公开(公告)号：US07844445B2

公开(公告)日：2010-11-30

申请号：US11801240

申请日：2007-05-08

申请人： Jeffrey Brunet ,  Ian Collins ,  Yousuf Chowdhary ,  Eric Li

发明人： Jeffrey Brunet ,  Ian Collins ,  Yousuf Chowdhary ,  Eric Li

IPC分类号： G06F9/455 ,  G06F3/00 ,  G06F5/00 ,  G06F13/12

CPC分类号： G06F11/1456 ,  G06F11/1451 ,  G06F11/1458 ,  G06F11/1461 ,  G07F17/0014

摘要： A software application is provided for a user to select a backed up data file and specify a task to be performed by an online service provider on the selected file. The application automatically connects to the online service provider and uploads the selected file for the online service provider to perform the task. Tasks that can be performed include printing, sharing, viewing, playing and archiving the selected file. Task preferences, user settings and user information can also be specified by the user and uploaded to the online service provider. Automatic connection to the online service provider can be via default setting, selected file type, or specified task. Alternatively, the user can designate which service provider is to perform the task. Payment for the task can be accomplished via bundled credits or by other payment mechanisms.

摘要翻译： 提供软件应用程序供用户选择备份的数据文件，并指定由所选文件上的在线服务提供商执行的任务。 应用程序自动连接到在线服务提供商，并上传所选文件以供在线服务提供商执行任务。 可执行的任务包括打印，共享，查看，播放和归档所选文件。 任务首选项，用户设置和用户信息也可以由用户指定并上传到在线服务提供商。 可以通过默认设置，选定的文件类型或指定的任务自动连接到在线服务提供商。 或者，用户可以指定哪个服务提供者要执行任务。 任务的付款可以通过捆绑信用或其他支付机制来完成。

公开(公告)号：US20100273837A1

公开(公告)日：2010-10-28

申请号：US12678767

申请日：2008-09-22

申请人： David John Haydon ,  Ian Collins ,  Lloyd George Czaplewski

发明人： David John Haydon ,  Ian Collins ,  Lloyd George Czaplewski

IPC分类号： A61K31/433 ,  C07D285/08 ,  A61P31/04 ,  A01N43/836 ,  A01P1/00

CPC分类号： C07D285/08

摘要： Compounds of formula (IA) or (IB) have antibacterial activity: wherein W is ═CH— or ═N—; Ri and R2 are independently selected from hydrogen, fluoro and chloro, provided that Ri and R2 are not each hydrogen when W is ═CH—; n is 0 or 1; X is —O—, —S—, or —CH2—; and Q is (i) a phenyl radical, a naphthyl radical, a monocyclic carbocyclic or heteroaryl radical having 3 to 6 ring atoms, or a bicyclic heteroaryl radical having 5 to 10 ring atoms, any of which radicals being optionally substituted; or (ii) an optionally substituted C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl radical, which may optionally be interrupted by —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, —N(CH2CH3)—, —C—K═Oh or —C(═O)—O—.

摘要翻译： 式（IA）或（IB）的化合物具有抗菌活性：其中W是= CH-或= N-; R 1和R 2独立地选自氢，氟和氯，条件是当W是= CH-时，R 1和R 2不是氢。 n为0或1; X是-O - ， - S-或-CH 2 - ; Q为（i）具有3〜6个环原子的苯基，萘基，单环碳环或杂芳基，或环原子数为5〜10的双环杂芳基，其中任意一个为任选被取代的基团; 或（ⅱ）任选被-O - ， - S - ， - S（O） - ， - S（O 2））间隔的任选取代的C 1 -C 6烷基，C 2 -C 6烯基或C 2 -C 6炔基， - ， - NH - ， - N（CH 3） - ， - N（CH 2 CH 3） - ， - C-K = Oh或-C（= O）-O-。

