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公开(公告)号：US12098199B2
公开(公告)日：2024-09-24
申请号：US17522284
申请日：2021-11-09
发明人： Huamao Wang , Bo Song , Xiumei Cai
IPC分类号： C07K16/28 , A61K35/17 , A61K48/00 , C07K14/705 , C07K14/725 , C07K19/00 , C12N5/10 , C12N15/62 , C12N15/867 , A61K35/12
CPC分类号： C07K16/28 , A61K35/17 , A61K48/00 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K19/00 , C12N5/10 , C12N15/62 , C12N15/867 , A61K2035/124 , C07K2317/53 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C07K2319/70
摘要： Disclosed are a chimeric antigen receptor (CAR) targeting CLD18A2, and preparation method and use thereof. The extracellular binding region of the CAR comprises a protein specifically recognizing CLD18A2. The immune effector cell modified by the CAR can be used to treat tumors such as pancreatic cancer and stomach cancer.
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公开(公告)号：US20230272341A1
公开(公告)日：2023-08-31
申请号：US18020488
申请日：2021-08-10
发明人： Zonghai LI , Ruixin SUN
IPC分类号： C12N5/0783 , C07K16/28 , C07K16/40 , A61P35/00 , C12N15/62
CPC分类号： C12N5/0636 , C07K16/28 , C07K16/40 , A61P35/00 , C12N15/62 , C07K2317/565 , C07K2317/24 , C07K2319/03
摘要： Provided is an immune effector cell targeting FAP and another tumor-associated antigen, which can improve a tumor microenvironment, kill tumor cells, and can be used to treat tumors.
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公开(公告)号：US20230143947A1
公开(公告)日：2023-05-11
申请号：US17761723
申请日：2020-09-21
发明人： Zonghai LI , Hua JIANG
IPC分类号： A61K35/17 , C12N5/0783 , C12N15/86 , C07K14/715 , C07K14/54 , C07K14/555 , A61K45/06 , A61P35/00
CPC分类号： A61K35/17 , C12N5/0636 , C12N15/86 , C07K14/7155 , C07K14/5409 , C07K14/54 , C07K14/555 , A61K45/06 , A61P35/00 , C12N2740/15043
摘要： Provided is a genetically engineered immune effector cell, wherein the immune effector cell expresses a receptor specifically recognizing a target antigen and IL7, and the IL-7 is inducibly expressed and regulated by the receptor. Further provided are a nucleic acid molecule expressing the receptor and IL7 in the immune effector cell and a method for preparing the immune effector cell.
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公开(公告)号：US11530270B2
公开(公告)日：2022-12-20
申请号：US16486481
申请日：2018-02-08
发明人： Peng Wang , Huamao Wang
IPC分类号： C07K16/28 , C07K16/46 , A61P35/00 , A61K35/17 , C07K14/725 , C07K14/705 , C07K14/715 , C12N5/0783 , C12N15/113 , A61K38/00
摘要： Provided is an antibody that specifically recognizes IL-13RA2, which can be used in the manufacture of a targeting anti-tumor medicament as well as a medicament for diagnosing a tumor.
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公开(公告)号：US20220356447A1
公开(公告)日：2022-11-10
申请号：US17623481
申请日：2020-06-29
发明人： Zonghai LI , Zhaohui LIAO
IPC分类号： C12N5/0783 , C07K14/725 , C07K16/28 , C12N15/62 , C12N15/85
摘要： The present invention relates to a cell resistant to transplantation immune rejection. The cell expresses a first protein recognizing one or more immune effector cells of a host; preferably the cell has the function of inhibiting or killing the immune effector cells of the host. The present invention also relates to a method for preventing or regulating transplantation immune rejection, and a method for preventing or regulating the attack of NK cells on exogenous cells.
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公开(公告)号：US20240226151A9
公开(公告)日：2024-07-11
申请号：US18278495
申请日：2022-02-25
发明人： Zonghai LI , Zhimin SHI
CPC分类号： A61K35/17 , A61K39/4631 , A61P35/00 , C07K16/2851 , C12N9/22 , A61K2239/13 , A61K2239/21 , A61K2239/22 , C07K2317/55 , C07K2317/622 , C12N2310/20
摘要： An engineered immune cell for immunotherapy, which has a relatively high persistence and/or survival rate of transplantation in a host organism, and a preparation method therefor.
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公开(公告)号：US20240181055A1
公开(公告)日：2024-06-06
申请号：US18284961
申请日：2022-04-08
发明人： Zonghai LI , Wei WANG , Jun XIAO
IPC分类号： A61K39/00 , A61K31/337 , A61K31/675 , A61K31/7076 , A61P35/00
CPC分类号： A61K39/464411 , A61K31/337 , A61K31/675 , A61K31/7076 , A61K39/4611 , A61K39/4631 , A61K39/464417 , A61P35/00 , A61K2039/545
摘要： A cancer treatment composition and a cancer treatment method. Provided are a cancer treatment method and a treatment composition for patients for whom an anti-PD-1 antibody or anti-PD-L1 antibody treatment has failed.
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公开(公告)号：US20230158071A1
公开(公告)日：2023-05-25
申请号：US17311466
申请日：2019-12-09
发明人： Zonghai LI , Ruixin SUN
IPC分类号： A61K35/17 , A61K31/454 , A61K31/5025 , A61K31/55 , A61K31/551 , C07K14/705 , C07K16/28 , A61K45/06
CPC分类号： A61K35/17 , A61K31/454 , A61K31/5025 , A61K31/55 , A61K31/551 , C07K14/70517 , C07K14/70521 , C07K16/2863 , A61K45/06 , C07K2319/03 , C12N2510/00
摘要： Provided is a method for tumor treatment, comprising administering immune effector cells and a PARP inhibitor to an individual suffering from a tumor, the immune effector cell expresses a receptor for identifying a tumor antigen. Further provided is a kit for tumor treatment.
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公开(公告)号：US20230061005A1
公开(公告)日：2023-03-02
申请号：US17790657
申请日：2021-01-04
发明人： Zonghai LI , Peng WANG , Zhen LIU , Huamao WANG
IPC分类号： C07K16/30 , G01N33/574 , G01N33/563
摘要： Provided is an antibody or antigen binding fragment, capable of recognizing an antigen peptide comprising SEQ ID NO: 7 (KNKKIYDGG); or recognizing an epitope comprising SEQ ID NO: 7 in Claudin 18.2; preferably recognizing a peptide comprising SEQ ID NO: 6 (KNKKIYDGGART); or recognizing an epitope comprising the SEQ ID NO: 6 in the Claudin 18.2.
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公开(公告)号：US11525006B2
公开(公告)日：2022-12-13
申请号：US16479365
申请日：2018-01-23
发明人： Peng Wang , Huamao Wang , Hua Jiang
IPC分类号： C07K16/28 , A61P35/00 , C07K14/725 , C07K14/705 , C12N5/0783 , A61K39/00 , C07K14/525 , C07K14/54 , C07K14/555 , C07K16/46
摘要： Provided in the present invention are a specific antibody of BCMA and a BCMA-targeting immune effector cell, and also provided are a chimeric antigen receptor-modified T cell prepared using the antibody and the use thereof.
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