公开(公告)号：US20230176076A1

公开(公告)日：2023-06-08

申请号：US17296306

申请日：2019-11-27

Applicant: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION ,  DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Il Doo HWANG ,  Hyun Woo CHO ,  Sung Bae LEE ,  Hyun Seob CHO

IPC: G01N33/68 ,  G01N33/574 ,  A61P25/28 ,  A61K38/16 ,  A61P35/00

CPC classification number: G01N33/6896 ,  A61K38/168 ,  A61P25/28 ,  A61P35/00 ,  G01N33/574

Abstract: The present disclosure relates to a use of JULGI in diagnosing and treating guanine quadruplex-related disease and, more particularly, to a guanine-quadruplex (G-quadruplex) detecting composition comprising JULGI protein or a protein having a homology of 80% or higher to the JULGI protein, a diagnostic composition comprising the detecting composition, a diagnostic kit comprising the diagnostic composition, a method for providing information for diagnosis of a neurodegenerative disease, cancer, or a viral infection disease which are in pathological correlation with G-quadruplex, and a pharmaceutical composition for prevention or treatment of a neurodegenerative disease, cancer, or a viral infection disease, the pharmaceutical composition comprising JULGI protein, a protein having a homology of 80% or more with the JULGI protein, or a mutant protein thereof. Thanks to the activity of binding to the G-quadruplex structure, JULGI according to the present disclosure is expected to be advantageously used in diagnosing or treating various diseases that are in pathological correlation with the abnormal formation and dissociation of the G-quadruplex structure.

公开(公告)号：US20240052002A1

公开(公告)日：2024-02-15

申请号：US18365274

申请日：2023-08-04

Applicant: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION

Inventor： Ho Young NAM ,  Il Doo HWANG

IPC: C07K14/415 ,  C12N15/82

CPC classification number: C07K14/415 ,  C12N15/8213 ,  C12N15/8226 ,  C12N15/8218 ,  C12N2310/20

Abstract: The present invention relates to a composition for enhancing the sink strength of a sink tissue of a plant. The composition can increase the number of phloem cells and phloem transport velocity by suppressing the expression of an SlJUL protein or a gene encoding the SlJUL protein. Therefore, the present invention can be usefully used to increase the productivity and yield of agricultural crops.