公开(公告)号：US07822595B2

公开(公告)日：2010-10-26

申请号：US11704802

申请日：2007-02-08

申请人： Jeffrey Brunet ,  Ian Collins ,  Yousuf Chowdhary ,  Eric Li

发明人： Jeffrey Brunet ,  Ian Collins ,  Yousuf Chowdhary ,  Eric Li

IPC分类号： G06F9/455

CPC分类号： G06F11/1451 ,  G06F11/1456 ,  G06F11/1458 ,  G06F11/1461

摘要： A backup system is provided that includes a backup application configured to automatically execute upon connection of the backup system to a data source. The backup application is configured to selectively back up data from the data source to itself or to networked storage, for example. As part of selectively backing up data, the backup application is further configured to selectively extract embedded data files, such as attachments, from internal files of e-mail programs. Between backups, the backup application can selectively extract newly received embedded data files to a folder. During a subsequent backup, the contents of the folder can be copied from the data source.

摘要翻译： 提供了一种备份系统，其包括被配置为在备份系统连接到数据源时自动执行的备份应用程序。 备份应用被配置为例如选择性地将数据从数据源备份到其自身或网络存储。 作为选择性备份数据的一部分，备份应用程序进一步配置为从电子邮件程序的内部文件中有选择地提取嵌入式数据文件，如附件。 在备份之间，备份应用程序可以有选择地将新接收的嵌入式数据文件提取到文件夹中。 在后续备份期间，可以从数据源复制文件夹的内容。

公开(公告)号：US20100130464A1

公开(公告)日：2010-05-27

申请号：US11993831

申请日：2006-06-21

申请人： Thomas Glanmor Davies ,  Robert George Boyle ,  Ian Collins ,  Michelle Dawn Garrett

发明人： Thomas Glanmor Davies ,  Robert George Boyle ,  Ian Collins ,  Michelle Dawn Garrett

IPC分类号： A61K31/415 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/397 ,  A61P35/00

CPC分类号： C07D401/14 ,  C07D231/12 ,  C07D401/04 ,  C07D401/10 ,  C07D403/10 ,  C07D403/12 ,  C07D413/10

摘要： The invention provides compounds of the formula (I) having ROCK kinase and/or protein kinase p70S6K inhibiting activity: wherein A is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length of 5 atoms extending between R1 and NR2R3 and a maximum chain length of 4 atoms extending between E and NR2R3, wherein one of the carbon atoms in the linker group may optionally be replaced by an oxygen or nitrogen atom; and wherein the carbon atoms of the linker group A may optionally bear one or more substituents selected from oxo, fluorine and hydroxy, provided that the hydroxy group when present is not located at a carbon atom a with respect to the NR2R3 group and provided that the oxo group when present is located at a carbon atom α with respect to the NR2R3 group; E is a monocyclic or bicyclic carbocyclic or heterocyclic group; R1 is an aryl or heteroaryl group; and R2, R3, R4 and R5 are as defined in the claims.

摘要翻译： 本发明提供具有ROCK激酶和/或蛋白激酶p70S6K抑制活性的式（I）化合物：其中A是含有1至7个碳原子的饱和烃连接基团，连接基团的最大链长度为5个原子延伸 在R 1和NR 2 R 3之间并且在E和NR 2 R 3之间延伸的4个原子的最大链长度，其中连接基团中的一个碳原子可以任选地被氧或氮原子替代; 并且其中连接基团A的碳原子可以任选地具有一个或多个选自氧代，氟和羟基的取代基，条件是当存在的羟基不相对于NR 2 R 3基团位于碳原子a时， 存在时的氧代基相对于NR2R3基团位于碳原子α; E是单环或双环碳环或杂环基; R1是芳基或杂芳基; 并且R 2，R 3，R 4和R 5如权利要求中所定义。

公开(公告)号：US20090124610A1

公开(公告)日：2009-05-14

申请号：US12298384

申请日：2007-04-25

申请人： Gordon Saxty ,  Marinus Leendert Verdonk ,  John Caldwell ,  Ian Collins ,  Kwai-Ming Cheung ,  Tatiana Faria Da Fonseca McHardy

发明人： Gordon Saxty ,  Marinus Leendert Verdonk ,  John Caldwell ,  Ian Collins ,  Kwai-Ming Cheung ,  Tatiana Faria Da Fonseca McHardy

