公开(公告)号：US10058613B2

公开(公告)日：2018-08-28

申请号：US15281830

申请日：2016-09-30

Applicant: Genentech, Inc.

Inventor： Peter Dragovich ,  Thomas Pillow ,  Jack Sadowsky ,  Mark X. Sliwkowski ,  BinQing Wei

IPC: C07K16/00 ,  A61K45/06 ,  C07K16/28 ,  C07D519/00 ,  C07K16/32 ,  A61K31/5517 ,  A61K47/68

CPC classification number: A61K45/06 ,  A61K31/5517 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6889 ,  C07D519/00 ,  C07K16/2803 ,  C07K16/32 ,  C07K2317/40 ,  C07K2317/522 ,  C07K2317/567

Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a pyrrolobenzodiazepine drug moiety via a disulfide linker, pyrrolobenzodiazepine linker-drug intermediates, and methods of using the antibody-drug conjugates.