公开(公告)号：US20160297892A1

公开(公告)日：2016-10-13

申请号：US15033835

申请日：2014-11-07

Applicant: NOVO NORDISK A/S

Inventor： Helle Heibroch Petersen ,  Mette Brunsgaard Hermit ,  Heidi Lindgreen Holmberg ,  Berit Olsen Krogh ,  Kristian Kjaergaard ,  Mette Dahl Andersen ,  Rune Salbo ,  Emily Waters ,  Lisbeth Moreau Andersen ,  Kristoffer Winther Balling

IPC: C07K16/36

CPC classification number: C07K16/36 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/522 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76

Abstract: The present invention relates to pro-coagulant human Protein S inhibitors, such as antibodies or antigen-binding fragments thereof that can be administered subcutaneously as prophylactic treatment for haemophilia patients regardless of inhibitor status and without interfering with non-coagulant functions of Protein S.

Abstract translation: 本发明涉及促凝血人蛋白S抑制剂，例如抗体或其抗原结合片段，其可以作为血友病患者的预防性治疗皮下施用，而不管抑制剂状态如何，并且不干扰蛋白S的非凝血功能。