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公开(公告)号：US20210330972A1
公开(公告)日：2021-10-28
申请号：US17318824
申请日：2021-05-12
申请人： ELECTROCORE, INC
发明人： Bruce J. Simon , Joseph P. Errico
摘要： Methods for treating medical disorders, such as migraine or other primary headaches, or fibromyalgia, by electrical stimulation of a nerve. The method comprises applying a first stimulus to a patient having a medical condition and measuring a first baseline physiological response from the patient. An electrical impulse is applied to a nerve within the patient and second stimulus is applied to the patient. A second physiological response evoked by the second stimulus is measured and compared to the first baseline physiological response. The methods may be used to optimize the placement of a stimulator, to test whether a patient is a suitable candidate for treatment using nerve stimulation, and/or to select the stimulation parameters that optimize acute or chronic treatment.
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公开(公告)号：US11065444B2
公开(公告)日：2021-07-20
申请号：US16535205
申请日：2019-08-08
申请人： ElectroCore, Inc.
发明人： Joseph P. Errico , Steven Mendez , Bruce J. Simon
摘要： Devices and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache and trigeminal neuralgia and the like, by noninvasive electrical stimulation of nerves of the head, particularly supraorbital, supratrochlear, infraorbital, and mental nerves in the vicinity of their foramen or notch. The system comprises a handheld mobile device, such as a smartphone, that is applied to the surface of the patient's head. One or more electrodes on the mobile device apply electrical impulses transcutaneously through the patient's skin to the targeted nerve to treat the medical condition. The system is designed to address problems that arise particularly during self-treatment, when a medical professional is not present.
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公开(公告)号：US20200246617A1
公开(公告)日：2020-08-06
申请号：US16854034
申请日：2020-04-21
申请人： ElectroCore, Inc.
摘要： Systems and methods for reducing or inhibiting an inflammatory response in a patient include a source of energy and one or more electrodes coupled to the source of energy and positionable near a vagus nerve of the patient to deliver the electrical impulse to the vagus nerve. The electrical impulse is sufficient to either inhibit a release of a pro-inflammatory cytokine, such as TNF-alpha, or increase an anti-inflammatory competence of a cytokine, such as TGF-beta, in the patient, thereby inhibiting the inflammatory response. The electrical impulse may be delivered transcutaneously and non-invasively through an outer skin surface of the patient to the vagus nerve.
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公开(公告)号：US20200222708A1
公开(公告)日：2020-07-16
申请号：US16830607
申请日：2020-03-26
申请人： ElectroCore, Inc.
IPC分类号： A61N2/00 , A61H23/00 , A61H23/02 , A61H31/00 , A61H39/00 , A61N1/36 , A61N1/40 , A61N2/02 , A61N5/06 , A61N1/375 , A61N1/378 , A61N7/00
摘要： Devices, systems and methods are provided for treating a disease or disorder in a patient. The methods incluce positioning a surface of a housing in contact with an outer skin surface of the patient and applying sufficient energy to an energy transmitter within the housing via a power supply to generate an electrical impulse at or near a vagus nerve of the patient. The the electrical impulse is sufficient to modulate fibers of the vagus nerve and treat the disease or disorder.
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公开(公告)号：US20200086108A1
公开(公告)日：2020-03-19
申请号：US16693088
申请日：2019-11-22
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico
摘要： Devices, systems and methods are disclosed for reducing inflammation associated with an aneurysm in a patient. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in the vagus nerve. Vagus nerve stimulation is used to modulate the release of neurotransmitters in the brain and to reduce inflammation that may lead to the formation, growth, rupture or hemorrhage of an aneurysm.
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公开(公告)号：US20200046976A1
公开(公告)日：2020-02-13
申请号：US16598127
申请日：2019-10-10
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Methods and devices are disclosed for the non-invasive treatment of neurodegenerative diseases through delivery of energy to target nervous tissue, particularly the vagus nerve. The methods and devices transmit an electrical impulse transcutaneously through an outer skin surface of the patient to modulate activity of a selected nerve at the target region to inhibit inflammation, enhance an anti-inflammatory competence of a cytokine in the patient and treat the neurodegenerative disorder. The stimulation brings about reduction of neuroinflammation in patients suffering from conditions comprising Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, postoperative cognitive dysfunction and postoperative delirium.
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公开(公告)号：US20200001083A1
公开(公告)日：2020-01-02
申请号：US16540476
申请日：2019-08-14
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
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公开(公告)号：US20190299000A1
公开(公告)日：2019-10-03
申请号：US16416634
申请日：2019-05-20
申请人： ElectroCore, Inc.
发明人： Joseph P. Errico , Steven Mendez , Bruce J. Simon
摘要： Devices, systems and methods are disclosed that allow a patient to self-treat neurodegenerative diseases, such as dementia, Alzheimer's disease, ischemic stroke, post-concussion syndrome, chronic traumatic encephalopathy and the like by electrical noninvasive stimulation of a vagus nerve. The system comprises a handheld stimulator that is applied to the surface of the patient's neck, wherein the stimulator comprises or is joined to a smartphone. A camera of the smartphone may be used to position and reposition the stimulator to a particular location on the patient's neck. The system may also comprise a base station that is used to meter the charging of a rechargeable battery within the stimulator. The base station and stimulator transmit data to one another regarding the status of a stimulation session.
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公开(公告)号：US20190240486A1
公开(公告)日：2019-08-08
申请号：US16388392
申请日：2019-04-18
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
CPC分类号： A61N1/36025 , A61N1/36114 , A61N1/40 , A61N2/002 , A61N2/006 , A61N2/02
摘要： Methods and devices are disclosed for the non-invasive treatment of neurodegenerative diseases through delivery of energy to target nervous tissue, particularly the vagus nerve. The devices include a magnetic stimulator having coils with toroidal windings, which are in contact with an electrically conducting medium that is adapted to conform to the contour of a target body surface of a patient. The coils induce an electric current and/or an electric field within the patient, thereby stimulating nerve fibers within the patient. The stimulation brings about reduction of neuroinflammation in patients suffering from conditions comprising Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, postoperative cognitive dysfunction and postoperative delirium. Reduction in inflammation is effected by enhancing the anti-inflammatory competence of cytokines such as TGF-beta, wherein a retinoid or components of the retinoic acid signaling system provide an anti-inflammatory bias, by enhancing anti-inflammatory activity of a neurotrophic factor such as NGF, GDNF, BDNF, or MANF, and/or by inhibiting the activity of pro-inflammatory cytokines such as TNF-alpha.
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100.发明申请公开(公告)号：US20190209839A1
公开(公告)日：2019-07-11
申请号：US16284852
申请日：2019-02-25
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
CPC分类号： A61N1/36014 , A61N1/0456 , A61N1/36053 , A61N1/36114 , A61N1/36171 , A61N1/36178 , A61N1/362 , A61N1/3625 , A61N1/375 , A61N2/006 , A61N2/02
摘要： Energy is transmitted noninvasively to a patient using electrode-based stimulation devices or magnetic stimulation devices that are designed to non-invasively stimulate nerves selectively. The devices produce impulses that are used to treat atrial fibrillation, by stimulating a vagus nerve of a patient. The devices are also used to forecast the imminent onset of atrial fibrillation and then avert it by stimulating a vagus nerve.
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