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1.发明申请VAGUS NERVE STIMULATION WITH TARGET EFFECTS CONTROLLED BY ADJUSTING TEMPORAL PARAMETERS 有权VAGUS神经刺激与调整时间参数控制的目标效应公开(公告)号：US20110301659A1
公开(公告)日：2011-12-08
申请号：US13114686
申请日：2011-05-24
CPC分类号： A61N1/36053 , A61B5/04001 , A61B5/0488 , A61B5/4029 , A61B5/4035 , A61N1/0556 , A61N1/18 , A61N1/36 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N1/36167
摘要： One or more temporal stimulation parameters of vagus nerve stimulation (VNS) are selected to substantially modulate one or more target physiological functions without substantially modulating one or more non-target physiological functions. In one embodiment, a stimulation duty cycle is selected such that VNS is delivered to the cervical vagus nerve trunk to modulate a cardiovascular function without causing laryngeal muscle contractions.
摘要翻译： 选择迷走神经刺激（VNS）的一个或多个时间刺激参数以基本上调制一个或多个目标生理功能，而基本上不调制一个或多个非目标生理功能。 在一个实施例中，选择刺激占空比使得VNS被递送到子宫颈迷走神经干以调节心血管功能而不引起喉部肌肉收缩。
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2.发明授权Vagus nerve stimulation with target effects controlled by adjusting temporal parameters 有权通过调整时间参数控制目标效应的迷走神经刺激公开(公告)号：US09042981B2
公开(公告)日：2015-05-26
申请号：US13114686
申请日：2011-05-24
CPC分类号： A61N1/36053 , A61B5/04001 , A61B5/0488 , A61B5/4029 , A61B5/4035 , A61N1/0556 , A61N1/18 , A61N1/36 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N1/36167
摘要： One or more temporal stimulation parameters of vagus nerve stimulation (VNS) are selected to substantially modulate one or more target physiological functions without substantially modulating one or more non-target physiological functions. In one embodiment, a stimulation duty cycle is selected such that VNS is delivered to the cervical vagus nerve trunk to modulate a cardiovascular function without causing laryngeal muscle contractions.
摘要翻译： 选择迷走神经刺激（VNS）的一个或多个时间刺激参数以基本上调制一个或多个目标生理功能，而基本上不调制一个或多个非目标生理功能。 在一个实施例中，选择刺激占空比使得VNS被递送到子宫颈迷走神经干以调节心血管功能而不引起喉部肌肉收缩。
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公开(公告)号：US20110301658A1
公开(公告)日：2011-12-08
申请号：US13114626
申请日：2011-05-24
CPC分类号： A61N1/36053 , A61B5/04001 , A61B5/0488 , A61B5/4029 , A61N1/0556 , A61N1/36114 , A61N1/36167
摘要： By targeting on selected branches or fascicles of a vagus nerve using electrode placement and/or selection, one or more target branches of the vagus nerve are substantially activated by electrical stimulation pulses delivered to a branch without substantially activating one or more non-target branches. In one embodiment, vagus nerve stimulation is delivered through an electrode placed on a thoracic vagus nerve that is separated from a recurrent laryngeal nerve, such that the vagus nerve is stimulated without causing laryngeal muscle contractions. In another embodiment, vagus nerve stimulation is delivered through a multi-contact electrode with one or more contacts selected for delivering the electrical stimulation pulses to stimulate the vagus nerve without causing laryngeal muscle contractions.
摘要翻译： 通过使用电极放置和/或选择来靶向迷走神经的选定分支或分支，迷走神经的一个或多个目标分支基本上被传递到分支的电刺激脉冲激活，而基本上不激活一个或多个非目标分支。 在一个实施例中，迷走神经刺激通过放置在与复发性喉部神经分离的胸部迷走神经上的电极递送，使得迷走神经被刺激而不引起喉部肌肉收缩。 在另一个实施方案中，迷走神经刺激通过多接触电极递送，其中一个或多个触点被选择用于递送电刺激脉冲以刺激迷走神经而不引起喉部肌肉收缩。
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公开(公告)号：US08509919B2
公开(公告)日：2013-08-13
申请号：US13114626
申请日：2011-05-24
IPC分类号： A61N1/18
CPC分类号： A61N1/36053 , A61B5/04001 , A61B5/0488 , A61B5/4029 , A61N1/0556 , A61N1/36114 , A61N1/36167
摘要： By targeting on selected branches or fascicles of a vagus nerve using electrode placement and/or selection, one or more target branches of the vagus nerve are substantially activated by electrical stimulation pulses delivered to a branch without substantially activating one or more non-target branches. In one embodiment, vagus nerve stimulation is delivered through an electrode placed on a thoracic vagus nerve that is separated from a recurrent laryngeal nerve, such that the vagus nerve is stimulated without causing laryngeal muscle contractions. In another embodiment, vagus nerve stimulation is delivered through a multi-contact electrode with one or more contacts selected for delivering the electrical stimulation pulses to stimulate the vagus nerve without causing laryngeal muscle contractions.
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