，PRO4985，PRO4989，PRO5737，PRO5800，PRO5993，PRO6017，PRO7174，PRO9744，PRO9821，PRO9852，PRO9873 ，PRO10196，PRO34778，PRO20233，PRO21956，PRO57290，PRO38465，PRO38683或PRO85161基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

    Method to improve system DMA mapping while substantially reducing memory fragmentation
    15.
    发明申请
    Method to improve system DMA mapping while substantially reducing memory fragmentation 失效
    改进系统DMA映射同时显着减少内存碎片的方法

    公开(公告)号：US20070245041A1

    公开(公告)日：2007-10-18

    申请号：US11385926

    申请日：2006-03-21

    申请人： Binh Hua ,  Hong Hua ,  Dirk Michel ,  Wen Xiong

    发明人： Binh Hua ,  Hong Hua ,  Dirk Michel ,  Wen Xiong

    IPC分类号： G06F13/28

    CPC分类号： G06F13/28

    摘要： A method, system and computer program product for eliminating the latency in searching for contiguous memory space by an IO DMA request of a device driver. Three new application programming interfaces (APIs) are provided within the operating system (OS) code that allows the device driver(s) to (1) pre-request and pre-allocate the IO DMA address range from the OS during the IPL and maintain control of the address, (2) map a system (virtual/physical) address range to a specific pre-allocated IO DMA address range, and (3) free the pre-allocated IO DMA address space back to the kernel when the space is no longer required. Utilizing these APIs enables advanced IO DMA address mapping techniques maintained by the device drivers, and the assigned/allocated IO DMA address space is no longer fragmented, and the latency of completing the IO DMA mapping is substantially reduced/eliminated.

    摘要翻译： 一种方法，系统和计算机程序产品，用于消除通过设备驱动程序的IO DMA请求搜索连续存储器空间的延迟。 在操作系统（OS）代码中提供了三个新的应用编程接口（API），允许设备驱动程序（1）在IPL期间从OS预先请求并预分配IO DMA地址范围并维护 控制地址，（2）将系统（虚拟/物理）地址范围映射到特定的预先分配的IO DMA地址范围，以及（3）当空间为空时将预分配的IO DMA地址空间释放回内核 不再需要。 利用这些API可以实现由设备驱动程序维护的高级IO DMA地址映射技术，并且分配/分配的IO DMA地址空间不再分段，并且完全减少/消除了完成IO DMA映射的延迟。