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公开(公告)号：US12251698B2
公开(公告)日：2025-03-18
申请号：US17489920
申请日：2021-09-30
Inventor： Qiuxu Wei , Wenliang Yao , Yingying Zhao , Le Gu , Bolin Fan , Yongjia Gao
IPC: B01L3/00
Abstract: The disclosure provides a micro-fluidic chip, and belongs to the field of chip technology. The microfluidic chip provided in the present disclosure includes a plurality of microfluidic units, each microfluidic unit includes an operation region and a transition region located on at least one side of the operation region, the transition regions at adjacent side of two adjacent microfluidic units are disposed opposite to each other. Each microfluidic unit includes: a first substrate; a first electrode layer disposed on the first substrate, the first electrode layer including a plurality of first sub-electrodes located in the operation region and at least one second sub-electrode located in the transition region, and the at least one second sub-electrode configured to drive a droplet to move from one of the plurality of microfluidic units to an adjacent microfluidic unit.
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公开(公告)号：US11583855B2
公开(公告)日：2023-02-21
申请号：US17186186
申请日：2021-02-26
Inventor： Hui Liao , Yingying Zhao , Bolin Fan , Wenliang Yao , Nan Zhao , Le Gu , Yongjia Gao
IPC: B01L3/00 , G01N27/22 , G01N33/577
Abstract: The present disclosure discloses a microfluidic structure, a microfluidic chip and a detection method. The microfluidic structure includes: a first base substrate and a second base substrate opposite to each other, an antibody area located between the first base substrate and the second base substrate and storing an enzyme-labeled first antibody, a cleaning area storing cleaning liquid, a signal substrate area storing a signal substrate solution and a detection area with a second antibody and an ion sensitive film fixed thereon, wherein all channel areas from the antibody area, the cleaning area and the signal substrate area to the detection area each have a driving electrode structure driving liquid drops to move; and the detection area has a thin film transistor connected with the ion sensitive film.
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公开(公告)号：US11577246B2
公开(公告)日：2023-02-14
申请号：US16631780
申请日：2019-05-13
Inventor： Le Gu , Peizhi Cai , Fengchun Pang , Yue Geng , Yingying Zhao , Haochen Cui , Yuelei Xiao , Hui Liao , Wenliang Yao , Nan Zhao
Abstract: A microfluidic device and a detection method for the microfluidic device are provided. The microfluidic device includes a driving substrate configured to drive a movement of a droplet; and a position detector configured to detect a position of the droplet on the driving substrate.
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Patent Agency Ranking
公开(公告)号：US11383238B2
公开(公告)日：2022-07-12
申请号：US16626490
申请日：2019-07-26
Inventor： Nan Zhao , Peizhi Cai , Haochen Cui , Yuelei Xiao , Fengchun Pang , Le Gu , Yingying Zhao , Hui Liao , Yue Geng , Wenliang Yao
Abstract: A microfluidic apparatus is provided. The microfluidic apparatus includes an electrochromic layer including a plurality of individually independently addressable regions; a microfluidic layer defining a microfluidic channel for allowing a microfluid to pass therethrough; and a plurality of photodetectors configured to detect light transmit through the microfluid. The electrochromic layer is configured to be switched between a first state in which the plurality of individually independently addressable regions of the electrochromic layer are substantially transmissive, and a second state in which at least a first one of the plurality of individually independently addressable regions of the electrochromic layer in a region corresponding to a position of the microfluid is substantially transmissive, at least a second one of the plurality of individually independently addressable regions of the electrochromic layer outside the region corresponding to the position of the microfluid is substantially non-transmissive.
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公开(公告)号：US11344891B2
公开(公告)日：2022-05-31
申请号：US16768558
申请日：2019-11-13
Inventor： Yingying Zhao , Peizhi Cai , Le Gu , Fengchun Pang , Yue Geng , Yuelei Xiao , Haochen Cui , Nan Zhao , Hui Liao , Wenliang Yao , Chuncheng Che
IPC: B01L3/00
Abstract: The present disclosure provides a microfluidic chip, including: first base substrate and a second base substrate opposite to each other; first electrode and second electrode between the first base substrate and the second base substrate and configured to control droplet to move between the first base substrate and the second base substrate according to voltages applied on the first electrode and the second electrode; light guide component configured to guide light propagating in the first base substrate to the droplet; shading component and detection component, shading component having light transmission regions spaced from each other, light transmission regions being configured to transmit light passing through the droplet to the detection component, wherein detection component is on second base substrate and is configured to obtain property of the droplet according to an intensity of the light passing through droplet and received from the light transmission regions.
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公开(公告)号：US11344889B2
公开(公告)日：2022-05-31
申请号：US16603648
申请日：2019-04-26
Inventor： Haochen Cui , Peizhi Cai , Chuncheng Che , Fengchun Pang , Yingying Zhao , Yue Geng , Le Gu , Nan Zhao , Yuelei Xiao , Hui Liao
Abstract: The embodiments of the present disclosure relate to a microfluidic chip. The microfluidic chip may include a substrate. The substrate may include an electrode layer on a base substrate, a dielectric layer on the electrode layer, and a lyophobic layer on the dielectric layer. The electrode layer may include a plurality of electrode units. Each of the plurality of electrode units may be configured to realize both droplet detection and droplet driving in response to a detection signal and a driving signal respectively.
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公开(公告)号：US20210322973A1
公开(公告)日：2021-10-21
申请号：US16603648
申请日：2019-04-26
Inventor： Haochen Cui , Peizhi Cai , Chuncheng Che , Fengchun Pang , Yingying Zhao , Yue Geng , Le Gu , Nan Zhao , Yuelei Xiao , Hui Liao
Abstract: The embodiments of the present disclosure relate to a microfluidic chip. The microfluidic chip may include a substrate. The substrate may include an electrode layer on a base substrate, a dielectric layer on the electrode layer, and a lyophobic layer on the dielectric layer. The electrode layer may include a plurality of electrode units. Each of the plurality of electrode units may be configured to realize both droplet detection and droplet driving in response to a detection signal and a driving signal respectively.
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公开(公告)号：US20210187507A1
公开(公告)日：2021-06-24
申请号：US16898516
申请日：2020-06-11
Inventor： Hui Liao , Yingying Zhao , Wenliang Yao , Bolin Fan , Nan Zhao , Le Gu , Yongjia Gao
Abstract: The present disclosure discloses a sample preliminary screening chip, a specimen detecting method and a screening device. A data processor may be configured to control a sample solution containing a specimen to be added into a preliminary screening inlet of the sample preliminary screening chip, and control the sample solution in the preliminary screening inlet to enter a channel, successively to flow through a first preliminary screening area and a second preliminary screening area, and to flow out from a preliminary screening outlet so as to store a liquid with the specimen in a first preliminary screening area. In this way, the liquid containing the specimen may be screened preliminarily.
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