公开(公告)号：US20210347831A1

公开(公告)日：2021-11-11

申请号：US17277468

申请日：2019-09-15

Applicant: NATIONAL UNIVERSITY CORPORATION, IWATE UNIVERSITY

Inventor： Hiroshi TOMITA ,  Eriko SUGANO ,  Kitako TABATA ,  Yoshito WATANABE

IPC: C07K14/405 ,  C12N15/86 ,  A61P27/02

Abstract: An object of the present invention is to provide a modified channel rhodopsin capable of opening and closing an ion channel by irradiation with light at different wavelengths, and/or having high ion permeability (photoreactivity). The solution is to substitute a C-terminal region of a channel rhodopsin obtained by substituting an N-terminal region of a Volvox carteri-derived channel rhodopsin by an N-terminal region of a Chlamydomonas reinhardtii-derived channel rhodopsin-1, by a C-terminal region of a Chlamydomonas reinhardtii-derived channel rhodopsin-2 or a C-terminal region of a Tetraselmis striata-derived channel rhodopsin.