公开(公告)号：US20250019457A1

公开(公告)日：2025-01-16

申请号：US18758187

申请日：2024-06-28

Applicant: iBio, Inc.

Inventor： Dillon Phan ,  Cory Schwartz ,  Matthew P. Greving ,  Cody A. Moore ,  Tam Thi Thanh Phuong ,  Matthew Dent ,  Alexander T. Taguchi ,  Jiang Chen ,  Tom Sih-Yuan Hsu ,  Domyoung Kim ,  Martin Brenner

IPC: C07K16/30 ,  C07K16/28

Abstract: Provided herein are anti-Trop 2 antibodies or binding fragments thereof that bind Trop 2, e.g., human Trop 2. The anti-Trop 2 antibodies of the disclosure are useful for the treatment of proliferative disorders or cells that express Trop 2 or mutant Trop 2. Also provided herein are methods of use for the anti-Trop 2 antibodies or binding fragments thereof, as well as bi-valent or multi-valent anti-Trop 2 antibodies or binding fragments thereof that may form complexes that attract immune effectors or binding to other cells, such as, a second antibody, antigen-binding of the second antibody or fragment thereof; a target-binding protein, a cytokine; a lectin; or a toxin.