公开(公告)号：US20210163530A1

公开(公告)日：2021-06-03

申请号：US17152874

申请日：2021-01-20

申请人： Fujifilm Diosynth Biotechnologies UK Limited

发明人： Charles Heise ,  Tibor Nagy

IPC分类号： C07K1/34

摘要： A method of concentration of a liquid comprising a biomolecule is provided. The method comprises passing the liquid through a tangential flow filtration device under pressure, wherein the pressure applied is varied between at least a higher pressure and a lower pressure. Preferably, the variation in pressure is delivered by the use of a variable flow-controller, such as a valve.

公开(公告)号：US20200269190A1

公开(公告)日：2020-08-27

申请号：US16864234

申请日：2020-05-01

申请人： Fujifilm Diosynth Biotechnologies UK Limited

发明人： Charles Heise ,  Tibor Nagy

IPC分类号： B01D61/18 ,  B01D61/20 ,  C07K1/14 ,  C12N15/10 ,  B01D61/14 ,  B01D61/16

摘要： Apparatus for in-line liquid exchanging a biomolecule-containing liquid is provided. The apparatus comprises a means for mixing at least two liquids comprising a multiple inlet flow-controller, the means for mixing also comprising an outlet in fluid connection with a tangential flow filtration device configured in single-pass mode.

公开(公告)号：US10682610B2

公开(公告)日：2020-06-16

申请号：US16068465

申请日：2016-12-19

申请人： Fujifilm Diosynth Biotechnologies UK Limited

发明人： Charles Heise ,  Tibor Nagy

IPC分类号： B01D61/18 ,  B01D61/20 ,  C07K1/14 ,  C12N15/10 ,  B01D61/14 ,  B01D61/16 ,  B01D61/22

摘要： Apparatus for in-line liquid exchanging a biomolecule-containing liquid is provided. The apparatus comprises a means (3) for mixing at least two liquids comprising a multiple inlet flow-controller (2), the means for mixing also comprising an outlet in fluid connection with a tangential flow filtration device (1) configured in single-pass mode.