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公开(公告)号：US10011654B2
公开(公告)日：2018-07-03
申请号：US14491641
申请日：2014-09-19
Applicant: GENENTECH, INC.
Inventor： David P. Arnott , Austin L. Gurney , Philip E. Hass , James M. Lee , Yan Wu
IPC: A61K39/395 , C07K16/24 , C07K14/54 , G01N33/68
CPC classification number: C07K16/244 , A61K38/00 , C07K14/54 , C07K2317/21 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/75 , C07K2317/76 , G01N33/6869 , Y02A50/463 , Y02A50/473
Abstract: The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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公开(公告)号：US20180057589A1
公开(公告)日：2018-03-01
申请号：US15656967
申请日：2017-07-21
Applicant: Genentech, Inc.
Inventor： Christian W. Siebel , Yan Wu
CPC classification number: C07K16/28 , A61K2039/505 , C07K16/30 , C07K16/3053 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: The invention provides anti-Notch antibodies, and in particular, antibodies that bind Notch2 NRR, and methods of using the same.
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公开(公告)号：US20180009894A1
公开(公告)日：2018-01-11
申请号：US15657472
申请日：2017-07-24
Applicant: Genentech, Inc.
Inventor： Bing Zheng , Andrew Polson , Cecilia Chiu , Wei-Ching Liang , Yan Wu
IPC: C07K16/28 , C07K16/30 , A61K31/706 , A61K51/10 , G01N33/574 , A61K31/5517
CPC classification number: C07K16/2851 , A61K31/5517 , A61K31/706 , A61K47/68 , A61K47/6817 , A61K47/6867 , A61K47/6889 , A61K51/1069 , A61K51/1093 , C07K16/3061 , C07K2317/14 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , G01N33/57426 , G01N2333/7056
Abstract: The invention provides anti-CLL-1 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US20170204175A9
公开(公告)日：2017-07-20
申请号：US14298488
申请日：2014-06-06
Applicant: Genentech, Inc.
Inventor： Christian W. Siebel , Yan Wu
CPC classification number: C07K16/28 , A61K2039/505 , C07K16/30 , C07K16/3053 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: The invention provides anti-Notch antibodies, and in particular, antibodies that bind Notch2 NRR, and methods of using the same.
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公开(公告)号：US20170166636A1
公开(公告)日：2017-06-15
申请号：US15349757
申请日：2016-11-11
Applicant: Genentech, Inc.
Inventor： Yan Wu , Weilan Ye , Jeremy Bryant Burton , Cecilia Chiu
IPC: C07K16/28
CPC classification number: C07K16/28 , A61K39/395 , A61K47/6849 , A61K2039/505 , A61P9/10 , A61P27/02 , C07H21/04 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/567 , C07K2317/75 , C07K2317/92
Abstract: The invention provides anti-LRP5 antibodies and methods of making and using the same.
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Patent Agency Ranking
公开(公告)号：US20170058049A1
公开(公告)日：2017-03-02
申请号：US15234649
申请日：2016-08-11
Applicant: Genentech, Inc.
Inventor： Jasvinder Atwal , Yongmei Chen , Cecilia Pui Chi Chiu , Robert A. Lazarus , Weiru Wang , Ryan J. Watts , Yan Wu , Yingnan Zhang
CPC classification number: C07K16/40 , A61K39/3955 , A61K47/6871 , A61K2039/505 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/573
Abstract: The invention provides antibodies to specific neural proteins and methods of using the same.
Abstract translation: 本发明提供了针对特定神经蛋白的抗体及其使用方法。
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公开(公告)号：US09562099B2
公开(公告)日：2017-02-07
申请号：US14207878
申请日：2014-03-13
Applicant: Genentech, Inc.
Inventor： Steven R. Leong , Andrew Polson , Paul Polakis , Yan Wu , Wei-Ching Liang , Ron Firestein
IPC: C07K16/28 , A61K47/48 , A61K45/06 , G01N33/574 , A61K51/10 , A61K39/395 , A61K39/00
CPC classification number: C07K16/3015 , A61K31/5377 , A61K31/5517 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/2827 , C07K16/3069 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/567 , C07K2317/77 , C07K2317/92 , G01N33/57492 , A61K2300/00
Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗B7-H4抗体和免疫缀合物及其使用方法。
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公开(公告)号：US20170002074A1
公开(公告)日：2017-01-05
申请号：US15171128
申请日：2016-06-02
Applicant: GENENTECH, INC.
Inventor： Shang-Fan Yu , Wei-Ching Liang , Yan Wu , Steven Leong , Andrew Polson
IPC: C07K16/28 , G01N33/574 , A61K47/48
CPC classification number: C07K16/2803 , A61K47/6809 , A61K47/6849 , A61K2039/505 , C07K2317/33 , C07K2317/73 , C07K2317/77 , C07K2317/92 , G01N33/57492 , G01N2333/70596 , G01N2458/00
Abstract: The invention provides anti-CD33 antibodies and immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗CD33抗体和免疫缀合物及其使用方法。
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公开(公告)号：US09533042B2
公开(公告)日：2017-01-03
申请号：US14177452
申请日：2014-02-11
Applicant: Genentech, Inc.
Inventor： Christian W. Siebel , Yan Wu
IPC: A61K39/395 , C07K16/28 , C07K16/30 , A61P35/00 , A61K45/06 , C07K16/18 , C07K14/705 , C07K14/71 , C07K14/715 , A61K39/00
CPC classification number: C07K16/30 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/705 , C07K14/71 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K16/3015 , C07K2317/14 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N5/10 , C12N5/12 , C12N15/09 , C12N15/63 , C12N2330/50
Abstract: The invention provides anti-Notch1 NRR antibodies, and compositions comprising and methods of using these antibodies.
Abstract translation: 本发明提供抗Notch1NRR抗体，以及包含使用这些抗体的组合物。
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公开(公告)号：US09499623B2
公开(公告)日：2016-11-22
申请号：US14887042
申请日：2015-10-19
Applicant: GENENTECH, INC.
Inventor： Avi Ashkenazi , Jing Qing , Christian Wiesmann , Yan Wu
IPC: A61K39/00 , A61K39/395 , C07K16/28
CPC classification number: C07K16/2863 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K2039/505 , C07K16/3038 , C07K16/3061 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30
Abstract: The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.
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