公开(公告)号：US20190177365A1

公开(公告)日：2019-06-13

申请号：US16029776

申请日：2018-07-09

Applicant: CARA THERAPEUTICS, INC.

Inventor： Claudio D. Schteingart ,  Frédérique Menzaghi ,  Guangcheng Jiang ,  Roberta Vezza Alexander ,  Javier Sueiras-Diaz ,  Robert H. Spencer ,  Derek T. Chalmers ,  Zhiyong Luo

IPC: C07K5/107 ,  C07K5/103 ,  C07K7/06 ,  C07K5/117

Abstract: The invention relates to synthetic peptide amide ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. The synthetic peptide amides of the invention conform to the structure: The compounds are useful in the prophylaxis and treatment of pain and inflammation associated with a variety of diseases and conditions.