公开(公告)号：US3993762A

公开(公告)日：1976-11-23

申请号：US632995

申请日：1975-11-18

Applicant: Adolf Langbein ,  Herbert Merz ,  Gerhard Walther ,  Klaus Stockhaus

Inventor： Adolf Langbein ,  Herbert Merz ,  Gerhard Walther ,  Klaus Stockhaus

IPC: A61K31/445

Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##SPC1##WhereinR is straight or branched alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 2 carbon atoms or phenyl, andn is an integer from 2 to 4, inclusive,Or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as non-narcotic analgesics.

Abstract translation: 作为活性成分含有下式的化合物的药物组合物WHEREIN R是1〜3个碳原子的直链或支链烷基，1〜2个碳原子的烷氧基或苯基，N是2〜4，包含或A的整数 非毒性，药理学上可接受的酸添加盐; 和使用它作为非功能性分析的方法。

公开(公告)号：US3992542A

公开(公告)日：1976-11-16

申请号：US627208

申请日：1975-10-30

Applicant: Adolf Langbein ,  Herbert Merz ,  Gerhard Walther ,  Klaus Stockhaus

Inventor： Adolf Langbein ,  Herbert Merz ,  Gerhard Walther ,  Klaus Stockhaus

IPC: C07D489/12 ,  A61K31/485

CPC classification number: C07D489/12

Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##SPC1##WhereinR.sub.1 is hydrogen, methyl or acetyl,R.sub.2 is hydrogen or methyl,R.sub.3 is hydrogen, methyl, n-propyl, phenethyl, or phenyl,R.sub.4 is hydrogen or methyl, andZ is --CH=CH-- or --CH.sub.2 --CH.sub.2 --,or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as analgesics and antitussives.

Abstract translation: 作为活性成分含有下式的化合物的药物组合物，其中R 1为氢，甲基或乙酰基，R 2为氢或甲基，R 3为氢，甲基，正丙基，苯乙基或苯基，R 4为氢或甲基，Z为 是-CH = CH-或-CH 2 -CH 2 - ，或其无毒的药学上可接受的酸加成盐; 以及使用其作为镇痛药和镇咳药的方法。

公开(公告)号：US3931189A

公开(公告)日：1976-01-06

申请号：US369500

申请日：1973-06-13

Applicant: Adolf Langbein ,  Herbert Merz ,  Gerhard Walther ,  Kalus Stockhaus

Inventor： Adolf Langbein ,  Herbert Merz ,  Gerhard Walther ,  Kalus Stockhaus

IPC: A61K31/485 ,  A61P11/14 ,  A61P25/04 ,  A61P25/30 ,  C07D489/02 ,  C07D489/12

CPC classification number: C07D489/12 ,  C07D489/02 ,  Y10S514/849

Abstract: Compounds of the formula ##SPC1##WhereinR.sub.1 is hydrogen, methyl or acetyl,R.sub.2 is hydrogen or methyl,R.sub.3 is hydrogen, methyl, n-propyl, phenethyl or phenyl,R.sub.4 is hydrogen or methyl,Z is --CH=CH-- or --CH.sub.2 --CH.sub.2 --, andY is oxygen or sulfur,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as analgesics and antitussives.

Abstract translation: 式WHEREIN R 1的化合物是氢，甲基或乙酰基，R 2是氢或甲基，R 3是氢，甲基，正丙基，苯乙基或苯基，R 4是氢或甲基，Z是-CH = CH-或-CH 2 - CH2-和Y是氧或硫，以及非毒性，药理学上可接受的酸添加量; 这些化合物作为它们的有效的有效的化学和抗生素。

公开(公告)号：US5767279A

公开(公告)日：1998-06-16

申请号：US513582

申请日：1995-08-10

Applicant: Adolf Langbein ,  Heinrich Schneider ,  Gerd-Rainer Bressler

Inventor： Adolf Langbein ,  Heinrich Schneider ,  Gerd-Rainer Bressler

IPC: B01J23/42 ,  B01J23/44 ,  C07B53/00 ,  C07B57/00 ,  C07B61/00 ,  C07D213/38

CPC classification number: C07D213/38

Abstract: The present invention relates to new enantiomerically pure pyridylcycloalkylethylamines of formula 1a and 1b, the salts thereof as well as to methods of preparing them and their use as intermediate products. ##STR1##

