-
![1-(chloromethyl)-2,3-dihydro-1H-benzo[E]indole dimer antibody-drug conjugate compounds, and methods of use and treatment](/abs-image/US/2019/10/15/US10442836B2/abs.jpg.150x150.jpg)
公开(公告)号：US10442836B2
公开(公告)日：2019-10-15
申请号：US14305643
申请日：2014-06-16
Applicant: Genentech, Inc.
Inventor： John Flygare , Thomas Pillow , Brian Safina , Vishal Verma , Binqing Wei , William Denny , Anna Giddens , Ho Lee , Guo-Liang Lu , Christian Miller , Gordon Rewcastle , Moana Tercel , Muriel Bonnet
IPC: A61K47/68 , C07K16/28 , C07D207/40 , C07D209/60 , C07K5/062 , C07D487/04 , C07D209/62 , C07D401/14 , C07D403/14 , C07F9/6558 , C07H15/24 , C07K16/32 , C07D401/12 , C07D471/04 , C07K16/00 , C07K16/30 , A61K47/55 , C07F9/572 , C07F9/6561
Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.
-
Patent Agency Ranking
公开(公告)号：US20180085470A1
公开(公告)日：2018-03-29
申请号：US15834740
申请日：2017-12-07
Applicant: Genentech, Inc.
Inventor： Eric J. Brown , John Flygare , Wouter Hazenbos , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC: A61K31/7056 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , C07K16/12 , A61K38/12 , A61K31/7048 , A61K31/4709
CPC classification number: A61K47/6849 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12 , A61K47/6801 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K47/6851 , C07K16/1271 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
Abstract: The invention provides anti-wall teichoic acid antibodies, antibiotic-linker intermediates, and antibody-antibiotic conjugate compound, and methods of making and using the same.
-
公开(公告)号：US09895450B2
公开(公告)日：2018-02-20
申请号：US14945716
申请日：2015-11-19
Applicant: Genentech, Inc.
Inventor： Eric J. Brown , John Flygare , Wouter Hazenbos , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC: A61K39/395 , A61K47/48 , C07K16/12 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12
CPC classification number: A61K47/6849 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12 , A61K47/6801 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K47/6851 , C07K16/1271 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
Abstract: The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
-
公开(公告)号：US09803002B2
公开(公告)日：2017-10-31
申请号：US14292289
申请日：2014-05-30
Applicant: Genentech, Inc.
Inventor： Eric J. Brown , Martine Darwish , John Flygare , Wouter Hazenbos , Byoung Chul Lee , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC: A61K39/40 , C07K16/12 , A61K31/5386 , A61K45/06 , A61K31/4025 , A61K47/68
CPC classification number: C07K16/1271 , A61K31/4025 , A61K31/5386 , A61K39/40 , A61K45/06 , A61K47/6809 , A61K47/6835 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
Abstract: The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
-
公开(公告)号：US20160279260A1
公开(公告)日：2016-09-29
申请号：US15181825
申请日：2016-06-14
Applicant: Genentech, Inc.
Inventor： John Flygare , Janet Gunzner-Toste , Thomas Pillow , Brian Safina , Vishal Verma , Binqing Wei , Guiling Zhao , Leanna Staben
CPC classification number: A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K47/6889 , C07K16/28 , C07K16/2851 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/76
Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.
Abstract translation: 本发明涉及肽模拟接头及其抗体药物偶联物，含有它们的药物组合物及其在治疗中用于预防或治疗癌症的用途。
-
公开(公告)号：US20140356376A1
公开(公告)日：2014-12-04
申请号：US14292289
申请日：2014-05-30
Applicant: Genentech, Inc.
Inventor： Eric J. Brown , Martine Darwish , John Flygare , Wouter Hazenbos , Byoung Chul Lee , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC: C07K16/12 , A61K31/4025 , A61K47/48 , A61K45/06 , A61K39/40 , A61K31/5386
CPC classification number: C07K16/1271 , A61K31/4025 , A61K31/5386 , A61K39/40 , A61K45/06 , A61K47/6809 , A61K47/6835 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
Abstract: The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
-
-
-
-
-
Search Results
16
records
(took 0.033 seconds)
