公开(公告)号：US5663166A

公开(公告)日：1997-09-02

申请号：US452056

申请日：1995-05-26

Applicant: Brent Blackburn ,  Peter Barker ,  Thomas Gadek ,  Robert McDowell ,  Lawrence McGee ,  Todd Somers ,  Rob Webb ,  Kirk Robarge

Inventor： Brent Blackburn ,  Peter Barker ,  Thomas Gadek ,  Robert McDowell ,  Lawrence McGee ,  Todd Somers ,  Rob Webb ,  Kirk Robarge

IPC: C07D223/16 ,  C07D243/10 ,  C07D243/14 ,  C07D267/14 ,  A61K31/55 ,  C07D487/04

CPC classification number: C07D223/16 ,  C07D243/10 ,  C07D243/14 ,  C07D267/14

Abstract: A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPII.sub.b III.sub.a receptor and is provided in therapeutic compositions for the treatment of diseases for which blocking platelet aggregation is indicated. These nonpeptidyl inhibitors are provided in combination with thrombolytics and anticoagulants.