公开(公告)号：US5209746A

公开(公告)日：1993-05-11

申请号：US837183

申请日：1992-02-18

申请人： Stephen M. Balaban ,  James B. Pike ,  Jonathan P. Smith ,  Clifton A. Baile

发明人： Stephen M. Balaban ,  James B. Pike ,  Jonathan P. Smith ,  Clifton A. Baile

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61M5/145

CPC分类号： A61K9/0004 ,  A61M5/14526 ,  A61M2005/14513 ,  A61M2206/10

摘要： Osmotically driven delivery capsules which include a beneficial agent and a water absorptive osmotic engine in separate compartments separated by a movable partition are designed to deliver the beneficial agent in a pulsatile manner through an orifice. The pulsatile delivery is achieved by a series of stops along the inner wall of the capsule which obstruct the movement of the partition but which are overcome in succession as the osmotic pressure rises above a threshold level. The number of stops and their placement longitudinally along the length of the capsule establish the number and frequency of the pulses, and the configuration of the partition controls the pulse intensity.

摘要翻译： 包括有益剂和吸水渗透引擎的渗透驱动输送胶囊被设计成以可动的方式通过孔传送有益剂。 通过沿着胶囊内壁的一系列止动件来实现脉动输送，其阻挡分隔件的移动，但随着渗透压上升到阈值水平以上，它们被连续克服。 沿着胶囊长度方向的停止次数及其位置纵向设置了脉冲的数量和频率，分区的配置控制了脉冲强度。

公开(公告)号：US3966958A

公开(公告)日：1976-06-29

申请号：US491980

申请日：1974-07-26

申请人： Clifton A. Baile ,  Gregory Gallagher ,  Carol Lynn McLaughlin ,  Robert Lee Webb

发明人： Clifton A. Baile ,  Gregory Gallagher ,  Carol Lynn McLaughlin ,  Robert Lee Webb

IPC分类号： A23K1/16 ,  A61K31/27

CPC分类号： A23K20/105

摘要： New methods and compositions for inducing polyphagia in growing or fattening meat producing animals such as sheep or cattle are described using as active ingredients certain carbamates, ureas, oxyureas or ureides. The active ingredients are used most usefully at subhypnotic quantities admixed in animal feed.

摘要翻译： 使用作为活性成分的某些氨基甲酸酯，脲，氧脲或脲类来描述用于在生长或育肥肉类生产动物如绵羊或牛中诱导多食的新方法和组合物。 活性成分最适用于混合在动物饲料中的催眠剂量。

公开(公告)号：USRE28691E

公开(公告)日：1976-01-20

申请号：US561728

申请日：1975-03-25

申请人： Clifton A. Baile ,  Gregory Gallagher ,  Carol L. McLaughlen ,  Robert Lee Webb

发明人： Clifton A. Baile ,  Gregory Gallagher ,  Carol L. McLaughlen ,  Robert Lee Webb

IPC分类号： A23K1/16

CPC分类号： A23K20/105

摘要： New methods and compositions for inducing polyphagia in growing or fattening meat producing animals such as sheep or cattle are described using as active ingredients tertiary alcohols or the corresponding carbamates, ureas, oxyureas or ureides. The active ingredients are used most usefully at sub-hypnotic quantities admixed in animal feed.