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公开(公告)号：US20220033854A1
公开(公告)日：2022-02-03
申请号：US17503656
申请日：2021-10-18
Applicant: CORNING INCORPORATED
Abstract: The present disclosure relates to method and compositions for generating proteins. In particular, the present disclosure relates to electroporation mediated gene delivery in the generation of recombinant proteins (e.g., drug metabolizing enzyme and transporter vesicles) in mammalian cells.
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公开(公告)号：US11180777B2
公开(公告)日：2021-11-23
申请号：US16510115
申请日：2019-07-12
Applicant: Corning Incorporated
Abstract: The present disclosure relates to method and compositions for generating proteins. In particular, the present disclosure relates to electroporation mediated gene delivery in the generation of recombinant proteins (e.g., drug metabolizing enzyme and transporter vesicles) in mammalian cells.
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公开(公告)号：US20200239539A1
公开(公告)日：2020-07-30
申请号：US16851634
申请日：2020-04-17
Applicant: CORNING INCORPORATED
Inventor： Na Li , Christopher Jerome Patten , Jie Wang
IPC: C07K14/705 , G05B15/02 , G08B13/00 , G08B13/196 , G08B25/00 , G08B25/08 , G08B29/18 , C12N15/85 , A01N1/02 , C12N5/00 , C12N5/071 , G01N33/50
Abstract: The present invention discloses cryopreserved recombinant cells for screening drug candidates that transiently overexpress one or more drug transporter proteins and/or drug metabolizing enzymes. Advantageously, such cells provide a cost-efficient consumable product that streamlines the process of screening whether drug candidates are substrates or inhibitors of drug transporter proteins and/or drug metabolizing enzymes.
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公开(公告)号：US20200002726A1
公开(公告)日：2020-01-02
申请号：US16510115
申请日：2019-07-12
Applicant: Corning Incorporated
Abstract: The present disclosure relates to method and compositions for generating proteins. In particular, the present disclosure relates to electroporation mediated gene delivery in the generation of recombinant proteins (e.g., drug metabolizing enzyme and transporter vesicles) in mammalian cells.
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公开(公告)号：US20180346931A1
公开(公告)日：2018-12-06
申请号：US15778763
申请日：2016-11-22
Applicant: Corning Incorporated
CPC classification number: C12N15/85
Abstract: The present disclosure relates to method and compositions for generating proteins. In particular, the present disclosure relates to electroporation mediated gene delivery in the generation of recombinant proteins (e.g., drug metabolizing enzyme and transporter vesicles) in mammalian cells.
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Patent Agency Ranking
公开(公告)号：US20180265562A1
公开(公告)日：2018-09-20
申请号：US15988802
申请日：2018-05-24
Applicant: Corning Incorporated
Inventor： Na Li , Jie Wang , Christopher J. Patten
CPC classification number: C07K14/705 , A01N1/021 , A01N1/0284 , C12N5/00 , C12N5/067 , C12N5/069 , C12N15/85 , C12N2510/00 , G01N33/5008 , G01N2333/705
Abstract: The present invention discloses cryopreserved recombinant cells for screening drug candidates that transiently overexpress one or more drug transporter proteins and/or drug metabolizing enzymes. Advantageously, such cells provide a cost-efficient consumable product that streamlines the process of screening whether drug candidates are substrates or inhibitors of drug transporter proteins and/or drug metabolizing enzymes.
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公开(公告)号：US20170355746A1
公开(公告)日：2017-12-14
申请号：US15688983
申请日：2017-08-29
Applicant: Corning Incorporated
Inventor： Na Li , Jie Wang , Christopher J. Patten
CPC classification number: C07K14/705 , A01N1/021 , A01N1/0284 , C12N5/00 , C12N5/067 , C12N5/069 , C12N15/85 , C12N2510/00 , G01N33/5008 , G01N2333/705
Abstract: The present invention discloses cryopreserved recombinant cells for screening drug candidates that transiently overexpress one or more drug transporter proteins and/or drug metabolizing enzymes. Advantageously, such cells provide a cost-efficient consumable product that streamlines the process of screening whether drug candidates are substrates or inhibitors of drug transporter proteins and/or drug metabolizing enzymes.
