公开(公告)号：US11694886B2

公开(公告)日：2023-07-04

申请号：US17289074

申请日：2019-10-30

申请人： NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY ,  SHIMADZU CORPORATION

发明人： Yuka Fujito ,  Takanari Hattori ,  Tomohisa Hasunuma

IPC分类号： H01J49/00 ,  H01J49/04 ,  G01N30/72 ,  H01J49/16 ,  G01N30/02

CPC分类号： H01J49/0445 ,  G01N30/7266 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/165 ,  G01N2030/027

摘要： An analysis method includes: performing liquid chromatography using a mobile phase including an adsorption prevention agent for preventing adsorption of a sample including a compound having a phosphate group to metal; and performing mass spectrometry on an eluate of the liquid chromatography. The adsorption prevention agent includes an oxalic acid or a salt of the oxalic acid.

公开(公告)号：US20220289579A1

公开(公告)日：2022-09-15

申请号：US17639751

申请日：2020-09-02

申请人： NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY ,  MITSUBISHI GAS CHEMICAL COMPANY, INC.

发明人： Akihiko TSUDA

IPC分类号： C01B32/80

摘要： The objective of the present invention is to provide a method for producing a halogenated carbonyl safely and efficiently. The method for producing a halogenated carbonyl according to the present invention is characterized in comprising the step of applying ultrasound to a composition containing a C1-4 halogenated hydrocarbon having one or more halogeno groups selected from the group consisting of chloro, bromo and iodo in the presence of oxygen to decompose the C1-4 halogenated hydrocarbon.

公开(公告)号：US20220259518A1

公开(公告)日：2022-08-18

申请号：US17625598

申请日：2021-07-11

申请人： NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE ,  NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

发明人： Takahiko HARIYAMA ,  Mamiko OZAKI

IPC分类号： C11B9/00 ,  A61K8/31 ,  A61K8/35 ,  A61Q13/00 ,  C09D11/03

摘要： The present invention provides an odorant composition having good palatability allowing peoples to feel comfortable using a small number of chemical compounds. An odorant composition according to an embodiment of the present invention consists of: when the total mass of ingredients contained in the odorant composition is 100.0% by mass, 40.0% by mass or more and 97.5% by mass or less of an ingredient (A) composed of aldehydes; 1.0% by mass or more and 20.0% by mass or less of an ingredient (B) composed of a ketone(s); and the balance being an ingredient (C) composed of a chemical compound(s) other than the ingredient (A) and the ingredient (B). The aldehydes of the ingredient (A) are: an essential ingredient (A1) composed of nonanal; and an optional ingredient (A2) selected from the group consisting of decanal, heptanal, octanal, benzaldehyde, undecanal, hexanal, and combinations thereof. The ketone(s) of the ingredient (B) is selected from the group consisting of 6-methyl-5-hepten-2-one, cyclohexanone, 1-phenylethanone, 2-decanone, 2-undecanone, and combinations thereof. The chemical compound(s) of the ingredient (C) is selected from the group consisting of limonene, 1,8-cineole, menthol, 1-octanol, 3-hexyn-1-ol, 2-nonen-1-ol, dodecane, hexanoic acid, octanoic acid, nonanoic acid, 2(5H)-furanone, p-cymene, sotolon, and combinations thereof.

公开(公告)号：US20220221378A1

公开(公告)日：2022-07-14

申请号：US17259602

申请日：2019-07-10

申请人： NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY ,  SHIMADZU CORPORATION

发明人： Aya TORAI ,  Yoshihiro MATSUMOTO ,  Tomohisa HASUNUMA

IPC分类号： G01N1/20 ,  G01N30/72 ,  G01N30/38

摘要： A sampling apparatus 1 samples a culture medium in a bioreactor 11. A pump 21 circulates the culture medium in the bioreactor 11 via a flow path 41 by leading out the culture medium from the bioreactor 11 into the flow path 41 and introducing the culture medium from the flow path 41 into the bioreactor 11. A valve 22 is provided in the middle of the flow path 41, and switches a flow path such that the culture medium circulated in the flow path 41 flows out to a branch flow path 42 to be sampled.

公开(公告)号：US11230709B2

公开(公告)日：2022-01-25

申请号：US16467224

申请日：2017-12-25

申请人： DAIICHI SANKYO COMPANY, LIMITED ,  NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

发明人： Kazumoto Iijima ,  Kandai Nozu ,  Akemi Shono ,  Makoto Koizumi ,  Yoshiyuki Onishi ,  Kiyosumi Takaishi ,  Tomomi Adachi

IPC分类号： C12N15/113 ,  A61K31/713 ,  A61P13/12

摘要： The present invention aims at establishing a molecular therapy for Alport syndrome. The present invention provides an oligonucleotide of 15-30 bp comprising a nucleotide sequence complementary to the cDNA of COL4A5 gene, wherein the oligonucleotide is capable of inducing skipping of an exon which has a truncating mutation found in COL4A5 gene in Alport syndrome patients and whose nucleotide number is a multiple of 3, a pharmaceutically acceptable salt thereof, or a solvate thereof. Also provided is a pharmaceutical drug comprising the above oligonucleotide, a pharmaceutically acceptable salt thereof, or a solvate thereof (therapeutic drug for Alport syndrome).