Abstract translation: 本发明涉及式1a和1b的新的对映体纯的吡啶基环烷基乙胺及其盐，以及它们的制备方法及其作为中间产物的用途。 1b。图像1a

公开(公告)号：US5006533A

公开(公告)日：1991-04-09

申请号：US440917

申请日：1989-11-22

Applicant: Rainer Sobotta ,  Adolf Langbein ,  Herbert Merz ,  Rudolf Bauer ,  Joachim Mierau

Inventor： Rainer Sobotta ,  Adolf Langbein ,  Herbert Merz ,  Rudolf Bauer ,  Joachim Mierau

IPC: C07D221/22 ,  A61K31/435 ,  A61P25/00 ,  A61P25/02 ,  A61P25/20 ,  C07D451/04 ,  C07D471/02

CPC classification number: C07D451/04

Abstract: 3-Bromo-2,6-dimethoxybenzamides useful as neuroleptic agents are described.

Abstract translation: 描述了用作神经安定药的3-溴-2,6-二甲氧基苯甲酰胺。

公开(公告)号：US4393069A

公开(公告)日：1983-07-12

申请号：US324680

申请日：1981-11-25

Applicant: Adolf Langbein ,  Herbert Merz ,  Rainer Sobotta ,  Rudolf Bauer ,  Hans M. Jennewein ,  Joachim Mierau

Inventor： Adolf Langbein ,  Herbert Merz ,  Rainer Sobotta ,  Rudolf Bauer ,  Hans M. Jennewein ,  Joachim Mierau

IPC: A61K31/46 ,  A61K31/49 ,  A61P5/00 ,  C07D451/06 ,  C07D401/02

CPC classification number: C07D451/06

Abstract: Compounds of the formula ##STR1## wherein Ar is ##STR2## R.sub.1 is hydrogen, fluorine, bromine, methyl or methoxy; X is .dbd.CO, .dbd.CH--CN, .dbd.CH--OH, --O--, --S--, --NH--, ##STR3## and R is hydrogen, 4-fluoro, 4-chloro, 4-trifluoromethyl, 3-trifluoromethyl, 3-trifluoromethyl-4-chloro, 4-methyl or 4-methoxy;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as neuroleptics.

Abstract translation: 其中Ar为R 1的式“IMAGE”的化合物是氢，氟，溴，甲基或甲氧基; X为= CO，= CH-CN，= CH-OH，-O - ， - S - ， - NH-，+ IMA，其中R为氢，4-氟，4-氯， 三氟甲基，3-三氟甲基，3-三氟甲基-4-氯，4-甲基或4-甲氧基; 和无毒的，药学上可接受的酸加成盐。 化合物及其盐可用作神经安定药。

公开(公告)号：US4201712A

公开(公告)日：1980-05-06

申请号：US783143

申请日：1977-03-31

Applicant: Karl-Heinz Weber ,  Adolf Bauer ,  Adolf Langbein

Inventor： Karl-Heinz Weber ,  Adolf Bauer ,  Adolf Langbein

IPC: C07D333/36 ,  C07D495/04 ,  C07D495/14 ,  C07D409/04

CPC classification number: C07D495/04 ,  C07D333/36 ,  C07D495/14

Abstract: A multiple-step process for the preparation of 6-aryl-4H-s-triazolo-[3,4-c]-thieno-[2,3-e]-1,4-diazepines of the formula ##STR1## wherein R.sub.1 is hydrogen, halogen or lower alkyl of 1 to 2 carbon atoms;R.sub.2 is hydrogen, chlorine, bromine, straight or branched alkyl of 1 to 3 carbon atoms, .omega.-hydroxyalkyl of 1 to 3 carbon atoms, cycloalkyl of 3 to 6 carbon atoms or a 5- or 6-membered heterocycle comprising an oxygen sulfur or nitrogen atom, where the nitrogen atom may optionally be substituted by lower alkyl; andR.sub.3 is hydrogen, fluorine, chlorine, or bromine;and optionally acid addition salts thereof, starting from compounds of the formula ##STR2## wherein R.sub.1 and R.sub.3 have the meanings defined above, andX is halogen, amino or acyloxy.

