公开(公告)号：US10400287B2

公开(公告)日：2019-09-03

申请号：US15433249

申请日：2017-02-15

申请人： Myriad Genetics, Inc.

发明人： Victor Abkevich ,  Kirsten Timms ,  Alexander Gutin ,  Julia Reid

IPC分类号： C12Q1/68 ,  C12Q1/6886

摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of homologous recombination deficiency (HRD) or an HRD signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an HRD signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.

公开(公告)号：US20190153542A1

公开(公告)日：2019-05-23

申请号：US16256908

申请日：2019-01-24

申请人： Myriad Genetics, Inc.

发明人： Steven Stone ,  Alexander Gutin ,  Susanne Wagner ,  Julia Reid

IPC分类号： C12Q1/6886 ,  G16B20/00

摘要： Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided.

公开(公告)号：US20150232947A1

公开(公告)日：2015-08-20

申请号：US14632622

申请日：2015-02-26

申请人： Myriad Genetics, Inc.

发明人： Steven Stone ,  Alexander Gutin ,  Susanne Wagner ,  Julia Reid

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G16B20/00 ,  G16B40/00

摘要： Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided.

摘要翻译： 提供了使用生物标志物预测患者癌症复发风险的生物标志物和方法。

公开(公告)号：US20240182979A1

公开(公告)日：2024-06-06

申请号：US18442036

申请日：2024-02-14

申请人： Myriad Genetics, Inc.

发明人： Steven Stone ,  Alexander Gutin ,  Susanne Wagner ,  Julia Reid

IPC分类号： C12Q1/6886 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B40/00 ,  G16B40/30

CPC分类号： C12Q1/6886 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B40/30 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G16B40/00

摘要： Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided.

公开(公告)号：US20170247768A1

公开(公告)日：2017-08-31

申请号：US15588458

申请日：2017-05-05

申请人： Myriad Genetics, Inc.

发明人： Steven Stone ,  Alexander Gutin ,  Susanne Wagner ,  Julia Reid

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G06F19/18 ,  G06F19/24

摘要： Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided.

公开(公告)号：US20170096712A1

公开(公告)日：2017-04-06

申请号：US15237401

申请日：2016-08-15

申请人： Myriad Genetics, Inc.

发明人： Steven Stone ,  Alexander Gutin ,  Susanne Wagner ,  Julia Reid

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  G16B25/00

摘要： Biomarkers and methods using the biomarkers for molecular detection and classification of disease and, particularly, molecular markers for cancer diagnosis and prognosis and methods of use thereof are provided.

公开(公告)号：US10519513B2

公开(公告)日：2019-12-31

申请号：US16256908

申请日：2019-01-24

申请人： Myriad Genetics, Inc.

发明人： Steven Stone ,  Alexander Gutin ,  Susanne Wagner ,  Julia Reid

IPC分类号： C12Q1/6886 ,  G16B20/00 ,  G16B40/00

摘要： Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided.

公开(公告)号：US09976188B2

公开(公告)日：2018-05-22

申请号：US15588458

申请日：2017-05-05

申请人： Myriad Genetics, Inc.

发明人： Steven Stone ,  Alexander Gutin ,  Susanne Wagner ,  Julia Reid

IPC分类号： G01N33/48 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G06F19/18 ,  G06F19/24

摘要： Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided.

公开(公告)号：US20170283879A1

公开(公告)日：2017-10-05

申请号：US15433249

申请日：2017-02-15

申请人： Myriad Genetics, Inc.

发明人： Victor Abkevich ,  Kirsten Timms ,  Alexander Gutin ,  Julia Reid

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156

摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of homologous recombination deficiency (HRD) or an HRD signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an HRD signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.

公开(公告)号：US20230117133A1

公开(公告)日：2023-04-20

申请号：US18081603

申请日：2022-12-14

申请人： Myriad Genetics, Inc.

发明人： Victor Abkevich ,  Kirsten Timms ,  Alexander Gutin ,  Julia Reid

IPC分类号： C12Q1/6886

摘要： This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of homologous recombination deficiency (HRD) or an HRD signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an HRD signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.