IPC分类号： A61K31/5383 ,  C07D495/04 ,  A61K31/519 ,  A61K31/496 ,  C07D211/56 ,  A61K31/44 ,  C07D409/14 ,  A61K31/445 ,  C07D211/06 ,  C07D401/14 ,  A61K31/437 ,  C07D413/14

CPC分类号： C07D471/04 ,  C07D495/04

摘要： Compounds of the formula (I), and salts, solvates, tautomers and N-oxide thereof, wherein TG is selected from groups (1) and (2): wherein the asterisk (*) represents the point of attachment of the group E to the group X; R1a is an optionally substituted aryl or heteroaryl group; R1b is hydrogen or a group R1a; X is an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 are heteroatoms selected from O, N and S; and A, E, R2, R3, R4, Q1 and Q2 are as defined in the claims; provided that when E is aryl or heteroaryl, then Q2 is other than a bond; and further provided that the moiety (a) is other than a group (BG1) or (BG2); wherein (BG1) and (BG2) are each optionally substituted; T is N or CRZ; J1-J2 is selected from N═C(RZ), (RZ)C═N, (RZ)N—C(O), (RZ)2C—C(O), N═N and (RZ)C═C(R6); J4-J3 is a group N═C(RZ) or a group (RZ)N—CO; and RZ is hydrogen or a substituent. The compounds of the formula (I) have PKA and PKB kinase inhibiting activity and are useful in the treatment of cancers.

摘要翻译： 式（I）的化合物及其盐，溶剂合物，互变异构体和N-氧化物，其中TG选自（1）和（2）组：其中星号（*）表示基团E与 组X; R 1a是任选取代的芳基或杂芳基; R1b是氢或R1a基团; X是任选取代的具有8至12个环成员的双环杂环基，其中多至5个是选自O，N和S的杂原子; A，E，R2，R3，R4，Q1和Q2如权利要求中所定义; 条件是当E是芳基或杂芳基时，则Q2不是键; 并且进一步规定部分（a）不是基团（BG1）或（BG2）; 其中（BG1）和（BG2）各自任选被取代; T为N或CRZ; J-J2选自N-C（RZ），（RZ）C-N，（RZ）N-C（O），（RZ）2C-C（O），N-N和（RZ）C-C（R6） J4-J3为基团N-C（RZ）或基团（RZ）N-CO; RZ是氢或取代基。 式（I）化合物具有PKA和PKB激酶抑制活性，可用于治疗癌症。

公开(公告)号：US20070246426A1

公开(公告)日：2007-10-25

申请号：US11632994

申请日：2005-06-30

申请人： Ian Collins

发明人： Ian Collins

IPC分类号： B01D61/02

CPC分类号： C09K8/528 ,  B01D61/002 ,  B01D61/005 ,  B01D2311/04 ,  B01D2311/2626 ,  B01D2311/2649 ,  B01D2311/2657 ,  B01D2317/04 ,  C09K8/58 ,  E21B37/06 ,  E21B43/20 ,  Y02A20/131

摘要： A method of recovering hydrocarbons from a porous subterranean hydrocarbon-bearing formation comprising: (a) feeding a first stream comprising a high salinity water to a first side of a semipermeable membrane of at least one forward osmosis unit of a desalination plant and feeding a second stream comprising an aqueous solution of a removable solute to a second side of the semipermeable membrane wherein the solute concentration of the aqueous solution of the removable solute is sufficiently greater than the solute concentration of the high salinity water that water passes through the semipermeable membrane from the high salinity water into the aqueous solution of the removable solute to form a diluted aqueous solution of the removable solute; (b) withdrawing a third stream comprising a concentrated brine and a fourth stream comprising a diluted aqueous solution of the removable solute from the first and second sides respectively of the semipermeable membrane of the forward osmosis unit; (c) substantially separating the removable solute from the fourth stream comprising the diluted aqueous solution of the removable solute to form a low salinity water stream having a total dissolved solids content of less than 5000 ppm; (d) if necessary, increasing the salinity of the low salinity water stream to a total dissolved solids content of at least 200 @ @ m; (e) introducing the treated low salinity water into the hydrocarbon-bearing formation via an injection well; (f) displacing the hydrocarbons with the treated low salinity water towards an associated production well; and (g) recovering hydrocarbons from the formation via the production well.

