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公开(公告)号:US20150376283A1
公开(公告)日:2015-12-31
申请号:US14754229
申请日:2015-06-29
Applicant: GENENTECH, INC.
Inventor: Junichiro Sonoda , Yan Wu
IPC: C07K16/28 , A61K39/395 , C07K16/40 , A61K45/06
CPC classification number: C07K16/2863 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K16/40 , C07K2317/31 , C07K2317/34 , C07K2317/35 , C07K2317/56 , C07K2317/75 , C07K2317/92
Abstract: The invention provides FGFR1 agonists, including agonistic anti-FGFR1 antibodies, and methods of using the same.
Abstract translation: 本发明提供FGFR1激动剂,包括激动性抗FGFR1抗体及其使用方法。
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公开(公告)号:US09200072B2
公开(公告)日:2015-12-01
申请号:US13744766
申请日:2013-01-18
Applicant: Genentech, Inc.
Inventor: Yan Wu , Weilan Ye , Jeremy Bryant Burton , Cecilia Chiu
IPC: C07K16/28 , A61K39/395 , A61K39/00
CPC classification number: C07K16/28 , A61K39/395 , A61K47/6849 , A61K2039/505 , A61P9/10 , A61P27/02 , C07H21/04 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/567 , C07K2317/75 , C07K2317/92
Abstract: The invention provides anti-LRP5 antibodies and methods of making and using the same.
Abstract translation: 本发明提供抗LRP5抗体及其制备和使用方法。
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公开(公告)号:US20150147333A1
公开(公告)日:2015-05-28
申请号:US14517709
申请日:2014-10-17
Applicant: GENENTECH, INC.
Inventor: Elaine Storm , Frederic J. de Sauvage , Jeremy M. Murray , Cameron L. Noland , Yan Wu , Christine Tan , Jo-Anne Hongo , Yongmei Chen
IPC: C07K16/18 , A61K39/395 , A61K45/06 , A61K47/48
CPC classification number: C07K16/18 , A61K39/3955 , A61K45/06 , A61K47/6843 , A61K2039/505 , C07K16/2818 , C07K16/3046 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/75 , C07K2317/76 , C07K2317/92
Abstract: Provided herein are anti-RSPO antibodies, in particular anti-RSPO2 antibodies and/or anti-RSPO3 antibodies, and methods of using the same.
Abstract translation: 本文提供抗RSPO抗体,特别是抗RSPO2抗体和/或抗RSPO3抗体,以及使用该抗RSP2抗体的方法。
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公开(公告)号:US20140314782A1
公开(公告)日:2014-10-23
申请号:US14051699
申请日:2013-10-11
Applicant: Genentech, Inc.
Inventor: Siebel W. Christian , Yan Wu
IPC: C07K16/28
CPC classification number: C07K16/28 , A61K2039/505 , C07K16/30 , C07K16/3053 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: The invention provides anti-Notch antibodies, and in particular, antibodies that bind Notch2 NRR, and methods of using the same.
Abstract translation: 本发明提供抗Notch抗体,特别是结合Notch2 NRR的抗体及其使用方法。
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公开(公告)号:US08853369B2
公开(公告)日:2014-10-07
申请号:US13708685
申请日:2012-12-07
Applicant: Genentech, Inc.
Inventor: Lin Pei , Yan Wu , Xiaofen Ye
CPC classification number: A61K45/06 , A61K39/39558 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K16/2863 , C07K2317/21 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , A61K2300/00
Abstract: The invention provides anti-Axl antibodies and methods of using the same.
Abstract translation: 本发明提供抗Ax1抗体及其使用方法。
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公开(公告)号:US20140296488A1
公开(公告)日:2014-10-02
申请号:US14177435
申请日:2014-02-11
Applicant: Genentech, Inc.
Inventor: Christian W. Siebel , Yan Wu
IPC: C07K16/28
CPC classification number: C07K16/30 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/705 , C07K14/71 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K16/3015 , C07K2317/14 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N5/10 , C12N5/12 , C12N15/09 , C12N15/63 , C12N2330/50
Abstract: The invention provides anti-Notch1 NRR antibodies, and compositions comprising and methods of using these antibodies.
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137.
公开(公告)号:US20140271624A1
公开(公告)日:2014-09-18
申请号:US14177452
申请日:2014-02-11
Applicant: Genentech, Inc.
Inventor: Christian W. Siebel , Yan Wu
IPC: C07K16/18 , A61K45/06 , A61K39/395
CPC classification number: C07K16/30 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/705 , C07K14/71 , C07K16/18 , C07K16/28 , C07K16/2863 , C07K16/3015 , C07K2317/14 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N5/10 , C12N5/12 , C12N15/09 , C12N15/63 , C12N2330/50
Abstract: The invention provides anti-Notch1 NRR antibodies, and compositions comprising and methods of using these antibodies.
Abstract translation: 本发明提供抗Notch1NRR抗体,以及包含使用这些抗体的组合物。
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公开(公告)号:US20140187754A1
公开(公告)日:2014-07-03
申请号:US14197072
申请日:2014-03-04
Applicant: Genentech, Inc.
Inventor: Avi Ashkenazi , Jing Qing , Christian Wiesmann , Yan Wu
IPC: C07K16/28
CPC classification number: C07K16/2863 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K2039/505 , C07K16/3038 , C07K16/3061 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30
Abstract: The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.
Abstract translation: 本发明提供FGFR3抗体,以及组合物和使用这些抗体的方法。
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139.
公开(公告)号:US20130217862A1
公开(公告)日:2013-08-22
申请号:US13765625
申请日:2013-02-12
Applicant: Genentech, Inc.
Inventor: Daniel K. Kirchhofer , Yan Wu
IPC: C07K16/22
CPC classification number: C07K16/22 , C07K16/32 , C07K16/40 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The invention provides methods and compositions for modulating hepatocyte growth factor activator function.
Abstract translation: 本发明提供调节肝细胞生长因子激活功能的方法和组合物。
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公开(公告)号:US20130183320A1
公开(公告)日:2013-07-18
申请号:US13744766
申请日:2013-01-18
Applicant: Genentech, Inc.
Inventor: Yan Wu , Weilan Ye , Jeremy Bryant Burton , Cecilia Chiu
IPC: C07K16/28
CPC classification number: C07K16/28 , A61K39/395 , A61K47/6849 , A61K2039/505 , A61P9/10 , A61P27/02 , C07H21/04 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/567 , C07K2317/75 , C07K2317/92
Abstract: The invention provides anti-LRP5 antibodies and methods of making and using the same.
Abstract translation: 本发明提供抗LRP5抗体及其制备和使用方法。
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