公开(公告)号：US20190387745A1

公开(公告)日：2019-12-26

申请号：US16391272

申请日：2019-04-22

Applicant: ContraFect Corporation

Inventor： Raymond SCHUCH ,  Robert C. NOWINSKI ,  Michael WITTEKIND ,  Babar KHAN ,  Jimmy ROTOLO

IPC: A01N63/00 ,  C07K14/315 ,  A61L29/16 ,  A61L29/08 ,  A61K45/06 ,  A61K38/47 ,  A61K38/16 ,  C12N9/50

Abstract: The present invention provides methods for the prevention, control, disruption and treatment of bacterial biofilms with lysin, particularly lysin having capability to kill Staphlococcal bacteria, including drug resistant Staphylococcus aureus, particularly the lysin PlySs2. The invention also provides compositions and methods for use in treatment or modulation of bacterial biofilm(s) and biofilm formation.

公开(公告)号：US20190070269A1

公开(公告)日：2019-03-07

申请号：US15760283

申请日：2016-09-16

Applicant: ContraFect Corporation

Inventor： Raymond SCHUCH ,  Simon HOFFENBERG ,  Michael WITTEKIND

IPC: A61K38/47 ,  A61K45/06 ,  A61P31/04 ,  A61K38/12 ,  C12N9/36

Abstract: The present disclosure provides methods and compositions useful for the prophylactic and therapeutic amelioration and treatment of infections caused by Gram negative bacteria, including Pseudomonas aeruginosa. The disclosure further provides compositions and methods of incorporating and utilizing lysin polypeptides of the present disclosure for augmenting the efficacy of antibiotics generally suitable for the treatment of Gram-negative bacterial infection.