摘要翻译： 一种从多孔地下含烃地层回收烃的方法，包括：（a）将包含高盐度水的第一物流供给至少一个脱盐设备的至少一个正渗透单元的半透膜的第一侧，并将第二物流 包含可去除溶质的水溶液到半透膜的第二侧的流，其中可除去溶质的水溶液的溶质浓度足够大于水从半透膜中通过半渗透膜的高盐度水的溶质浓度 高盐度水进入可除去溶质的水溶液中形成可去除溶质的稀释水溶液; （b）从正向渗透单元的半透膜的第一侧和第二侧排出包括浓缩盐水和第四料流的第三料流，所述第四料流包含可除去溶质的稀释水溶液; （c）将可移除溶质与包含可除去溶质的稀释水溶液的第四料流基本分离，以形成总溶解固体含量小于5000ppm的低盐度水流; （d）如有必要，将低盐度水流的盐度提高至至少200 @ m的总溶解固体含量; （e）通过注射井将经处理的低盐度水引入含烃地层; （f）将处理过的低盐度水代替烃与相关的生产井; 和（g）通过生产井从地层回收碳氢化合物。

公开(公告)号：US20070162271A1

公开(公告)日：2007-07-12

申请号：US11715008

申请日：2007-03-06

申请人： Jeffrey Brunet ,  Ian Collins ,  Yousuf Chowdhary ,  Eric Li

发明人： Jeffrey Brunet ,  Ian Collins ,  Yousuf Chowdhary ,  Eric Li

IPC分类号： G06F9/455

CPC分类号： G06F11/1451 ,  G06F11/1456 ,  G06F11/1461

摘要： A backup system includes a backup application configured to automatically execute upon connection of the backup system to a data source. The backup application is further configured to selectively back up data files from the data source, either to itself or to another location. The backup application is also configured to provide a GUI through which a user can select data files to be printed from amongst the backed up data files. Selected data files can be printed from the data source by an online service or by a local or networked printer. Additionally, the backup system can be directly connected to a kiosk or printer to print the selected data files.

摘要翻译： 备份系统包括被配置为在将备份系统连接到数据源时自动执行的备份应用程序。 备份应用还被配置为选择性地将数据文件从数据源备份到其自身或另一位置。 备份应用程序还被配置为提供GUI，用户可以通过该GUI从备份的数据文件中选择要打印的数据文件。 可以通过在线服务或本地或网络打印机从数据源打印选定的数据文件。 此外，备份系统可以直接连接到报亭或打印机来打印选定的数据文件。

公开(公告)号：US20070143097A1

公开(公告)日：2007-06-21

申请号：US11704802

申请日：2007-02-08

申请人： Jeffrey Brunet ,  Ian Collins ,  Yousuf Chowdhary ,  Eric Li

发明人： Jeffrey Brunet ,  Ian Collins ,  Yousuf Chowdhary ,  Eric Li

IPC分类号： G06F9/455

CPC分类号： G06F11/1451 ,  G06F11/1456 ,  G06F11/1458 ,  G06F11/1461

摘要： A backup system is provided that includes a backup application configured to automatically execute upon connection of the backup system to a data source. The backup application is configured to selectively back up data from the data source to itself or to networked storage, for example. As part of selectively backing up data, the backup application is further configured to selectively extract embedded data files, such as attachments, from internal files of e-mail programs. Between backups, the backup application can selectively extract newly received embedded data files to a folder. During a subsequent backup, the contents of the folder can be copied from the data source.

