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公开(公告)号：US20220168280A1
公开(公告)日：2022-06-02
申请号：US17589163
申请日：2022-01-31
Applicant: AMGEN INC.
Inventor： Brian Alan LANMAN , Victor J. CEE , Alexander J. PICKRELL , Anthony B. REED , Kevin C. YANG , David John KOPECKY , Hui-Ling WANG , Patricia LOPEZ , Kate ASHTON , Shon BOOKER , Christopher M. TEGLEY
IPC: A61K31/428 , A61K31/496 , A61K31/519 , A61P35/00 , A61K31/5025 , A61K31/502 , A61K31/517 , C07D275/04 , C07D471/08 , C07D403/04 , C07D401/04 , C07D513/04 , C07D487/04 , C07D417/04 , C07D239/80 , C07D487/10 , C07D471/04
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20240101570A1
公开(公告)日：2024-03-28
申请号：US18255575
申请日：2021-11-22
Applicant: AMGEN INC.
Inventor： Albert AMEGADZIE , Diane Jennifer BEYLKIN , Shon BOOKER , Matthew Paul BOURBEAU , John R. BUTLER , Sanne Ormholt Schroder GLAD , Todd J. KOHN , Brian Alan LANMAN , Kexue LI , Qingyian LIU , Patricia LOPEZ , Francesco MANONI , Primali Vasundera NAVARATNE , Liping H. PETTUS , Rene RAHIMOFF , Nuria A. TAMAYO , Mikkel VESTERGAARD , Hui-Ling WANG , Nicholas Anthony WEIRES
IPC: C07D491/048 , A61K35/00 , C07D401/12 , C07D401/14 , C07D471/04 , C07D471/14 , C07D487/04 , C07D491/147 , C07D495/04 , C07D498/04 , C07D519/00
CPC classification number: C07D491/048 , A61K35/00 , C07D401/12 , C07D401/14 , C07D471/04 , C07D471/14 , C07D487/04 , C07D491/147 , C07D495/04 , C07D498/04 , C07D519/00
Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).
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Patent Agency Ranking
公开(公告)号：US20220395504A1
公开(公告)日：2022-12-15
申请号：US17363878
申请日：2021-06-30
Applicant: Amgen Inc.
Inventor： John Gordon ALLEN , Jennifer Rebecca ALLEN , Ana Elena MINATTI , Qiufen XUE , Ryan Paul WURZ , Christopher M. TEGLEY , Alexander J. PICKRELL , Thomas T. NGUYEN , Vu Van MA , Patricia LOPEZ , Longbin LIU , David John KOPECKY , Michael J. FROHN , Ning CHEN , Jian Jeffrey CHEN , Aaron C. SIEGMUND , Albert AMEGADZIE , Nuria A. TAMAYO , Shon BOOKER , Clifford GOODMAN , Mary WALTON , Nobuko NISHIMURA , Youngsook SHIN , Jonathan D. LOW , Victor J. CEE , Anthony B. REED , Hui-Ling WANG , Brian Alan LANMAN
IPC: A61K31/517 , A61P35/00 , A61K31/4985 , A61K39/395 , C07D403/04 , C07D471/04
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20200207766A1
公开(公告)日：2020-07-02
申请号：US16817109
申请日：2020-03-12
Applicant: Amgen Inc.
Inventor： Brian Alan LANMAN , Shon BOOKER , Clifford GOODMAN , Anthony B. REED , Jonathan D. LOW , Hui-Ling WANG , Ning CHEN , Ana Elena MINATTI , Ryan WURZ , Victor J. CEE
IPC: C07D471/04 , A61P35/00 , A61K31/519
Abstract: Provided herein are methods of using KRAS G12C inhibitors. These methods of using the inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20200069657A1
公开(公告)日：2020-03-05
申请号：US16675121
申请日：2019-11-05
Applicant: AMGEN INC.
Inventor： Brian Alan LANMAN , Victor J. CEE , Alexander J. PICKRELL , Anthony B. REED , Kevin C. YANG , David John KOPECKY , Hui-Ling WANG , Patricia LOPEZ , Kate ASHTON , Shon BOOKER , Christopher M. TEGLEY
IPC: A61K31/428 , A61K31/496 , A61K31/519 , A61P35/00 , A61K31/5025 , A61K31/502 , A61K31/517 , C07D275/04 , C07D471/08 , C07D403/04 , C07D401/04 , C07D513/04 , C07D487/04 , C07D417/04 , C07D239/80 , C07D487/10 , C07D471/04
Abstract: Provided herein are methods of treating cancer with KRAS G12C inhibitors and compositions of the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20190077801A1
公开(公告)日：2019-03-14
申请号：US16125359
申请日：2018-09-07
Applicant: Amgen Inc.
Inventor： Brian Alan LANMAN , Shon BOOKER , Clifford GOODMAN , Anthony B. REED , Jonathan D. LOW , Hui-Ling WANG , Ning CHEN , Ana Elena MINATTI , Ryan WURZ , Victor J. CEE
IPC: C07D471/04 , A61P35/00 , A61K31/519
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20180177767A1
公开(公告)日：2018-06-28
申请号：US15849905
申请日：2017-12-21
Applicant: AMGEN INC.
Inventor： Brian Alan LANMAN , Victor J. CEE , Alexander J. PICKRELL , Anthony B. REED , Kevin C. YANG , David John KOPECKY , Hui-Ling WANG , Patricia LOPEZ , Kate ASHTON , Shon BOOKER , Christopher M. TEGLEY
IPC: A61K31/428 , A61K31/496 , A61K31/519 , A61K31/517 , A61K31/5025 , A61K31/502 , A61P35/00
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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