公开(公告)号：US20250084160A1

公开(公告)日：2025-03-13

申请号：US18610640

申请日：2024-03-20

Applicant: Amgen Inc.

Inventor： Shouhua Xiao ,  Zheng Pan ,  Dineli Wickramasinghe ,  M. Shawn Jeffries ,  Chadwick Terence King ,  Brian Mingtung Chan

IPC: C07K16/28 ,  A61K39/00 ,  A61K47/68 ,  C07K16/30

Abstract: The present disclosure provides a human antibody or antigen binding fragment thereof or an antibody construct comprising a human binding domain or antigen binding fragment thereof capable of binding to human CDH19 on the surface of a target cell. The disclosure relates to a nucleic acid sequence encoding the antibody or antigen binding fragment thereof contained in the antibody construct, a vector comprising the nucleic acid sequence and a host cell transformed or transfected with the vector. Furthermore, the disclosure relates to a process for the production of the antibody construct of the disclosure, a medical use or a method of treatment using the antibody construct and a kit comprising the antibody or antigen binding fragment thereof or the antibody construct.

公开(公告)号：US20200071405A1

公开(公告)日：2020-03-05

申请号：US16570129

申请日：2019-09-13

Applicant: AMGEN RESEARCH (MUNICH) GMBH ,  AMGEN INC.

Inventor： Shouhua Xiao ,  Zheng Pan ,  Dineli Wickramasinghe ,  M. Shawn Jeffries ,  Chadwick Terence King ,  Brian Mingtung Chan ,  Peter Kufer ,  Ralf Lutterbüse ,  Tobias Raum ,  Patrick Hoffmann ,  Doris Rau ,  Roman Kischel ,  Bryan Lemon ,  Holger Wesche

IPC: C07K16/28 ,  C07K16/30 ,  A61K47/60 ,  C07K16/46

Abstract: The present invention provides to a antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention relates to a nucleic acid sequence encoding the antibody construct, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

公开(公告)号：US20190016805A1

公开(公告)日：2019-01-17

申请号：US16040927

申请日：2018-07-20

Applicant: AMGEN RESEARCH (MUNICH) GMBH ,  AMGEN INC.

Inventor： Shouhua Xiao ,  Zheng Pan ,  Dineli Wickramasinghe ,  M. Shawn Jeffries ,  Chadwick Terence King ,  Brian Mingtung Chan ,  Peter Kufer ,  Ralf Lutterbüse ,  Tobias Raum ,  Patrick Hoffmann ,  Doris Rau ,  Roman Kischel ,  Bryan Lemon ,  Holger Wesche

IPC: C07K16/28 ,  A61K47/60 ,  C07K16/30 ,  C07K16/46 ,  A61K39/00

Abstract: The present invention provides to a antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention relates to a nucleic acid sequence encoding the antibody construct, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

公开(公告)号：US20180208654A1

公开(公告)日：2018-07-26

申请号：US15878047

申请日：2018-01-23

Applicant: AMGEN INC.

Inventor： Shouhua Xiao ,  Zheng Pan ,  Dineli Wickramasinghe ,  M. Shawn Jeffries ,  Chadwick Terence King ,  Brian Mingtung Chan

IPC: C07K16/28 ,  A61K47/68 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6865 ,  A61K2039/505 ,  C07K16/3053 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/92

Abstract: The present disclosure provides a human antibody or antigen binding fragment thereof or an antibody construct comprising a human binding domain or antigen binding fragment thereof capable of binding to human CDH19 on the surface of a target cell. The disclosure relates to a nucleic acid sequence encoding the antibody or antigen binding fragment thereof contained in the antibody construct, a vector comprising the nucleic acid sequence and a host cell transformed or transfected with the vector. Furthermore, the disclosure relates to a process for the production of the antibody construct of the disclosure, a medical use or a method of treatment using the antibody construct and a kit comprising the antibody or antigen binding fragment thereof or the antibody construct.

公开(公告)号：US20150368343A1

公开(公告)日：2015-12-24

申请号：US14761839

申请日：2014-01-27

Applicant: AMGEN RESEARCH (MUNICH) GMBH ,  AMGEN INC.

Inventor： Shouhua Xiao ,  Zheng Pan ,  Dineli Wickramasinghe ,  M. Shawn Jeffries ,  Chadwick Terence King ,  Brian Mingtung Chan ,  Peter Kufer ,  Ralf Lutterbuese ,  Tobias Raum ,  Patrick Hoffmann ,  Doris Rau ,  Roman Kischel ,  Bryan Lemon ,  Holger Wesche

IPC: C07K16/28

CPC classification number: C07K16/2809 ,  A61K47/60 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2896 ,  C07K16/3053 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/00

Abstract: The present invention provides to a antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention relates to a nucleic acid sequence encoding the antibody construct, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

Abstract translation: 本发明提供了一种抗体构建物，其包含能够结合靶细胞表面上的人CDH19的第一人结合结构域和能够结合T细胞表面上的人CD3的第二结构域。 此外，本发明涉及编码抗体构建体的核酸序列，包含所述核酸序列的载体和用所述载体转化或转染的宿主细胞。 此外，本发明涉及制备本发明的抗体构建体的方法，所述抗体构建体的医学用途和包含所述抗体构建体的试剂盒。