Abstract translation: 制备式“IMAGE”的6-芳基-4H-三唑并[3,4-c] - 噻吩并[2,3-e] -1,4-二氮杂的多步法，其中R 1 是氢，卤素或1〜2个碳原子的低级烷基; R 2是氢，氯，溴，1至3个碳原子的直链或支链烷基，1至3个碳原子的ω-羟基烷基，3至6个碳原子的环烷基或包含氧硫的5-或6-元杂环 氮原子，其中氮原子可以任选被低级烷基取代; 并且R 3是氢，氟，氯或溴; 和其任选的酸加成盐，其由式（I）的化合物开始，其中R 1和R 3具有上述定义，且X为卤素，氨基或酰氧基。

公开(公告)号：US4085216A

公开(公告)日：1978-04-18

申请号：US794937

申请日：1977-05-09

Applicant: Adolf Langbein ,  Karl-Heinz Weber ,  Adolf Bauer ,  Karin Boke ,  Erich Lehr ,  Franz Josef Kuhn

Inventor： Adolf Langbein ,  Karl-Heinz Weber ,  Adolf Bauer ,  Karin Boke ,  Erich Lehr ,  Franz Josef Kuhn

IPC: A61K31/435 ,  A61P25/20 ,  C07D471/04 ,  A61K31/44 ,  C07D471/14

CPC classification number: C07D471/04

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, halogen or methyl, andR.sub.2 is hydrogen, halogen, methyl or methoxy, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as neuroleptics.

Abstract translation: 其中R 1为氢，卤素或甲基，R 2为氢，卤素，甲基或甲氧基的化合物及其无毒的药学上可接受的酸加成盐; 化合物及其盐可用作精神安定药。

公开(公告)号：US4069331A

公开(公告)日：1978-01-17

申请号：US760001

申请日：1977-01-17

Applicant: Adolf Langbein ,  Peter Danneberg ,  Franz Josef Kuhn

Inventor： Adolf Langbein ,  Peter Danneberg ,  Franz Josef Kuhn

IPC: C07D211/58

CPC classification number: C07D211/58

Abstract: Compounds of the formula ##STR1## wherein R is straight or branched alkyl of 1 to 4 carbon atoms, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as sedatives and tranquilizers.

Abstract translation: 其中R是1至4个碳原子的直链或支链烷基的式（IMAGE）化合物及其无毒的药学上可接受的酸加成盐; 化合物及其盐可用作镇静剂和镇静剂。

公开(公告)号：US3931187A

公开(公告)日：1976-01-06

申请号：US369499

申请日：1973-06-13

Applicant: Adolf Langbein ,  Herbert Merz ,  Gerhard Walther ,  Klaus Stockhaus

Inventor： Adolf Langbein ,  Herbert Merz ,  Gerhard Walther ,  Klaus Stockhaus

IPC: A61K31/485 ,  A61P11/14 ,  A61P25/04 ,  C07D489/02 ,  C07D489/12

CPC classification number: C07D489/12 ,  A61K31/485 ,  C07D489/02 ,  Y02P20/55 ,  Y10S514/849

Abstract: Compounds of the formula ##SPC1##WhereinR is hydrogen, methyl or acetyl,R.sub.1 is methyl, phenyl, or hydrogen,Z is --CH=CH-- or --CH.sub.2 --CH.sub.2 --,Y is oxygen or sulfur, andR.sub.3 is hydrogen or methyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as analgesics and antitussives.

Abstract translation: 式WHEREIN R的化合物是氢，甲基或乙酰基，R 1是甲基，苯基或氢，Z是-CH = CH-或-CH 2 -CH 2 - ，Y是氧或硫，R 3是氢或甲基，AND 非毒性，药理学上可接受的酸添加量; 这些化合物作为它们的有效的有效的化学和抗生素。