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公开(公告)号：US09771409B2
公开(公告)日：2017-09-26
申请号：US15163218
申请日：2016-05-24
Applicant: Corning Incorporated
Inventor： Na Li , Jie Wang , Christopher J. Patten
CPC classification number: C07K14/705 , A01N1/021 , A01N1/0284 , C12N5/00 , C12N5/067 , C12N5/069 , C12N15/85 , C12N2510/00 , G01N33/5008 , G01N2333/705
Abstract: The present invention discloses cryopreserved recombinant cells for screening drug candidates that transiently overexpress one or more drug transporter proteins and/or drug metabolizing enzymes. Advantageously, such cells provide a cost-efficient consumable product that streamlines the process of screening whether drug candidates are substrates or inhibitors of drug transporter proteins and/or drug metabolizing enzymes.
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19.发明申请ASSAY-READY RECOMBINANT CELLS TRANSIENTLY OVEREXPRESSING GENES ENCODING DRUG TRANSPORTER PROTEINS AND/OR DRUG METABOLIZING ENZYMES 审中-公开测定再生细胞瞬时过表达编码药物转运蛋白和/或药物代谢酶的基因公开(公告)号：US20170067909A1
公开(公告)日：2017-03-09
申请号：US15269045
申请日：2016-09-19
Applicant: Corning Incorporated
Inventor： Na Li , Jie Wang , Christopher J. Patten
IPC: G01N33/68 , C07K14/705 , G01N33/50 , A01N1/02
CPC classification number: C07K14/705 , A01N1/0221 , A01N1/0284 , C12N2510/00
Abstract: Recombinant cells including one or more transiently overexpressed genes encoding a drug transporter protein, wherein the recombinant cell is cryopreserved and activity of the drug transporter protein is detectable in a population of the recombinant cells prior to cryopreservation at an uptake ratio of at least 5. Processes of preparing cryopreserved transiently transfected recombinant cells, including transiently transfecting cells with one or more genes encoding a drug transporter protein and cryopreserving the transiently transfected recombinant cells within 48 hours of transfection. A population of the transiently transfected recombinant cells transiently overexpress the one or more genes encoding the drug transporter protein at a detectable level prior to cryopreserving and the detectable level is an uptake ratio of at least 5.
Abstract translation: 包含编码药物转运蛋白的一个或多个瞬时过表达基因的重组细胞，其中重组细胞被冷冻保存，并且在至少5的摄取比例下在冷冻保存之前在重组细胞群中检测到药物转运蛋白的活性。 制备冷冻保存的瞬时转染的重组细胞，包括用编码药物转运蛋白的一种或多种基因瞬时转染细胞，并在转染48小时内冷冻保存瞬时转染的重组细胞。 瞬时转染的重组细胞的群体在冷冻保存之前以可检测水平瞬时过表达编码药物转运蛋白的一种或多种基因，并且可检测水平为至少5的摄取比。
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公开(公告)号：US20160102131A1
公开(公告)日：2016-04-14
申请号：US14972012
申请日：2015-12-16
Applicant: Corning Incorporated
Inventor： Na Li , Jie Wang , Christopher J. Patten
IPC: C07K14/705 , A01N1/02 , C12N15/85
CPC classification number: C07K14/705 , A01N1/021 , A01N1/0284 , C12N5/00 , C12N5/067 , C12N5/069 , C12N15/85 , C12N2510/00 , G01N33/5008 , G01N2333/705
Abstract: The present invention discloses cryopreserved recombinant cells for screening drug candidates that transiently overexpress one or more drug transporter proteins and/or drug metabolizing enzymes. Advantageously, such cells provide a cost-efficient consumable product that streamlines the process of screening whether drug candidates are substrates or inhibitors of drug transporter proteins and/or drug metabolizing enzymes.
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