公开(公告)号：US12187700B2

公开(公告)日：2025-01-07

申请号：US17593110

申请日：2020-03-12

Applicant: Amgen Inc. ,  Cytokinetics, Inc.

Inventor： Stephanie Azali ,  Mary Chaves ,  Ron C. Kelly ,  Steven M. Mennen ,  Darren L Reid ,  Osama Suleiman ,  Ashraf Wilsily ,  Mark Wright

IPC: C07D401/06

Abstract: Provided herein are free base crystalline forms, crystalline salts, solvates, amorphous free base, and cocrystals of Compound A.

公开(公告)号：US11926592B2

公开(公告)日：2024-03-12

申请号：US17929645

申请日：2022-09-02

Applicant: Amgen Inc.

Inventor： Henry Morrison ,  Sheng Cui ,  Kyle Quasdorf ,  Evelyn Yanez ,  Bin Peter Quan ,  Ron C. Kelly ,  Sebastien Caille ,  Lingyun Xiao ,  David Pearson ,  Jaclyn Raeburn ,  Alisa Golightly

IPC: C07D213/75

CPC classification number: C07D213/75 ,  C07B2200/13

Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.

公开(公告)号：US20220365156A1

公开(公告)日：2022-11-17

申请号：US17766055

申请日：2020-10-02

Applicant: AMGEN INC.

Inventor： Marc A. Caporini ,  Ron C. Kelly ,  Mariana De Maillé

IPC: G01R33/44 ,  G01N24/08

Abstract: Disclosed herein is a method of conducting direct detection 1H solid state NMR (“ssNMR”) on a macromolecule-containing solid state formulation. The method includes conducting a 1H spin-lattice relaxation time (“T1”) experiment on the solid state formulation at various temperatures to generate a T1 value at each temperature, converting the T1 values to 1H spin-lattice relaxation rate (“R1”), and plotting R1 versus temperature to generate a relaxation rate curve for the solid state formulation. The relaxation rate curve can be analyzed to determine the molecular mobility of the macromolecule in the solid state formulation, the degree of aggregation in the solid state formulation, and/or the stability of the solid state formulation.

公开(公告)号：US20200157141A1

公开(公告)日：2020-05-21

申请号：US16494165

申请日：2018-03-14

Applicant: AMGEN INC.

Inventor： Rizwan Sharnez ,  William Trieu ,  Marc A. Caporini ,  Ron C. Kelly ,  Neill Burt ,  Laura Nicholson ,  Twinkle R. Christian

IPC: C07K1/30 ,  A61K39/395 ,  G01N24/08

Abstract: Disclosed herein are methods of preparing a composition comprising crystalline biomolecules, for example, crystalline antibodies. In exemplary embodiments, the method comprises forming a fluidized bed of crystalline biomolecules using, for example, a counter-flow centrifuge to exchange buffer and/or to concentrate the crystalline biomolecules in a solution. Also provided are methods of detecting crystalline biomolecules and/or amorphous biomolecules in a sample.