公开(公告)号：US20240207317A1

公开(公告)日：2024-06-27

申请号：US18539581

申请日：2023-12-14

Applicant: Babraham Institute

Inventor： Martin TURNER ,  Twm Joseff MITCHELL ,  Georg PETKAU ,  David J. TURNER

IPC: A61K35/17 ,  A61K39/00 ,  A61P31/16 ,  C12N5/0783 ,  C12N15/113

CPC classification number: A61K35/17 ,  A61K39/4611 ,  A61K39/4631 ,  A61K39/464838 ,  A61P31/16 ,  C12N5/0638 ,  C12N15/1136

Abstract: The invention relates to a method of enhancing cytotoxic T lymphocyte (CTL) activation and/or proliferation comprising inhibiting or reducing the activity of one or more post-transcriptional regulators of gene expression. Examples of such post-transcriptional regulators include RNA-binding proteins. Also provided is a CTL with enhanced activity and/or proliferative capacity obtainable by the methods defined herein, and a method of treating a disease or disorder in a subject in need thereof comprising administering said CTL with enhanced activity and/or proliferative capacity.

公开(公告)号：US20220282327A1

公开(公告)日：2022-09-08

申请号：US17656063

申请日：2022-03-23

Applicant: Babraham Institute

Inventor： Valeriya MALYSHEVA ,  Stefan SCHOENFELDER ,  Mikhail SPIVAKOV ,  Takashi NAGANO ,  Peter FRASER

IPC: C12Q1/6874 ,  C12Q1/6806 ,  C12N15/10 ,  C12Q1/6855 ,  C12Q1/6876

Abstract: The present invention relates to a method for identifying nucleic acid segments which interact with a target nucleic acid segment or segments as well as kits for performing the method. The invention also relates to a method of identifying one or more interacting nucleic acid segments that are indicative of a particular disease.

公开(公告)号：US09797014B2

公开(公告)日：2017-10-24

申请号：US14382142

申请日：2013-03-01

Applicant: The Babraham Institute

Inventor： Andrew Wood ,  Daniel Bolland ,  Louise Matheson ,  Anne Corcoran

IPC: C12P19/34 ,  C12Q1/68 ,  C07K16/00

CPC classification number: C12Q1/6883 ,  C07K16/00 ,  C12Q1/6881 ,  C12Q2600/158 ,  C12Q2600/16

Abstract: The invention relates to a method of identifying VDJ recombination products which comprises the use of sequence specific enrichment and specific restriction endonuclease enzymes or other DNA-shearing approaches to provide high resolution and high throughput interrogation of antigen receptor repertoires.

公开(公告)号：US20150031042A1

公开(公告)日：2015-01-29

申请号：US14382142

申请日：2013-03-01

Applicant: The Babraham Institute

Inventor： Andrew Wood ,  Daniel Bolland ,  Louise Matheson ,  Anne Corcoran

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C07K16/00 ,  C12Q1/6881 ,  C12Q2600/158 ,  C12Q2600/16

Abstract: The invention relates to a method of identifying VDJ recombination products which comprises the use of sequence specific enrichment and specific restriction endonuclease enzymes or other DNA-shearing approaches to provide high resolution and high throughput interrogation of antigen receptor repertoires.

Abstract translation: 本发明涉及一种鉴定VDJ重组产物的方法，其包括使用序列特异性富集和特异性限制性内切核酸酶或其它DNA剪切方法来提供抗原受体库的高分辨率和高通量询问。