公开(公告)号：US5456679A

公开(公告)日：1995-10-10

申请号：US352268

申请日：1994-12-07

申请人： Stephen M. Balaban ,  James B. Pike ,  Jonathan P. Smith ,  Clifton A. Baile

发明人： Stephen M. Balaban ,  James B. Pike ,  Jonathan P. Smith ,  Clifton A. Baile

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61M5/145

CPC分类号： A61K9/0004 ,  A61M5/14526 ,  A61M2005/14513 ,  A61M2206/10

摘要： Delivery devices which include a beneficial agent and an activating mechanism in separate compartments separated by a moveable partition are designed to deliver the beneficial agent in a pulsatile manner through an orifice. The pulsatile delivery is achieved by a band of resilient material which is placed over the orifice. The resilient material is sufficiently tight to substantially seal the orifice when the pressure within the device is below a threshold level while at the same time being capable of being stretched when the internal pressure exceeds the threshold.

摘要翻译： 包括有益剂和活化机构的输送装置被设计成以可动的方式通过孔传送有益剂。 脉动输送通过放置在孔口上方的弹性材料带来实现。 当装置内的压力低于阈值水平时，同时能够在内部压力超过阈值时拉伸，弹性材料足够紧密以基本上密封孔口。

公开(公告)号：US3978221A

公开(公告)日：1976-08-31

申请号：US555337

申请日：1975-03-04

申请人： Clifton A. Baile ,  William D. Kingsbury ,  Roger C. Parish

发明人： Clifton A. Baile ,  William D. Kingsbury ,  Roger C. Parish

IPC分类号： A23K1/16 ,  A61K31/445 ,  A61K31/40

CPC分类号： A23K20/132

摘要： Compositions and methods for inducing polyphagia or eating in meat producing animals comprise administering orally or preferably by injection an effective but nontoxic subpharmacodynamic quantity of a benzhydryl ether active ingredient. Preferred active ingredients are tropine benzohydryl ether, 3-quinuclidinyl benzohydryl ether or their nontoxic acid addition salts.

公开(公告)号：US3932637A

公开(公告)日：1976-01-13

申请号：US490813

申请日：1974-07-22

申请人： Hisao Yamamoto ,  Shigeho Inaba ,  Mitsuhiro Akatsu ,  Clifton A. Baile ,  Roger G. Parish

发明人： Hisao Yamamoto ,  Shigeho Inaba ,  Mitsuhiro Akatsu ,  Clifton A. Baile ,  Roger G. Parish

IPC分类号： A23K1/16 ,  A61K31/55 ,  A61P3/00 ,  A61K31/33 ,  A61K31/44

CPC分类号： A61K31/55 ,  A23K20/116 ,  A23K20/137

摘要： Compositions and methods for inducing polyphagia in immature meat producing animals comprise administering orally or by injection an effective but nontoxic subpharmacodynamic quantity of a 1,4-benzodiazepinone active ingredient whose structure is characterized by an 1-alkyl-sulfonylalkyl moiety. Preferred active ingredients are 1-(ethylsulfonylethyl)-5-(o-halophenyl)-7-halo-1,3-dihydro-2H-1,4-benzodiazepin-2-ones.

摘要翻译： 在未成熟肉生产动物中诱导多食的组合物和方法包括口服或注射有效但无毒的亚药效动力学量的1,4-苯并二氮杂酮活性成分，其结构由1-烷基 - 磺酰基烷基部分表征。 优选的活性成分是1-（乙基磺酰基乙基）-5-（邻卤苯基）-7-卤代-1,3-二氢-2H-1,4-苯并二氮杂-2-酮。