公开(公告)号：US20190002880A1

公开(公告)日：2019-01-03

申请号：US16131512

申请日：2018-09-14

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Tod Woolf ,  Kristin Wiederholt

IPC: C12N15/113 ,  C12N15/11 ,  A61K31/713 ,  C12N13/00

Abstract: Antisense sequences, including duplex RNAi compositions, which possess improved properties over those taught in the prior art are disclosed. The invention provides optimized antisense oligomer compositions and method for making and using the both in in vitro systems and therapeutically. The invention also provides methods of making and using the improved antisense oligomer compositions.

公开(公告)号：US09796978B1

公开(公告)日：2017-10-24

申请号：US15652219

申请日：2017-07-17

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Tod Woolf ,  Margaret Taylor

IPC: C07H21/02 ,  C07H21/04 ,  A61K31/70 ,  C12N15/113 ,  A61K31/713 ,  C12N15/11 ,  C12N5/00

CPC classification number: C12N15/1137 ,  A61K31/713 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2320/50 ,  C12N2330/30 ,  C12Y207/11022 ,  C12Y301/03048

Abstract: The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.

公开(公告)号：US10106793B2

公开(公告)日：2018-10-23

申请号：US15418653

申请日：2017-01-27

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Tod Woolf ,  Kristin Wiederholt

IPC: C12N15/113 ,  C12N13/00

Abstract: Antisense sequences, including duplex RNAi compositions, which possess improved properties over those taught in the prior art are disclosed. The invention provides optimized antisense oligomer compositions and method for making and using the both in in vitro systems and therapeutically. The invention also provides methods of making and using the improved antisense oligomer compositions.

公开(公告)号：US10036025B2

公开(公告)日：2018-07-31

申请号：US15724224

申请日：2017-10-03

Applicant: Life Technologies Corporation

Inventor： Tod Woolf ,  Margaret Taylor

IPC: C07H21/02 ,  C07H21/04 ,  A61K31/70 ,  C12N15/113 ,  A61K31/713 ,  C12N15/11 ,  C12N5/00

CPC classification number: C12N15/1137 ,  A61K31/713 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2320/50 ,  C12N2330/30 ,  C12Y207/11022 ,  C12Y301/03048

Abstract: The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.

公开(公告)号：US20190316138A1

公开(公告)日：2019-10-17

申请号：US16253180

申请日：2019-01-21

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Tod Woolf ,  Margaret Taylor

IPC: C12N15/113 ,  A61K31/713 ,  C12N15/11

Abstract: The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.

公开(公告)号：US09777275B2

公开(公告)日：2017-10-03

申请号：US13800845

申请日：2013-03-13

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Tod Woolf ,  Margaret Taylor

IPC: A61K31/70 ,  C07H21/02 ,  C12N15/113 ,  A61K31/713 ,  C12N15/11 ,  C12N5/00

CPC classification number: C12N15/1137 ,  A61K31/713 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2320/50 ,  C12N2330/30 ,  C12Y207/11022 ,  C12Y301/03048

Abstract: The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.

公开(公告)号：US09592250B2

公开(公告)日：2017-03-14

申请号：US14446022

申请日：2014-07-29

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Tod Woolf ,  Kristin Wiederholt

IPC: C12N15/11 ,  A61K31/713 ,  C12N15/113

CPC classification number: C12N15/113 ,  A61K31/713 ,  C12N13/00 ,  C12N15/111 ,  C12N15/1135 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/33 ,  C12N2310/351 ,  C12N2310/53 ,  C12N2320/31 ,  C12N2320/50 ,  C12N2320/51 ,  C12Y207/11022 ,  C12Y301/03048

Abstract: Antisense sequences, including duplex RNAi compositions, which possess improved properties over those taught in the prior art are disclosed. The invention provides optimized antisense oligomer compositions and method for making and using the both in in vitro systems and therapeutically. The invention also provides methods of making and using the improved antisense oligomer compositions.

Abstract translation: 公开了具有比现有技术中教导的那些改进的性能的反义序列，包括双链RNAi组合物。 本发明提供了在体外系统和治疗上制备和使用这两者的优化的反义寡聚体组合物和方法。 本发明还提供了制备和使用改进的反义寡聚体组合物的方法。

公开(公告)号：US10196640B1

公开(公告)日：2019-02-05

申请号：US16015009

申请日：2018-06-21

Applicant: Life Technologies Corporation

Inventor： Tod Woolf ,  Margaret Taylor

IPC: C07H21/02 ,  C07H21/04 ,  A61K31/70 ,  C12N15/113 ,  A61K31/713 ,  C12N15/11 ,  C12N5/00

Abstract: The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.

公开(公告)号：US20130303586A1

公开(公告)日：2013-11-14

申请号：US13800845

申请日：2013-03-13

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Tod Woolf ,  Margaret Taylor

IPC: A61K31/713

CPC classification number: C12N15/1137 ,  A61K31/713 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2320/50 ,  C12N2330/30 ,  C12Y207/11022 ,  C12Y301/03048

Abstract: The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.