公开(公告)号：US11875549B2

公开(公告)日：2024-01-16

申请号：US17424172

申请日：2021-01-13

Applicant: BOE Technology Group Co., Ltd.

Inventor： Qiong Wu ,  Zijian Zhao ,  Yongming Shi ,  Jijing Huang ,  Dawei Tang ,  Zongmin Liu

IPC: G06V10/28 ,  G06T5/30

CPC classification number: G06V10/28 ,  G06T5/30 ,  G06T2207/20036 ,  G06V2201/07

Abstract: A data processing method for a biochip comprises: acquiring a biochip image to be detected; performing binarization processing on the biochip image to obtain a binary image; performing a morphological dilation operation on the binary image in a row direction to obtain a first image, and performing a morphological dilation operation on the binary image in a column direction to obtain a second image; performing connected domain detection on the first image in the row direction, and performing connected domain detection on the second image in the column direction, to determine the number of rows and the number of columns of a sample point array and center position information of each sample point.

公开(公告)号：US11591370B2

公开(公告)日：2023-02-28

申请号：US16646320

申请日：2019-08-22

Applicant: BEIJING BOE TECHNOLOGY DEVELOPMENT CO., LTD. ,  BOE TECHNOLOGY GROUP CO., LTD.

Inventor： Zijian Zhao ,  Yudan Yin

IPC: A61K38/00 ,  C07K14/00 ,  C07K1/04 ,  C07K1/08 ,  G01N21/64 ,  G01N33/574

Abstract: A peptoid compound, a manufacturing method of a peptoid compound, an oligomer, a pharmaceutical composition, use of the pharmaceutical composition in the preparation of a medicament for detecting or diagnosing a disease related to tyrosine kinase HER2, and a kit for identifying circulating tumor cells are provided, the peptoid compound includes: a cysteine (Cys) subunit, a butanediamine (Nlys) subunit, a 3,4-methylenedioxybenzylamine (Npip) subunit, a 3-aminopropanic acid (Nce) subunit and a 1-naphthylamine (Na) subunit, and both the peptoid compound and the oligomer have a strong ability to bind to HER2 protein on surfaces of circulating tumor cells (CTCs), and a technology of diagnosing breast cancer on the basis of the peptoid compound can realize non-invasive and label-free rapid diagnosis, in addition, the methods for synthesizing the peptoid compound and the oligomer are simple, the preparation efficiency is high, and the production cost is low.

公开(公告)号：US11352390B2

公开(公告)日：2022-06-07

申请号：US16633321

申请日：2019-01-03

Applicant: BEIJING BOE TECHNOLOGY DEVELOPMENT CO., LTD. ,  BOE TECHNOLOGY GROUP CO., LTD.

Inventor： Zijian Zhao

IPC: C07K7/06 ,  A61K38/08 ,  A61K47/34 ,  A61K47/42 ,  C07K1/04

Abstract: A peptoid compound, a nanometer carrier, a pharmaceutical composition, and use of the pharmaceutical composition in manufacture of a medicament for treatment of a disease related to human epidermal growth factor receptor 1 (EGFR). The peptoid compound includes: cysteine (Cys) subunit, 1,4-butanediamine (Nlys) subunit, piperonylamine subunit, β-alanine subunit and 1-naphthylamine subunit. The peptoid compound has high affinity and targeting effect to the EGFR protein, and high selectivity, and meanwhile has high medicament loading efficiency, no toxicity, and high safety.