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    Substituted 4-phenyltetrahydroisoquinolinium salts, process for their preparation, their use as a medicament, and medicament containing them
    15.
    发明授权
    Substituted 4-phenyltetrahydroisoquinolinium salts, process for their preparation, their use as a medicament, and medicament containing them 有权
    取代的4-苯基四氢异喹啉盐，其制备方法，它们作为药物的用途，以及含有它们的药物

    公开(公告)号：US06703405B2

    公开(公告)日：2004-03-09

    申请号：US10324041

    申请日：2002-12-20

    Applicant: Armin Hofmeister ,  Hans-Jochen Lang ,  Uwe Heinelt ,  Markus Bleich ,  Klaus Wirth

    Inventor： Armin Hofmeister ,  Hans-Jochen Lang ,  Uwe Heinelt ,  Markus Bleich ,  Klaus Wirth

    IPC: C07D21710

    CPC classification number: C07D217/14 ,  C07D217/10

    Abstract: The invention relates to novel compounds of the formula I in which R1 to R10 R7 are as defined herein. In one embodiment, these compounds may be used as antihypertensives, for reducing or preventing ischemia-induced damage, as medicaments for surgical intervention for the treatment of ischemias of the nervous system, of stroke and of cerebral edema, of shock, of impaired respiratory drive, for the treatment of snoring, as laxative, as agent against ectoparasites, to prevent the formation of gallstones, as antiatherosclerotics, agents against late complications of diabetes, cancers, fibrotic disorders, endothelial dysfunction, organ hypertrophies and hyperplasias. In another embodiment, the compounds may be inhibitors of the cellular sodium-proton antiporter and influence serum lipoproteins and thus be used for the treatment of atherosclerotic lesions.

    Abstract translation: 本发明涉及式Iin的新化合物，其中R 1至R 10 R 7如本文所定义。 在一个实施方案中，这些化合物可以用作抗高血压药物，用于减少或预防缺血诱发的损伤，作为用于治疗神经系统缺血性卒中和脑水肿的外科手术的药物，休克，受损的呼吸驱动 用于治疗打鼾，作为缓泻剂，作为对外寄生虫剂的药剂，以防止胆结石的形成，作为抗动脉粥样硬化剂，用于治疗糖尿病晚期并发症的药物，癌症，纤维化病症，内皮功能障碍，器官肥厚和增生。 在另一个实施方案中，化合物可以是细胞钠 - 质子逆转录酶的抑制剂并影响血清脂蛋白，因此用于治疗动脉粥样硬化病变。

    Use of inhibitors of the KQTI channel and methods of controlling and treating diseases caused by helminths and ectoparasites
    17.
    发明授权
    Use of inhibitors of the KQTI channel and methods of controlling and treating diseases caused by helminths and ectoparasites 有权
    使用KQTI通道抑制剂和控制和治疗由蠕虫和外寄生物引起的疾病的方法

    公开(公告)号：US06335363B1

    公开(公告)日：2002-01-01

    申请号：US09461806

    申请日：1999-12-16

    Applicant: Uwe Gerlach ,  Joachim Hofmann ,  Hans Jochen Lang ,  Aguan Wei

    Inventor： Uwe Gerlach ,  Joachim Hofmann ,  Hans Jochen Lang ,  Aguan Wei

    IPC: A61K3135

    CPC classification number: A61K31/4433 ,  A61K31/00 ,  A61K31/18 ,  A61K31/352 ,  A61K31/353

    Abstract: Use of inhibitors of the KQT1 channel for preparing a medicament for treating diseases caused by helminths and ectoparasites Inhibitors of the KQT1 channel are a novel way of destroying helminths and ectoparasites. For this reason, blockers of the cellular KQT1 channel, which is present in helminths and ectoparasites, are used for preparing a medicament for the treatment of vertebrates and humans infested by helminths or ectoparasites. These KQT1 blockers are used as medicaments on their own or in combination with other medicaments and therapeutic measures. Inhibitors of the KQT1 channel are likewise a novel mechanism of action for phytoparasites such as insects, arachnids, molluscs and nematodes, and consequently, they are used for preparing a crop protection composition.

    Abstract translation: 使用KQT1通道的抑制剂制备用于治疗由蠕虫和外寄生物引起的疾病的药物KQT1通道的抑制剂是破坏蠕虫和外寄生物的新方法。 由于这个原因，存在于蠕虫和外寄生物中的细胞KQT1通道的阻断剂用于制备用于治疗被蠕虫或外寄生虫感染的脊椎动物和人的药物。 这些KQT1阻断剂本身或与其他药物和治疗措施结合使用作为药物.KQT1通道的抑制剂同样是植物寄生虫如昆虫，蜘蛛，软体动物和线虫的新作用机制，因此，它们被使用 准备作物保护组合物。

    Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them
    20.
    发明授权
    Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them 有权
    磺酰胺取代的苯并二氢吡喃染料，其制备方法，它们作为药物或诊断剂的用途，以及包含它们的药物

    公开(公告)号：US06191164B1

    公开(公告)日：2001-02-20

    申请号：US09258289

    申请日：1999-02-26

    Applicant: Hans Jochen Lang ,  Uwe Gerlach ,  Joachim Brendel ,  Henrich Christian Englert ,  Heinz Gögelein ,  Max Hropot ,  Helmut Bohn ,  Andreas Herling ,  Andreas Busch ,  Rainer Greger

    Inventor： Hans Jochen Lang ,  Uwe Gerlach ,  Joachim Brendel ,  Henrich Christian Englert ,  Heinz Gögelein ,  Max Hropot ,  Helmut Bohn ,  Andreas Herling ,  Andreas Busch ,  Rainer Greger

    IPC: A01N4316

    CPC classification number: A61K31/353

    Abstract: Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or a diagnostic, and medicament comprising them Chromans of the formula I and of the formula 1a having the meanings R(A), R(B), R(C) and R(1) to R(8) indicated in the claims are outstandingly suitable for preparing a medicament for blocking the K+ channel which is opened by cyclic adenosine monophosphate (cAMP); and further for preparing a medicament for inhibiting gastric acid secretion; for the treatment of ulcers of the stomach and of the intestinal region, in particular of the duodenum, for the treatment of reflux esophagitis, for the treatment of diarrheal illnesses, for the treatment and prevention of all types of arrhythmias including ventricular and supraventricular arrhythmias, and for the control of reentry arrhythmias and for the prevention of sudden heart death as a result of ventricular fibrillation.

    Abstract translation: 磺酰胺取代的苯并二氢吡喃染色剂，其制备方法，它们作为药物或诊断剂的用途，以及包含它们的药物式I和式1的色素具有R（A），R（B），R（C）和R 1）至权利要求所述的R（8）非常适用于制备用于封闭由环磷酸腺苷（cAMP）打开的K +通道的药物; 并进一步制备用于抑制胃酸分泌的药物; 用于治疗胃和肠道区域，特别是十二指肠的溃疡，用于治疗反流性食管炎，用于治疗腹泻疾病，用于治疗和预防所有类型的心律失常，包括室性和室上性心律失常， 并且用于控制再入心律失常和由于心室颤动而预防心脏死亡。

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