公开(公告)号：US20210009577A1

公开(公告)日：2021-01-14

申请号：US17031607

申请日：2020-09-24

Applicant: Amgen Inc.

Inventor： Brian Alan LANMAN ,  Jian CHEN ,  Anthony B. REED ,  Victor J. CEE ,  Longbin LIU ,  David John KOPECKY ,  Patricia LOPEZ ,  Ryan Paul WURZ ,  Thomas T. NGUYEN ,  Shon BOOKER ,  Nobuko NISHIMURA ,  Youngsook SHIN ,  Nuria A. TAMAYO ,  John Gordon ALLEN ,  Jennifer Rebecca ALLEN

IPC: C07D417/04 ,  A61K38/07 ,  C07D487/08 ,  C07D417/12 ,  C07D513/04 ,  C07D487/10 ,  C07D487/04 ,  C07D471/04 ,  C07D401/04 ,  C07D239/80 ,  C07D401/14 ,  C07D237/34 ,  C07D403/04 ,  A61K31/496 ,  A61K31/416 ,  A61K31/55 ,  A61K31/454 ,  A61K31/517 ,  A61K31/519 ,  A61K31/502 ,  A61K31/5025 ,  A61P35/00 ,  A61K31/7068 ,  C07D275/04 ,  C07D475/00

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

公开(公告)号：US20180334454A1

公开(公告)日：2018-11-22

申请号：US15984855

申请日：2018-05-21

Applicant: Amgen Inc.

Inventor： Brian Alan LANMAN ,  Jian CHEN ,  Anthony B. REED ,  Victor J. CEE ,  Longbin LIU ,  David John KOPECKY ,  Patricia LOPEZ ,  Ryan Paul WURZ ,  Thomas T. NGUYEN ,  Shon BOOKER ,  Nobuko NISHIMURA ,  Youngsook SHIN ,  Nuria A. TAMAYO ,  John Gordon ALLEN ,  Jennifer Rebecca ALLEN

IPC: C07D417/04 ,  C07D275/04 ,  C07D487/08 ,  C07D417/12 ,  C07D513/04 ,  C07D487/10 ,  C07D487/04 ,  C07D471/04 ,  C07D401/04 ,  C07D239/80 ,  C07D401/14 ,  C07D237/34 ,  C07D403/04 ,  A61K31/496 ,  A61K31/416 ,  A61K31/55 ,  A61K31/454 ,  A61K31/517 ,  A61K31/519 ,  A61K31/502 ,  A61K31/5025 ,  A61P35/00 ,  A61K31/7068 ,  A61K38/07

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.