摘要翻译： 提供了一种备份系统，其包括被配置为在备份系统连接到数据源时自动执行的备份应用程序。 备份应用被配置为例如选择性地将数据从数据源备份到其自身或网络存储。 作为选择性备份数据的一部分，备份应用程序进一步配置为从电子邮件程序的内部文件中有选择地提取嵌入式数据文件，如附件。 在备份之间，备份应用程序可以有选择地将新接收的嵌入式数据文件提取到文件夹中。 在后续备份期间，可以从数据源复制文件夹的内容。

公开(公告)号：US20070143096A1

公开(公告)日：2007-06-21

申请号：US11605770

申请日：2006-11-28

申请人： Jeffrey Brunet ,  Ian Collins ,  Yousuf Chowdhary ,  Eric Li ,  Alex Lemelev

发明人： Jeffrey Brunet ,  Ian Collins ,  Yousuf Chowdhary ,  Eric Li ,  Alex Lemelev

IPC分类号： G06F9/455

CPC分类号： G06F3/0605 ,  G06F3/0632 ,  G06F3/065 ,  G06F3/0676 ,  G06F3/0677 ,  G06F3/0679 ,  G06F11/1451 ,  G06F11/1456 ,  G06F11/1461

摘要： A data backup system is provided for backing up data files from a data source and for securing those data files against accidental modification or deletion. The system comprises storage and a data protection component that includes an application programming interface defining a command set. The system can also comprise a backup application that is configured to use the commands of the command set. The data protection component allows applications that use the commands of the command set, such as the backup application, to access the storage of the system. The data protection component prevents operating systems and applications that do not use the commands of the command set from accessing the storage. The data protection function of the data protection component can optionally be disabled to allow open access to the storage.

摘要翻译： 提供数据备份系统，用于从数据源备份数据文件，并保护这些数据文件免受意外修改或删除。 该系统包括存储和数据保护组件，其包括定义命令集的应用程序编程接口。 系统还可以包括配置为使用命令集的命令的备份应用程序。 数据保护组件允许使用命令集的命令（如备份应用程序）访问系统存储的应用程序。 数据保护组件防止不使用命令集命令的操作系统和应用程序访问存储。 可以选择禁用数据保护组件的数据保护功能，以允许对存储器的打开访问。

公开(公告)号：US20070083354A1

公开(公告)日：2007-04-12

申请号：US11492380

申请日：2006-07-24

申请人： Ian Collins ,  Eric Li ,  Yousuf Chowdhary ,  Jeffrey Brunet

发明人： Ian Collins ,  Eric Li ,  Yousuf Chowdhary ,  Jeffrey Brunet

IPC分类号： G06F9/455

CPC分类号： G06F3/065 ,  G06F3/0605 ,  G06F3/0632 ,  G06F3/0676 ,  G06F3/0677 ,  G06F11/1451 ,  G06F11/1458 ,  G06F11/1461

摘要： An emulation component for a data backup system is provided. The emulation component represents a storage device, such as a flash memory device or a partition of a disk drive, as if it were an auto-launch device, that will trigger applications to execute automatically. Accordingly, other computing systems, such as personal computers, interact with the storage device, through the emulation component, as if the storage device were the auto-launch device. Because the emulation component makes this representation, merely connecting the emulation component between the storage device and the computing system can cause a backup application stored on the storage device to automatically execute on the computing system. A data backup appliance including an emulation component and a storage device is also provided. The backup system can also include an interface for connecting another removable device, such as a disk drive, for storing backup content from the data source.

摘要翻译： 提供了一种用于数据备份系统的仿真组件。 仿真组件表示存储设备，例如闪存设备或磁盘驱动器的分区，就像它是自动启动设备一样，将触发应用程序自动执行。 因此，诸如个人计算机的其他计算系统通过仿真组件与存储设备交互，就像存储设备是自动发射设备一样。 由于仿真组件做出这种表示，只需将存储设备和计算系统之间的仿真组件连接起来，就能够使存储在存储设备上的备份应用程序在计算系统上自动执行。 还提供了包括仿真组件和存储设备的数据备份设备。 备份系统还可以包括用于连接另一个可移动设备（如磁盘驱动器）的接口，用于从数据源存储备份内容。