公开(公告)号：US11220693B2

公开(公告)日：2022-01-11

申请号：US15779120

申请日：2016-11-25

申请人： NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

发明人： Keiji Nishida ,  Zenpei Shimatani ,  Akihiko Kondo

IPC分类号： C12N15/82 ,  C12N9/10 ,  C12N9/78 ,  C12N15/09 ,  C12N9/16 ,  C12N9/22

摘要： The present invention provides a method of modifying a targeted site of a double stranded DNA of a monocot cell, comprising a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in the given double stranded DNA and a nucleic acid base converting enzyme are bonded, with said double stranded DNA, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into said targeted site, without cleaving at least one strand of said double stranded DNA in the targeted site, wherein the double stranded DNA is contacted with the complex by introducing a nucleic acid encoding the complex into the monocot cell. Furthermore, also provided is a complex used for the method, wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a double stranded DNA of a monocot cell and a nucleic acid base converting enzyme are bonded.

公开(公告)号：US20210388159A1

公开(公告)日：2021-12-16

申请号：US17292194

申请日：2019-11-14

申请人： NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY ,  MITSUBISHI GAS CHEMICAL COMPANY, INC.

发明人： Akihiko TSUDA

IPC分类号： C08G64/38 ,  C08G64/06 ,  C08G64/16 ,  C08G64/02

摘要： The objective of the present invention is to provide a method for producing a polycarbonate safely and efficiently. A method for producing a polycarbonate is characterized in comprising the step of irradiating a light to a composition comprising a C1-4 halogenated hydrocarbon, the specific diol compound and the specific base in the presence of oxygen.

公开(公告)号：US20210388139A1

公开(公告)日：2021-12-16

申请号：US17285829

申请日：2019-09-04

申请人： National University Corporation Kobe University ,  Murata Manufacturing Co., Ltd.

发明人： Toshifumi Takeuchi ,  Hirobumi Sunayama ,  Eri Takano

IPC分类号： C08F222/38 ,  C07K17/08 ,  C08F220/56 ,  C08F220/06 ,  C08F8/00

摘要： The present invention provides a polymer replica of a target molecule, the polymer replica being capable of accurately inheriting surface information possessed by the target molecule in a molecular imprinting technique. A polymer replica of a target substance, the target substance having multiple types of binding groups including at least a binding group BG1 and a binding group BG2 on the surface, wherein: the polymer replica is configured from a second molecularly imprinted polymer having, as a template, a first molecularly imprinted polymer having the target substance as a template; the polymer replica has on the surface thereof at least a binding group bg1 at a position corresponding to the position of binding group BG1 and a binding group bg2 at a position corresponding to the position of the binding group BG2 on the surface of the target substance; and the polymer replica of the target substance can be used as a template during synthesis of a molecularly imprinted polymer having a specific recognition site for the target substance because the polymer replica accurately inherits the surface information possessed by the target molecule.

公开(公告)号：US11167259B2

公开(公告)日：2021-11-09

申请号：US16605635

申请日：2018-04-27

申请人： NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY ,  AGC Inc.

发明人： Akihiko Tsuda

IPC分类号： C08F2/46 ,  C08F2/50 ,  C08G61/04 ,  B01J19/12 ,  C07C69/96 ,  C08G64/02 ,  C08G64/10 ,  C08G64/38 ,  C08G71/02 ,  C08G71/04

摘要： The objective of the present invention is to provide a method for producing a fluorinated carbonate derivative in a safe and efficient manner. The method for producing a fluorinated carbonate derivative according to the present invention is characterized in comprising irradiating light on a composition containing a C1-4 halogenated hydrocarbon having one or more kinds of halogen atoms selected from the group consisting of a chlorine atom, a bromine atom and an iodine atom, a fluorine-containing compound having a nucleophilic functional group and a base in the presence of oxygen.

公开(公告)号：US20210292698A1

公开(公告)日：2021-09-23

申请号：US17259612

申请日：2019-07-10

申请人： NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY ,  SHIMADZU CORPORATION

发明人： Aya TORAI ,  Yoshihiro MATSUMOTO ,  Tomohisa HASUNUMA

IPC分类号： C12M1/06

摘要： A stirring device 11 includes a stirring mechanism 7 and a control unit 15. The stirring mechanism 7 includes a motor 74 and a pedestal portion 77. In the stirring device 11, the motor 74 repeats forward rotation and reverse rotation alternately under the control of the control unit 15. Then, the pedestal portion 77 repeats turning in one direction and turning in the other direction alternately. As a result, the test tube S repeats the movement in one direction and the movement in the other direction alternately, and the vortex rotating in one direction and the vortex rotating in the other direction are alternately generated in the mixed solution in the test tube S. Then, the mixed solution in the test tube S is stirred to be rotated, and is stirred to be moved in the vertical direction. Therefore, the mixed solution in the test tube S can be efficiently stirred. As a result, the time required for stirring the mixed solution in the test tube S can be shortened.