公开(公告)号：US20230203101A1

公开(公告)日：2023-06-29

申请号：US17920526

申请日：2021-04-22

Applicant: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION ,  KOREA NATIONAL INSTITUTE OF HEALTH ,  BIOAPPLICATIONS INC

Inventor： In Hwan HWANG ,  Shijian SONG ,  Rezaul Islam Khan MD ,  Haiping DIAO ,  Eun Ju SOHN ,  Bo Hwa CHOI ,  Jang Hoon CHOI ,  Eun Young JANG ,  Young Jae LEE

IPC: C07K14/005 ,  C12N15/82

CPC classification number: C07K14/005 ,  C12N15/8258 ,  C12N2770/20022 ,  C12N2770/20071 ,  C12N2770/20034 ,  C12N2770/20043 ,  C12N2770/20051 ,  C12N2511/00

Abstract: The present invention relates to a recombinant spike protein of the COVID-19 virus forming a trimer and a method for mass-producing the recombinant spike protein, and more specifically to a method for designing a recombinant gene expressing a recombinant spike protein of the COVID-19 virus forming a trimer for the purposes of enhancing immunogenicity and effective antigen delivery, and a method for mass-producing the recombinant spike protein in plants.

公开(公告)号：US20250011376A1

公开(公告)日：2025-01-09

申请号：US18708261

申请日：2022-09-15

Applicant: POSTECH Research and Business Development Foundation

Inventor： In Hwan HWANG ,  A Reum YUN ,  Byeong Ho MOON ,  Shijian SONG ,  Haiping DIAO

IPC: C07K14/315 ,  C07K14/005 ,  C07K14/435 ,  C07K14/54 ,  C12N15/82

Abstract: The present invention relates to a GB1 domain fusion structure for upregulating recombinant protein expression in plants and, more specifically, to a GB1 domain fusion structure in which the GB1 domain of Streptococcus-derived protein G is fused with a target protein to be expressed in an upregulated manner, and a method for upregulating expression of a recombinant protein by using same. The present invention can bring about a reduced risk of contamination by pathogens and a high production yield, compared to the case of employing animal cells or microbes conventionally established to produce recombinant proteins, and a remarkable improvement in recombinant protein output, compared to the conventional case of employing plants. Thus, the present invention has several advantages in terms of quality and economy and thus can be a very competitive production method in the commercial production of recombinant proteins.

公开(公告)号：US20230173055A1

公开(公告)日：2023-06-08

申请号：US17995872

申请日：2021-04-22

Applicant: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION ,  BIOAPPLICATIONS INC ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY ,  KONKUK UNIVERSITY INDUSTRIAL COOPERATION CORP

Inventor： In Hwan HWANG ,  Jun Ho LEE ,  Diao HAIPING ,  Shijian SONG ,  Woe Yeon KIM ,  Min Gab KIM ,  Gyeong Ryul RYU ,  Gyeong Im SHIN ,  Chang Seon SONG ,  Ji Ho LEE ,  Deok Hwan KIM

IPC: A61K39/145 ,  C07K14/005 ,  C12N15/82 ,  A61P31/16

CPC classification number: A61K39/145 ,  C07K14/005 ,  C12N15/8258 ,  A61P31/16 ,  C12N2760/16122 ,  C12N2760/16151 ,  C12N2760/16134 ,  A61K2039/521

Abstract: The present invention relates to an influenza virus surface protein-derived recombinant hemagglutinin (HA) protein forming a trimer and use thereof, and more specifically to a recombinant vector for producing an influenza virus surface protein-derived HA protein forming a trimer, a transformant transformed by the recombinant vector, a method for producing an influenza virus surface protein-derived HA protein forming a trimer using the recombinant vector, an influenza virus surface protein-derived HA protein produced by the method, and the use thereof in preventing, ameliorating or treating influenza virus-infected disease.