公开(公告)号：US20230212318A1

公开(公告)日：2023-07-06

申请号：US17727316

申请日：2022-04-22

Applicant: AMGEN INC.

Inventor： Wei Yan ,  Martin J. Pentony ,  Mark L. Michaels ,  Patrick Baeuerle

IPC: C07K16/46 ,  C07K14/725 ,  C07K16/28 ,  C07K16/32

CPC classification number: C07K16/468 ,  C07K14/7051 ,  C07K16/32 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/50

Abstract: Described herein are protease-activatable proteins (PABPs), which, when activated, can mediate cytolysis of target cells by effector cells. Also provided are nucleic acids encoding such PABPs and methods of making and using PABPs.

公开(公告)号：US20230212297A1

公开(公告)日：2023-07-06

申请号：US17697632

申请日：2022-03-17

Applicant: Amgen Inc.

Inventor： Luis G. Borges ,  Patrick Baeuerle ,  Wei Yan ,  Mark L. Michaels

IPC: C07K16/28 ,  C07K16/32 ,  C07K16/00 ,  C07K16/40 ,  C07K16/46 ,  A61K39/00

CPC classification number: C07K16/2863 ,  C07K16/00 ,  C07K16/28 ,  C07K16/32 ,  C07K16/40 ,  C07K16/468 ,  C07K16/2803 ,  C07K16/2809 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/60 ,  C07K2317/64 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2319/00

Abstract: Described herein is a bispecific molecule containing an Fc polypeptide chain and immunoglobulin variable regions. Also provided are pharmaceutical formulations comprising such molecules, nucleic acids encoding such molecules, host cells containing such nucleic acids, methods of making such molecules, and methods of using such molecules.

公开(公告)号：US20190002568A1

公开(公告)日：2019-01-03

申请号：US16032342

申请日：2018-07-11

Applicant: AMGEN INC.

Inventor： Luis G. Borges ,  Patrick Bauerle ,  Wei Yan ,  Mark L. Michaels

IPC: C07K16/28 ,  C07K16/00 ,  C07K16/32 ,  C07K16/40 ,  C07K16/46 ,  A61K39/00

Abstract: Described herein is a bispecific molecule containing an Fc polypeptide chain and immunoglobulin variable regions. Also provided are pharmaceutical formulations comprising such molecules, nucleic acids encoding such molecules, host cells containing such nucleic acids, methods of making such molecules, and methods of using such molecules.

公开(公告)号：US20170247476A1

公开(公告)日：2017-08-31

申请号：US15513011

申请日：2015-09-24

Applicant: AMGEN INC.

Inventor： Wei Yan ,  Martin J. Pentony ,  Mark L. Michaels ,  Patrick Baeuerle

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/32 ,  C07K14/725

CPC classification number: C07K16/468 ,  C07K14/7051 ,  C07K16/2809 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/50

Abstract: Described herein are protease-activatable proteins (PABPs), which, when activated, can mediate cytolysis of target cells by effector cells. Also provided are nucleic acids encoding such PABPs and methods of making and using PABPs.

公开(公告)号：US20160244497A1

公开(公告)日：2016-08-25

申请号：US15007438

申请日：2016-01-27

Applicant: Amgen Inc.

Inventor： Kenneth W. WALKER ,  Colin V. Gegg, JR. ,  Randy I. Hecht ,  Edward J. Belouski ,  Yue-Sheng Li ,  Mark L. Michaels ,  Jing Xu ,  Murielle Marie Ellison

IPC: C07K14/50 ,  A61K47/48

CPC classification number: C07K14/50 ,  A61K38/00 ,  A61K47/60

Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.

Abstract translation: 本发明提供编码FGF21突变体多肽，FGF21突变体多肽，包含FGF21突变体多肽的药物组合物的核酸分子，以及使用此类核酸，多肽或药物组合物治疗代谢紊乱的方法。